PMID- 37482739
OWN - NLM
STAT- MEDLINE
DCOM- 20230725
LR  - 20230725
IS  - 0253-9624 (Print)
IS  - 0253-9624 (Linking)
VI  - 57
IP  - 7
DP  - 2023 Jul 6
TI  - [Application of mixture analysis methods in association between metals mixture 
      exposure and DNA oxidative damage].
PG  - 1026-1031
LID - 10.3760/cma.j.cn112150-20221031-01046 [doi]
AB  - Objectives: To study the association between metals mixture exposure and DNA 
      oxidative damage using mixture analysis methods, and to explore the most 
      significant exposure factors that cause DNA oxidative damage. Methods: Workers 
      from steel enterprises were recruited in Shandong Province. Urinary metals were 
      measured by using the inductively coupled plasma mass spectrometry method. The 
      level of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was determined by using the 
      ultra-high performance liquid chromatography-mass spectrometry method. Bayesian 
      kernel machine regression (BKMR), elastic net regression and quantile 
      g-computation regression were used to analyze the association between urinary 
      metals and urinary 8-OHdG. Results: A total of 768 subjects aged (36.15+/-7.40) 
      years old were included in the study. BKMR, elastic net regression and quantile 
      g-computation all revealed an overall positive association between the mixture 
      concentration and increased urinary 8-OHdG. The quantile g-computation results 
      showed that with a 25% increase in metal mixtures, the urinary 8-OHdG level 
      increased by 77.60%. The elastic net regression showed that with a 25% increase 
      in exposure risk score, the urinary 8-OHdG level increased by 26%. The BKMR 
      summarized the contribution of individual exposures to the response, and 
      selenium, zinc, and nickel were significant contributors to the urinary 8-OHdG 
      elevation. Conclusion: Exposure to mixed metals causes elevated levels of DNA 
      oxidative damage, and selenium, zinc, and nickel are significant exposure 
      factors.
FAU - Wang, Y H
AU  - Wang YH
AD  - National Institute for Occupational Health and Poison Control, Chinese Center for 
      Disease Control and Prevention, Beijing 100050, China.
FAU - Yuan, H G
AU  - Yuan HG
AD  - National Institute for Occupational Health and Poison Control, Chinese Center for 
      Disease Control and Prevention, Beijing 100050, China.
FAU - Zhang, L Y
AU  - Zhang LY
AD  - National Institute for Occupational Health and Poison Control, Chinese Center for 
      Disease Control and Prevention, Beijing 100050, China.
FAU - Lin, Y
AU  - Lin Y
AD  - National Institute for Occupational Health and Poison Control, Chinese Center for 
      Disease Control and Prevention, Beijing 100050, China.
FAU - Wang, T
AU  - Wang T
AD  - National Institute for Occupational Health and Poison Control, Chinese Center for 
      Disease Control and Prevention, Beijing 100050, China.
FAU - Xu, H
AU  - Xu H
AD  - West China School of Public Health and West China Fourth Hospital, Sichuan 
      University, Chengdu 610041, China.
FAU - Zhao, X
AU  - Zhao X
AD  - West China School of Public Health and West China Fourth Hospital, Sichuan 
      University, Chengdu 610041, China.
FAU - Duan, H W
AU  - Duan HW
AD  - National Institute for Occupational Health and Poison Control, Chinese Center for 
      Disease Control and Prevention, Beijing 100050, China.
LA  - chi
GR  - 2022YFC2503203/National Key R&D Program of China/
GR  - 82073525, 82103888/National Natural Science Foundation of China/
GR  - 7214279/Beijing Natural Science Foundation/
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yu Fang Yi Xue Za Zhi
JT  - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
JID - 7904962
RN  - 7OV03QG267 (Nickel)
RN  - H6241UJ22B (Selenium)
RN  - 0 (Metals)
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Humans
MH  - Adult
MH  - *Nickel/toxicity
MH  - *Selenium
MH  - Bayes Theorem
MH  - Metals/toxicity
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Oxidative Stress/physiology
MH  - Zinc
MH  - DNA Damage
EDAT- 2023/07/24 06:42
MHDA- 2023/07/25 06:43
CRDT- 2023/07/24 02:17
PHST- 2023/07/25 06:43 [medline]
PHST- 2023/07/24 06:42 [pubmed]
PHST- 2023/07/24 02:17 [entrez]
AID - 10.3760/cma.j.cn112150-20221031-01046 [doi]
PST - ppublish
SO  - Zhonghua Yu Fang Yi Xue Za Zhi. 2023 Jul 6;57(7):1026-1031. doi: 
      10.3760/cma.j.cn112150-20221031-01046.