PMID- 37475732
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231102
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 14
DP  - 2023
TI  - Micro- and macro-changes in early-stage type 2 diabetes mellitus without 
      cognitive impairment: a diffusion tensor imaging (DTI) and surface-based 
      morphometry (SBM) study.
PG  - 1115634
LID - 10.3389/fneur.2023.1115634 [doi]
LID - 1115634
AB  - INTRODUCTION: Brain structure and function changes are considered major brain 
      damages in type 2 diabetes mellitus (T2DM), which likely has a close relationship 
      with cognitive impairment. Many previous studies have shown by using brain 
      structural and functional magnetic resonance imaging (MRI) methods that brain 
      white and gray matter are damaged in T2DM, leading to cognitive impairment. 
      Researches neglected patients of T2DM without cognitive dysfunction might also 
      have brain changes. METHODS: In this study, subjects with early stage T2DM with 
      no cognitive dysfunction were enrolled to detect brain damages using the 
      tract-based spatial statistics analysis (TBSS) method to demonstrate white matter 
      (WM) micro changes and surface-based morphometry (SBM) method to assess cerebral 
      cortex macro changes. RESULTS: The whole-brain TBSS analysis revealed that there 
      were no statistically significant changes in fractional anisotropy (FA) and mean 
      diffusivity (MD), but the FA declined in some area of cerebral WM (p < 0.1). The 
      SBM results showed no changes in cortical thickness (CT), cortical volume (CV), 
      surface area (SA), and cortical sulcal curve (CSC) between these two groups, but 
      pial local gyration index (LGI) was decreased in the precuneus (-log10, p = 
      -3.327). DISCUSSION: In conclusion, early stage T2DM patients without cognitive 
      impairment had brain micro and macro structural damages, suggesting the potential 
      use of MRI as an imaging marker to detect brain changes in early stage T2DM, 
      which could not be observed and assessed clinically.
CI  - Copyright (c) 2023 Tang, Chen, Tan, Fang, Yu, Chen, Li, Hu, Ding and Zhang.
FAU - Tang, Xiangyong
AU  - Tang X
AD  - Department of Medical Imaging, Affiliated Longhua People's Hospital, Southern 
      Medical University, Shenzhen, China.
FAU - Chen, Yanzi
AU  - Chen Y
AD  - Department of Medical Imaging, Affiliated Longhua People's Hospital, Southern 
      Medical University, Shenzhen, China.
FAU - Tan, Hui
AU  - Tan H
AD  - Department of Medical Imaging, Second Affiliated Hospital, Shantou University 
      Medical College, Shantou, China.
FAU - Fang, Jinzhi
AU  - Fang J
AD  - Department of Medical Imaging, Affiliated Longhua People's Hospital, Southern 
      Medical University, Shenzhen, China.
FAU - Yu, Dafei
AU  - Yu D
AD  - Department of Medical Imaging, Affiliated Longhua People's Hospital, Southern 
      Medical University, Shenzhen, China.
FAU - Chen, Cuimei
AU  - Chen C
AD  - Department of Medical Imaging, Affiliated Longhua People's Hospital, Southern 
      Medical University, Shenzhen, China.
FAU - Li, Xiao
AU  - Li X
AD  - Department of Medical Imaging, Affiliated Longhua People's Hospital, Southern 
      Medical University, Shenzhen, China.
FAU - Hu, Ziqi
AU  - Hu Z
AD  - Department of Medical Imaging, Affiliated Longhua People's Hospital, Southern 
      Medical University, Shenzhen, China.
FAU - Ding, Ling
AU  - Ding L
AD  - Department of Medical Imaging, Affiliated Longhua People's Hospital, Southern 
      Medical University, Shenzhen, China.
FAU - Zhang, Yuzhong
AU  - Zhang Y
AD  - Department of Medical Imaging, Affiliated Longhua People's Hospital, Southern 
      Medical University, Shenzhen, China.
LA  - eng
PT  - Journal Article
DEP - 20230705
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC10354865
OTO - NOTNLM
OT  - FreeSurfer
OT  - cortex
OT  - diffusion tenser imaging
OT  - type 2 diabetes mellitus
OT  - white matter
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/07/21 06:44
MHDA- 2023/07/21 06:45
PMCR- 2023/07/05
CRDT- 2023/07/21 03:54
PHST- 2022/12/04 00:00 [received]
PHST- 2023/05/26 00:00 [accepted]
PHST- 2023/07/21 06:45 [medline]
PHST- 2023/07/21 06:44 [pubmed]
PHST- 2023/07/21 03:54 [entrez]
PHST- 2023/07/05 00:00 [pmc-release]
AID - 10.3389/fneur.2023.1115634 [doi]
PST - epublish
SO  - Front Neurol. 2023 Jul 5;14:1115634. doi: 10.3389/fneur.2023.1115634. eCollection 
      2023.