PMID- 37482992
OWN - NLM
STAT- MEDLINE
DCOM- 20230905
LR  - 20231018
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Print)
IS  - 1387-2877 (Linking)
VI  - 95
IP  - 1
DP  - 2023
TI  - Impact of Yoga Versus Memory Enhancement Training on Hippocampal Connectivity in 
      Older Women at Risk for Alzheimer's Disease.
PG  - 149-159
LID - 10.3233/JAD-221159 [doi]
AB  - BACKGROUND: Yoga may be an ideal early intervention for those with modifiable 
      risk factors for Alzheimer's disease (AD) development. OBJECTIVE: To examine the 
      effects of Kundalini yoga (KY) training versus memory enhancement training (MET) 
      on the resting-state connectivity of hippocampal subregions in women with 
      subjective memory decline and cardiovascular risk factors for AD. METHODS: 
      Participants comprised women with subjective memory decline and cardiovascular 
      risk factors who participated in a parent randomized controlled trial 
      (NCT03503669) of 12-weeks of KY versus MET and completed pre- and 
      post-intervention resting-state magnetic resonance imaging scans (yoga: n = 11, 
      age = 61.45+/-6.58 years; MET: n = 11, age = 64.55+/-6.41 years). Group differences 
      in parcellated (Cole-anticevic atlas) hippocampal connectivity changes (post- 
      minus pre-intervention) were evaluated by partial least squares analysis, 
      controlling for age. Correlations between hippocampal connectivity and perceived 
      stress and frequency of forgetting (assessed by questionnaires) were also 
      evaluated. RESULTS: A left anterior hippocampal subregion assigned to the default 
      mode network (DMN) in the Cole-anticevic atlas showed greater increases in 
      connectivity with largely ventral visual stream regions with KY than with MET 
      (p < 0.001), which showed associations with lower stress (p < 0.05). Several 
      posterior hippocampal subregions assigned to sensory-based networks in the 
      Cole-anticevic atlas showed greater increases in connectivity with regions 
      largely in the DMN and frontoparietal network with MET than with KY (p < 0.001), 
      which showed associations with lower frequency of forgetting (p < 0.05). 
      CONCLUSION: KY training may better target stress-related hippocampal 
      connectivity, whereas MET may better target hippocampal sensory-integration 
      supporting better memory reliability, in women with subjective memory decline and 
      cardiovascular risk factors.
FAU - Kilpatrick, Lisa A
AU  - Kilpatrick LA
AD  - Department of Psychiatry, Jane and Terry Semel Institute for Neuroscience and 
      Human Behavior, University of California, Los Angeles, CA, USA.
AD  - G. Oppenheimer Center for Neurobiology of Stress and Resilience, University of 
      California, Los Angeles, CA, USA.
AD  - Goodman-Luskin Microbiome Center, University of California, Los Angeles, CA, USA.
FAU - Siddarth, Prabha
AU  - Siddarth P
AD  - Department of Psychiatry, Jane and Terry Semel Institute for Neuroscience and 
      Human Behavior, University of California, Los Angeles, CA, USA.
FAU - Krause-Sorio, Beatrix
AU  - Krause-Sorio B
AD  - Department of Psychiatry, Jane and Terry Semel Institute for Neuroscience and 
      Human Behavior, University of California, Los Angeles, CA, USA.
FAU - Milillo, Michaela M
AU  - Milillo MM
AD  - Department of Psychiatry, Jane and Terry Semel Institute for Neuroscience and 
      Human Behavior, University of California, Los Angeles, CA, USA.
FAU - Aguilar-Faustino, Yesenia
AU  - Aguilar-Faustino Y
AD  - Department of Psychiatry, Jane and Terry Semel Institute for Neuroscience and 
      Human Behavior, University of California, Los Angeles, CA, USA.
FAU - Ercoli, Linda
AU  - Ercoli L
AD  - Department of Psychiatry, Jane and Terry Semel Institute for Neuroscience and 
      Human Behavior, University of California, Los Angeles, CA, USA.
FAU - Narr, Katherine L
AU  - Narr KL
AD  - Department of Neurology, Brain Research Institute, University of California, Los 
      Angeles, CA, USA.
FAU - Khalsa, Dharma S
AU  - Khalsa DS
AD  - Alzheimer's Research and Prevention Foundation, Tucson, AZ, USA.
FAU - Lavretsky, Helen
AU  - Lavretsky H
AD  - Department of Psychiatry, Jane and Terry Semel Institute for Neuroscience and 
      Human Behavior, University of California, Los Angeles, CA, USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT03503669
GR  - UL1 TR001881/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
MH  - Humans
MH  - Female
MH  - Aged
MH  - *Alzheimer Disease/diagnostic imaging/therapy
MH  - *Yoga
MH  - Reproducibility of Results
MH  - Hippocampus/diagnostic imaging
MH  - Magnetic Resonance Imaging
MH  - Memory Disorders/diagnostic imaging/etiology
PMC - PMC10578221
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - cardiovascular
OT  - hippocampus
OT  - memory
OT  - resting-state
OT  - yoga
COIS- Dharma S. Khalsa is an Editorial Board Member of this journal but was not 
      involved in the peer-review process nor had access to any information regarding 
      its peer-review. All other authors have no conflict of interest to report.
EDAT- 2023/07/24 06:42
MHDA- 2023/09/05 06:42
PMCR- 2023/10/16
CRDT- 2023/07/24 04:04
PHST- 2023/09/05 06:42 [medline]
PHST- 2023/07/24 06:42 [pubmed]
PHST- 2023/07/24 04:04 [entrez]
PHST- 2023/10/16 00:00 [pmc-release]
AID - JAD221159 [pii]
AID - 10.3233/JAD-221159 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2023;95(1):149-159. doi: 10.3233/JAD-221159.