PMID- 37475577
OWN - NLM
STAT- MEDLINE
DCOM- 20240311
LR  - 20240311
IS  - 1939-0041 (Electronic)
IS  - 1939-0041 (Linking)
VI  - 16
IP  - 1
DP  - 2024 Jan-Feb
TI  - Ultrasound-mediated nano-sized drug delivery systems for cancer treatment: 
      Multi-scale and multi-physics computational modeling.
PG  - e1913
LID - 10.1002/wnan.1913 [doi]
AB  - Computational modeling enables researchers to study and understand various 
      complex biological phenomena in anticancer drug delivery systems (DDSs), 
      especially nano-sized DDSs (NSDDSs). The combination of NSDDSs and therapeutic 
      ultrasound (TUS), that is, focused ultrasound and low-intensity pulsed 
      ultrasound, has made significant progress in recent years, opening many 
      opportunities for cancer treatment. Multiple parameters require tuning and 
      optimization to develop effective DDSs, such as NSDDSs, in which mathematical 
      modeling can prove advantageous. In silico computational modeling of 
      ultrasound-responsive DDS typically involves a complex framework of acoustic 
      interactions, heat transfer, drug release from nanoparticles, fluid flow, mass 
      transport, and pharmacodynamic governing equations. Owing to the rapid 
      development of computational tools, modeling the different phenomena in 
      multi-scale complex problems involved in drug delivery to tumors has become 
      possible. In the present study, we present an in-depth review of recent advances 
      in the mathematical modeling of TUS-mediated DDSs for cancer treatment. A 
      detailed discussion is also provided on applying these computational models to 
      improve the clinical translation for applications in cancer treatment. This 
      article is categorized under: Nanotechnology Approaches to Biology > Nanoscale 
      Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for 
      Oncologic Disease.
CI  - (c) 2023 The Authors. WIREs Nanomedicine and Nanobiotechnology published by Wiley 
      Periodicals LLC.
FAU - Moradi Kashkooli, Farshad
AU  - Moradi Kashkooli F
AUID- ORCID: 0000-0003-4338-8538
AD  - Department of Physics, Toronto Metropolitan University, Toronto, Ontario, Canada.
FAU - Hornsby, Tyler K
AU  - Hornsby TK
AUID- ORCID: 0000-0001-5702-0596
AD  - Department of Physics, Toronto Metropolitan University, Toronto, Ontario, Canada.
FAU - Kolios, Michael C
AU  - Kolios MC
AUID- ORCID: 0000-0002-9994-8293
AD  - Department of Physics, Toronto Metropolitan University, Toronto, Ontario, Canada.
AD  - Institute for Biomedical Engineering, Science and Technology (iBEST), Keenan 
      Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, 
      Canada.
FAU - Tavakkoli, Jahangir Jahan
AU  - Tavakkoli JJ
AUID- ORCID: 0000-0003-1947-4479
AD  - Department of Physics, Toronto Metropolitan University, Toronto, Ontario, Canada.
AD  - Institute for Biomedical Engineering, Science and Technology (iBEST), Keenan 
      Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, 
      Canada.
LA  - eng
GR  - ALLRP 556270-20/Natural Sciences and Engineering Research Council of Canada 
      (NSERC) Alliance grants/
GR  - RGPIN-2022-03799/Natural Sciences and Engineering Research Council of Canada 
      (NSERC) Alliance grants/
GR  - RGPIN-2022-04143/Natural Sciences and Engineering Research Council of Canada 
      (NSERC) Alliance grants/
GR  - Ontario Research Fund-Research Excellence (ORF-RE #RE02-032)/
GR  - NSERC Banting Postdoctoral Fellowship/
GR  - Toronto Poly Clinic Inc/
PT  - Journal Article
PT  - Review
DEP - 20230720
PL  - United States
TA  - Wiley Interdiscip Rev Nanomed Nanobiotechnol
JT  - Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
JID - 101508311
RN  - 0 (Nanoparticle Drug Delivery System)
SB  - IM
MH  - Humans
MH  - Nanoparticle Drug Delivery System
MH  - Drug Delivery Systems
MH  - *Neoplasms/diagnostic imaging/drug therapy
MH  - Computer Simulation
MH  - *Nanoparticles
MH  - Physics
OTO - NOTNLM
OT  - mathematical model of drug release kinetics from nanoparticles
OT  - multi-physics and multi-scale computational modeling
OT  - nano-sized drug delivery systems
OT  - solid tumor
OT  - therapeutic ultrasound
OT  - ultrasound-mediated drug delivery
EDAT- 2023/07/21 06:43
MHDA- 2024/03/11 06:43
CRDT- 2023/07/21 02:53
PHST- 2023/05/18 00:00 [revised]
PHST- 2022/12/12 00:00 [received]
PHST- 2023/05/30 00:00 [accepted]
PHST- 2024/03/11 06:43 [medline]
PHST- 2023/07/21 06:43 [pubmed]
PHST- 2023/07/21 02:53 [entrez]
AID - 10.1002/wnan.1913 [doi]
PST - ppublish
SO  - Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024 Jan-Feb;16(1):e1913. doi: 
      10.1002/wnan.1913. Epub 2023 Jul 20.