PMID- 37482592
OWN - NLM
STAT- MEDLINE
DCOM- 20230825
LR  - 20240327
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 40
DP  - 2023 Aug
TI  - Biomarkers of organophosphate insecticides exposure and asthma in general US 
      adults: findings from NHANES 1999-2018 data.
PG  - 92295-92305
LID - 10.1007/s11356-023-28740-1 [doi]
AB  - The limited evidence linking exposure to organophosphate insecticides (OPIs) and 
      asthma in the general population prompted us to investigate this association. Our 
      study focused on US adults and utilized representative samples from the National 
      Health and Nutrition Examination Survey (NHANES). From the 7 NHANES waves 
      (1999-2018), we detected OPIs exposure using the urinary concentrations of six 
      metabolites of dialkyl phosphates (DAPs). To evaluate the relationship between 
      these OPIs and asthma, we employed three statistical methods: 
      survey-multivariable logistic regression (SMLR), generalized weighted quantile 
      sum (WQS) regression, and Bayesian kernel machine regression (BKMR). Stratified 
      analyses were done based on the relevant variable subgroups, and sensitivity 
      analyses were carried out to evaluate the robustness of findings. A total of 6009 
      adults aged from 20 to 85 years old, representing the 313.5 million adults in the 
      non-institutionalized US population, were included in our analyses. Among them, 
      842 participants were determined as asthma patients with an age-adjusted 
      prevalence of 14.2%. Our results showed that dimethyl phosphate (DMP) (adjusted 
      odd ratio (AOR) = 1.471, 95% CI: 1.086, 1.993), diethyl phosphate (DEP) (AOR = 
      1.453, 95% CI: 1.118, 1.888), dimethyl thiophosphate (DMTP) (AOR = 1.454, 95% CI: 
      1.071, 1.973), and dimethyl dithiophosphate (DMDTP) (AOR = 1.478, 95% CI: 1.119, 
      1.953) had a positive correlation with asthma in adults. This association was 
      stronger in females, non-Hispanic White populations and those with a small amount 
      of physical activity. Our study findings indicated that exposure to OPIs may 
      elevate the risk of asthma in US general adults. Specifically, females, 
      individuals from non-Hispanic White backgrounds, and those with lower levels of 
      physical activity are more susceptible to developing asthma when exposed to OPIs.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Liang, Jing-Hong
AU  - Liang JH
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China.
FAU - Liu, Mei-Ling
AU  - Liu ML
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China.
FAU - Pu, Ying-Qi
AU  - Pu YQ
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China.
FAU - Huang, Shan
AU  - Huang S
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China.
FAU - Jiang, Nan
AU  - Jiang N
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China.
FAU - Huang, Shao-Yi
AU  - Huang SY
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China.
FAU - Pu, Xue-Ya
AU  - Pu XY
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China.
FAU - Dong, Guang-Hui
AU  - Dong GH
AD  - Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, 
      Guangdong Provincial Engineering Technology Research Center of Environmental and 
      Health risk Assessment, Department of Occupational and Environmental Health, 
      School of Public Health, SunYat-sen University, Guangzhou, 510080, People's 
      Republic of China.
FAU - Chen, Ya-Jun
AU  - Chen YJ
AUID- ORCID: 0000-0003-3132-2945
AD  - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen 
      University, No.74 Zhongshan 2nd Road, Yuexiu District, Guangzhou, People's 
      Republic of China. chenyj68@mail.sysu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230724
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Insecticides)
RN  - 0 (Organophosphates)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Female
MH  - Humans
MH  - Adult
MH  - Young Adult
MH  - Middle Aged
MH  - Aged
MH  - Aged, 80 and over
MH  - *Insecticides
MH  - Nutrition Surveys
MH  - Bayes Theorem
MH  - Organophosphates
MH  - Biomarkers/urine
MH  - Environmental Exposure
OTO - NOTNLM
OT  - Asthma
OT  - Environmental exposure
OT  - General adults
OT  - NHANES
OT  - Organophosphate insecticides
EDAT- 2023/07/24 00:41
MHDA- 2023/08/25 06:42
CRDT- 2023/07/23 23:07
PHST- 2023/04/28 00:00 [received]
PHST- 2023/07/07 00:00 [accepted]
PHST- 2023/08/25 06:42 [medline]
PHST- 2023/07/24 00:41 [pubmed]
PHST- 2023/07/23 23:07 [entrez]
AID - 10.1007/s11356-023-28740-1 [pii]
AID - 10.1007/s11356-023-28740-1 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Aug;30(40):92295-92305. doi: 
      10.1007/s11356-023-28740-1. Epub 2023 Jul 24.