PMID- 37474658
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231130
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 33
IP  - 12
DP  - 2023 Dec
TI  - Assessment of lacrimal gland involvement in primary Sjogren's syndrome using 
      gray-scale ultrasonography and shear wave elastography.
PG  - 9368-9377
LID - 10.1007/s00330-023-09943-z [doi]
AB  - OBJECTIVES: The aim of this study was to assess lacrimal gland involvement in 
      primary Sjogren's syndrome (pSS) using lacrimal gland gray-scale ultrasound 
      (LGUS) and two-dimensional shear wave elastography (2D-SWE). METHODS: Eighty-five 
      pSS patients with a mean age of 51.16 +/- 10.61 years and 84 sex- and age-matched 
      healthy subjects with a mean age of 50.94 +/- 11.05 years were included in the 
      study. Lacrimal gland parenchymal findings and 2D-SWE values were compared 
      between the two groups and the correlations of LGUS parameters with clinical 
      findings, dry eye tests, and minor salivary gland biopsy (MSGB) were further 
      investigated. RESULTS: LGUS parenchymal grade was 0 in 14 (16.5%), 1 in 45 
      (52.9%), 2 in 23 (27.1%), and 3 in 3 patients (3.5%) in the pSS group, while in 
      the control group, parenchymal grades were 0 (57.1%) and 1 (42.9%). The mean 
      2D-SWE value of pSS patients was significantly higher than the control group 
      (p < 0.05) and increased parallel with lacrimal parenchymal grade. The elasticity 
      modulus had a high diagnostic performance in detecting lacrimal gland involvement 
      in pSS patients (AUC 0.901, sensitivity 70.6%, specificity 97.6%), while the 
      diagnostic performance of LGUS was much lower (AUC 0.769, sensitivity 83.5%, 
      specificity 57.1%). LGUS and 2D-SWE values were found to be correlated with dry 
      eye tests and MSGB results (p < 0.05). CONCLUSIONS: LGUS and 2D-SWE are both 
      useful for assessing the lacrimal gland involvement in pSS patients; however, 
      2D-SWE has a better diagnostic performance than LGUS and found to be correlated 
      with dry eye tests. CLINICAL RELEVANCE STATEMENT: Lacrimal gland US and 
      two-dimensional shear wave elastography (2D-SWE) are imaging modalities that can 
      be used to demonstrate parenchymal involvement of the lacrimal gland in primary 
      Sjogren's syndrome (pSS). KEY POINTS: * Gray-scale US and two-dimensional shear 
      wave elastography (2D-SWE) have been widely used in the recent decade to assess 
      gland involvement in patients with primary Sjogren's syndrome (pSS). * The 
      elasticity modulus had a high diagnostic performance in detecting lacrimal gland 
      involvement in primary Sjogren's syndrome (pSS) patients. * Lacrimal gland US and 
      two-dimensional shear wave elastography (2D-SWE) are both useful for assessing 
      the lacrimal gland in primary Sjogren's syndrome (pSS) patients; however, 
      two-dimensional shear wave elastography (2D-SWE) has a better diagnostic 
      performance than lacrimal gland ultrasound (LGUS).
CI  - (c) 2023. The Author(s), under exclusive licence to European Society of Radiology.
FAU - Ozer, Halil
AU  - Ozer H
AUID- ORCID: 0000-0003-1141-1094
AD  - Department of Radiology, Faculty of Medicine, Selcuk University, Konya, 42131, 
      Turkey. drhalilozer@gmail.com.
FAU - Yilmaz, Sema
AU  - Yilmaz S
AD  - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, 
      Selcuk University, Konya, Turkey.
FAU - Bozkurt, Banu
AU  - Bozkurt B
AD  - Department of Ophthalmology, Faculty of Medicine, Selcuk University, Konya, 
      Turkey.
FAU - Tezcan, Dilek
AU  - Tezcan D
AD  - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, 
      Selcuk University, Konya, Turkey.
FAU - Yazol, Merve
AU  - Yazol M
AD  - Department of Radiology, Faculty of Medicine, Gazi University, Ankara, Turkey.
FAU - Hakbilen, Selda
AU  - Hakbilen S
AD  - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, 
      Selcuk University, Konya, Turkey.
FAU - Topaloglu, Omer Faruk
AU  - Topaloglu OF
AD  - Department of Radiology, Faculty of Medicine, Selcuk University, Konya, 42131, 
      Turkey.
FAU - Durmaz, Mehmet Sedat
AU  - Durmaz MS
AD  - Department of Radiology, Faculty of Medicine, Selcuk University, Konya, 42131, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20230720
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
RN  - 89022-11-7 (2'-carbomethoxyphenyl 4-guanidinobenzoate)
SB  - IM
MH  - Humans
MH  - Adult
MH  - Middle Aged
MH  - *Elasticity Imaging Techniques/methods
MH  - *Sjogren's Syndrome/diagnostic imaging/pathology
MH  - *Lacrimal Apparatus/diagnostic imaging
MH  - Ultrasonography/methods
OTO - NOTNLM
OT  - Lacrimal gland
OT  - Sjogren's syndrome
OT  - Sonoelastography
OT  - Ultrasonography
EDAT- 2023/07/21 01:12
MHDA- 2023/11/27 12:44
CRDT- 2023/07/20 23:27
PHST- 2023/01/04 00:00 [received]
PHST- 2023/05/16 00:00 [accepted]
PHST- 2023/04/30 00:00 [revised]
PHST- 2023/11/27 12:44 [medline]
PHST- 2023/07/21 01:12 [pubmed]
PHST- 2023/07/20 23:27 [entrez]
AID - 10.1007/s00330-023-09943-z [pii]
AID - 10.1007/s00330-023-09943-z [doi]
PST - ppublish
SO  - Eur Radiol. 2023 Dec;33(12):9368-9377. doi: 10.1007/s00330-023-09943-z. Epub 2023 
      Jul 20.