PMID- 37481885
OWN - NLM
STAT- MEDLINE
DCOM- 20230920
LR  - 20230920
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 266
IP  - Pt 1
DP  - 2024 Jan 1
TI  - Electrochemiluminescence enhanced by isolating ACQphores in imine-linked covalent 
      organic framework for organophosphorus pesticide assay.
PG  - 124964
LID - S0039-9140(23)00715-4 [pii]
LID - 10.1016/j.talanta.2023.124964 [doi]
AB  - Most of covalent organic frameworks (COFs) are non or weakly emissive due to 
      either the molecular thermal motion-mediated energy dissipation or the 
      aggregation-caused quenching (ACQ) effect. Herein, we synthesize an imine-linked 
      COF (TFPPy-TPh-COF) with high electrochemiluminescence (ECL) emission and the 
      capability of eliminating the ACQ effect and further construct an ECL sensor for 
      malathion detection. The imine-linked COF is obtained by the condensation 
      reaction of (1,1':3',1''-terphenyl)-4,4''-diamine (TPh) and 
      1,3,6,8-tetrakis(p-formylphenyl)pyrene (TFPPy), and it has higher ECL efficiency 
      than TFPPy aggregates due to the separation of ACQ luminophores (i.e., TFPPy) 
      from each other by TPh and the restriction of intramolecular motions of TFPPy and 
      TPh to reduce the nonradiative decay. The efficient quenching of ECL is achieved 
      by electrochemiluminescence resonance energy transfer (ERET) from the excited 
      state of the TFPPy-TPh-COF to zeolite imidazolate framework-8 (ZIF-8) and the 
      steric hindrance of ZIF-8. Acetylcholinesterase (AChE) can enzymatically 
      hydrolyze acetylcholine (ACh) to generate acetic acid. The resultant acetic acid 
      can trigger the dissolution of ZIF-8 to produce an enhanced ECL signal. Malathion 
      as an organophosphorus pesticide serves as an AChE inhibitor to prevent the 
      production of acetic acid, inducing the decrease of ECL signal. This sensor 
      displays a limit of detection (LOD) of 2.44 pg/mL and a wide dynamic detection 
      range of 0.01-1000 ng/mL. Furthermore, it can be used to detect other 
      organophosphates pesticides (e.g., methidathion, chlorpyrifos, and paraoxon) and 
      measure malathion in real samples (i.e., pakchoi, lettuce, and apples).
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Song, Linlin
AU  - Song L
AD  - College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal 
      University, Jinan, 250014, China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal 
      University, Jinan, 250014, China.
FAU - Min, Lei
AU  - Min L
AD  - College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal 
      University, Jinan, 250014, China.
FAU - Guo, Xinyu
AU  - Guo X
AD  - College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal 
      University, Jinan, 250014, China.
FAU - Gao, Wenqiang
AU  - Gao W
AD  - Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic 
      Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, 
      China. Electronic address: gaowenqiang@iccas.ac.cn.
FAU - Cui, Lin
AU  - Cui L
AD  - College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal 
      University, Jinan, 250014, China. Electronic address: zpbzcl@126.com.
FAU - Zhang, Chun-Yang
AU  - Zhang CY
AD  - School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 
      211189, China. Electronic address: cyzhang@sdnu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230719
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Metal-Organic Frameworks)
RN  - 0 (Pesticides)
RN  - 0 (Organophosphorus Compounds)
RN  - U5N7SU872W (Malathion)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
SB  - IM
MH  - *Metal-Organic Frameworks/chemistry
MH  - *Pesticides/analysis
MH  - Organophosphorus Compounds
MH  - Malathion
MH  - Acetylcholinesterase
MH  - Luminescent Measurements
MH  - *Biosensing Techniques
MH  - Electrochemical Techniques
OTO - NOTNLM
OT  - Aggregation-caused quenching
OT  - Covalent organic frameworks
OT  - ECL biosensor
OT  - Organophosphorus pesticides
OT  - Zeolite imidazolate framework-8
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/07/24 00:41
MHDA- 2023/09/20 06:42
CRDT- 2023/07/23 18:04
PHST- 2023/05/09 00:00 [received]
PHST- 2023/07/04 00:00 [revised]
PHST- 2023/07/18 00:00 [accepted]
PHST- 2023/09/20 06:42 [medline]
PHST- 2023/07/24 00:41 [pubmed]
PHST- 2023/07/23 18:04 [entrez]
AID - S0039-9140(23)00715-4 [pii]
AID - 10.1016/j.talanta.2023.124964 [doi]
PST - ppublish
SO  - Talanta. 2024 Jan 1;266(Pt 1):124964. doi: 10.1016/j.talanta.2023.124964. Epub 
      2023 Jul 19.