PMID- 37483239
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230725
IS  - 2470-1343 (Electronic)
IS  - 2470-1343 (Linking)
VI  - 8
IP  - 28
DP  - 2023 Jul 18
TI  - Imine-Linked Covalent Organic Frameworks: A Biocompatible and pH-Dependent 
      Carrier for In Vitro Sustained Release of Doxorubicin.
PG  - 25565-25573
LID - 10.1021/acsomega.3c03316 [doi]
AB  - Among the novel drug delivery systems (DDSs), covalent organic frameworks (COFs) 
      show promising features in pharmaceutical science. In this paper, an imine-linked 
      COF with hexagonal topology was synthesized using the autoclave condition. Then, 
      the prepared COF (APB-COF) was used as a pH-dependent carrier for in vitro 
      release of doxorubicin (DOX). The intrinsic properties of APB-COF caused reaching 
      an excellent drug encapsulation efficiency. DOX@APB-COF shows an exemplary 
      pH-dependent release in two different pHs. DOX release at pH = 7.4 was 32%, which 
      increased to 54% by changing the pH to the cancer cell pH (pH = 5.4). Moreover, 
      the cytotoxicity of APB-COF and DOX@APB-COF was studied using the standard MTT 
      test against MCF10 (normal breast cell line) and MDAmb231 cells (breast cancer 
      cell line), respectively. It was observed that the APB-COF does not affect cell 
      proliferation, whereas the DOX@APB-COF only limits cancer cell proliferation. 
      Using APB-COF as the drug carrier can pave the way for using COFs in innovative 
      DDSs.
CI  - (c) 2023 The Authors. Published by American Chemical Society.
FAU - Mokhtari, Nazanin
AU  - Mokhtari N
AD  - Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, 
      Islamic Republic of Iran.
FAU - Dinari, Mohammad
AU  - Dinari M
AUID- ORCID: 0000-0001-5291-7142
AD  - Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, 
      Islamic Republic of Iran.
FAU - Khosravi Esmaeiltarkhani, Fatemeh
AU  - Khosravi Esmaeiltarkhani F
AD  - Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, 
      Islamic Republic of Iran.
LA  - eng
PT  - Journal Article
DEP - 20230703
PL  - United States
TA  - ACS Omega
JT  - ACS omega
JID - 101691658
PMC - PMC10357574
COIS- The authors declare no competing financial interest.
EDAT- 2023/07/24 06:42
MHDA- 2023/07/24 06:43
PMCR- 2023/07/03
CRDT- 2023/07/24 04:26
PHST- 2023/05/12 00:00 [received]
PHST- 2023/06/21 00:00 [accepted]
PHST- 2023/07/24 06:43 [medline]
PHST- 2023/07/24 06:42 [pubmed]
PHST- 2023/07/24 04:26 [entrez]
PHST- 2023/07/03 00:00 [pmc-release]
AID - 10.1021/acsomega.3c03316 [doi]
PST - epublish
SO  - ACS Omega. 2023 Jul 3;8(28):25565-25573. doi: 10.1021/acsomega.3c03316. 
      eCollection 2023 Jul 18.