PMID- 37480201
OWN - NLM
STAT- MEDLINE
DCOM- 20230724
LR  - 20230726
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 44
IP  - 4
DP  - 2023 Jul 1
TI  - Total serum immunoglobulin E (IgE) as an effective predictor for identifying 
      allergic asthma in childhood asthma.
PG  - 252-257
LID - 10.2500/aap.2023.44.230014 [doi]
AB  - Background: Allergic asthma accounts for the majority of childhood asthma and is 
      characterized by elevated total serum immunoglobulin E (tIgE). However, whether 
      tIgE can predict allergic asthma in childhood asthma remains unclear. Objective: 
      The purpose of this study was to identify the potential of tIgE for predicting 
      allergic asthma in childhood asthma and provide a reliable reference value. 
      Methods: Clinical characteristics and the level of tIgE from children with asthma 
      in 2008 (n = 280) and 2018 (n = 479) were retrospectively analyzed. Receiver 
      operating characteristic (ROC) curves were generated to determine the optimal 
      cutoff points and predictive values of tIgE for diagnosing allergic asthma in 
      childhood asthma in 2008 and 2018, and the diagnosis efficiency of tIgE was 
      validated in 491 children with asthma of 2019. Results: The level of tIgE was 
      significantly lower in 2018 than that in 2008. Receiver operating characteristic 
      curves showed cutoff values of tIgE were 142.50 IU/mL (area under the curve [AUC] 
      = 0.864) and 96.25 IU/mL (AUC = 0.835) for diagnosing allergic asthma in 2008 and 
      2018, respectively. The level of tIgE from children with asthma in 2019 was 
      similar to that in 2018 but was significantly lower than that in 2008. We further 
      used the cutoff value of tIgE = 96.25 IU/mL to validate the diagnosis efficiency 
      in children with asthma of 2019 and found that the diagnostic accuracy, 
      sensitivity, specificity of allergic asthma, and the Youden index reached 76.78%, 
      76.10%, 78.03%, and 0.540, respectively. Conclusion: The tIgE value is an 
      effective predictor for diagnosing allergic asthma in childhood asthma, with tIgE 
      = 96.25 IU/mL being the recommended limit.
FAU - Wang, Jianwei
AU  - Wang J
AD  - From the Department of Otolaryngology, Head and Neck Surgery. Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China, and.
FAU - Yang, Yujuan
AU  - Yang Y
AD  - From the Department of Otolaryngology, Head and Neck Surgery. Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China, and.
FAU - Cao, Jiayu
AU  - Cao J
AD  - From the Department of Otolaryngology, Head and Neck Surgery. Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China, and.
FAU - Song, Xiaoyu
AU  - Song X
AD  - From the Department of Otolaryngology, Head and Neck Surgery. Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China, and.
FAU - Guo, Jing
AU  - Guo J
AD  - From the Department of Otolaryngology, Head and Neck Surgery. Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China, and.
FAU - Yu, Pengyi
AU  - Yu P
AD  - From the Department of Otolaryngology, Head and Neck Surgery. Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China, and.
FAU - Liu, Zhen
AU  - Liu Z
AD  - From the Department of Otolaryngology, Head and Neck Surgery. Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China, and.
FAU - Zhang, Wenbin
AU  - Zhang W
AD  - From the Department of Otolaryngology, Head and Neck Surgery. Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China, and.
FAU - Liu, Xinyue
AU  - Liu X
AD  - From the Department of Otolaryngology, Head and Neck Surgery. Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China, and.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - From the Department of Otolaryngology, Head and Neck Surgery. Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China, and.
FAU - Song, Xicheng
AU  - Song X
AD  - From the Department of Otolaryngology, Head and Neck Surgery. Yantai Yuhuangding 
      Hospital, Qingdao University, Yantai, China, and.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Child
MH  - Humans
MH  - Retrospective Studies
MH  - *Asthma/diagnosis
MH  - Immunoglobulin E
MH  - ROC Curve
MH  - Reference Values
EDAT- 2023/07/22 11:42
MHDA- 2023/07/24 06:42
CRDT- 2023/07/22 00:43
PHST- 2023/07/24 06:42 [medline]
PHST- 2023/07/22 11:42 [pubmed]
PHST- 2023/07/22 00:43 [entrez]
AID - 10.2500/aap.2023.44.230014 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2023 Jul 1;44(4):252-257. doi: 10.2500/aap.2023.44.230014.