PMID- 37483942 OWN - NLM STAT- MEDLINE DCOM- 20230725 LR - 20230725 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 11 DP - 2023 TI - Relationship between baseline and changed serum uric acid and the incidence of type 2 diabetes mellitus: a national cohort study. PG - 1170792 LID - 10.3389/fpubh.2023.1170792 [doi] LID - 1170792 AB - OBJECTIVE: To explore the correlation between baseline serum uric acid (SUA) and SUA changes with the incidence of type 2 diabetes mellitus (T2DM) among middle-aged and older individuals. METHOD: Binary logistic regression was used to calculate the odds ratio (ORs) and 95% confidence intervals (CIs) of the effects of baseline and changes in SUA on the incidence of T2DM. Stratified analysis was conducted based on sex, and the SUA levels were classified into four quartiles to assess the effect of baseline and relative changes in SUA on the incidence of T2DM. Furthermore, interaction analysis was performed between body mass index (BMI) and SUA, age and SUA, and sex and SUA. RESULTS: In the cohort study, the highest quartiles of SUA were significantly correlated with an increased incidence of T2DM among females in model 1 [OR = 2.231 (1.631, 3.050)], model 2 [OR = 2.090 (1.523, 2.867)], model 3 [OR = 2.075 (1.511, 2.849)], and model 4 [OR = 1.707 (1.234, 2.362)]. The highest quartiles of SUA had a statistically significant effect on the incidence of T2DM among all participants in model 1 [OR = 1.601 (1.277, 2.008)], model 2 [OR = 1.519 (1.204, 1.915)], model 3 [OR = 1.597 (1.257, 2.027)], and model 4 [OR = 1.380 (1.083, 1.760)]. Regarding the relative change of SUA, the highest quantiles of SUA were significantly correlated with an increased incidence of T2DM among females in model 1 [OR = 1.409 (1.050, 1.890)], model 2 [OR = 1.433 (1.067, 1.926)], and model 3 [OR = 1.420 (1.056, 1.910)], and there was a statistically significant correlation with incident T2DM among all participants in model 4 [OR = 1.346 (1.079, 1.680)] after adjusting for all covariates. However, there was no significant correlation between baseline, relative, and absolute changes in SUA and the incidence of T2DM among males. The interaction analysis demonstrated that sex, BMI, and the relative changes in SUA had a combined effect on the incidence of T2DM, while age and the changes in SUA had a joint effect on the incidence of T2DM only in females. CONCLUSION: There was a positive association between SUA and the incidence of T2DM for all participants. However, significant sex differences in incidence were observed only in women, not men. CI - Copyright (c) 2023 Wang, Wang, Wan, Yuan, Yang, Zhang, Li, Wang, Liu, Lei, Wei, Li, Liu, Hua, Sun and Zhang. FAU - Wang, Congzhi AU - Wang C AD - Department of Internal Medicine Nursing, School of Nursing, Wannan Medical College, Higher Education Park, Wuhu, China. FAU - Wang, Jiazhi AU - Wang J AD - Sports Institute, Chi Zhou College, Education Park, Chi Zhou, China. FAU - Wan, Rui AU - Wan R AD - Business School, Yunnan University of Finance and Economics, Kunming, China. FAU - Yuan, Ting AU - Yuan T AD - Obstetrics and Gynecology Nursing, School of Nursing, Wannan Medical College, Higher Education Park, Wuhu, China. FAU - Yang, Liu AU - Yang L AD - Department of Internal Medicine Nursing, School of Nursing, Wannan Medical College, Higher Education Park, Wuhu, China. FAU - Zhang, Dongmei AU - Zhang D AD - Department of Pediatric Nursing, School of Nursing, Wannan Medical College, Higher Education Park, Wuhu, China. FAU - Li, Xiaoping AU - Li X AD - Department of Emergency and Critical Care Nursing, School of Nursing, Wannan Medical College, Higher Education Park, Wuhu, China. FAU - Wang, Min AU - Wang M AD - Department of Pharmacy, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China. FAU - Liu, Haiyang AU - Liu H AD - Student Health Center, Wannan Medical College, Higher Education Park, Wuhu, China. FAU - Lei, Yunxiao AU - Lei Y AD - Obstetrics and Gynecology Nursing, School of Nursing, Wannan Medical College, Higher Education Park, Wuhu, China. FAU - Wei, Huanhuan AU - Wei H AD - Obstetrics and Gynecology Nursing, School of Nursing, Wannan Medical College, Higher Education Park, Wuhu, China. FAU - Li, Jing AU - Li J AD - Department of Surgical Nursing, School of Nursing, Wannan Medical College, Higher Education Park, Wuhu, China. FAU - Liu, Mingming AU - Liu M AD - Department of Surgical Nursing, School of Nursing, Wannan Medical College, Higher Education Park, Wuhu, China. FAU - Hua, Ying AU - Hua Y AD - Rehabilitation Nursing, School of Nursing, Wannan Medical College, Higher Education Park, Wuhu, China. FAU - Sun, Lu AU - Sun L AD - Department of Emergency and Critical Care Nursing, School of Nursing, Wannan Medical College, Higher Education Park, Wuhu, China. FAU - Zhang, Lin AU - Zhang L AD - Department of Internal Medicine Nursing, School of Nursing, Wannan Medical College, Higher Education Park, Wuhu, China. LA - eng GR - R03 TW008358/TW/FIC NIH HHS/United States GR - R01 AG037031/AG/NIA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20230706 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 268B43MJ25 (Uric Acid) SB - IM MH - Middle Aged MH - Humans MH - Female MH - Male MH - Aged MH - *Diabetes Mellitus, Type 2/epidemiology MH - Cohort Studies MH - Uric Acid MH - Risk Factors MH - Incidence PMC - PMC10357007 OTO - NOTNLM OT - baseline OT - changes OT - cohort study OT - incidence OT - serum uric acid OT - type 2 diabetes mellitus COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/07/24 06:41 MHDA- 2023/07/25 06:43 PMCR- 2023/07/06 CRDT- 2023/07/24 04:37 PHST- 2023/02/21 00:00 [received] PHST- 2023/06/13 00:00 [accepted] PHST- 2023/07/25 06:43 [medline] PHST- 2023/07/24 06:41 [pubmed] PHST- 2023/07/24 04:37 [entrez] PHST- 2023/07/06 00:00 [pmc-release] AID - 10.3389/fpubh.2023.1170792 [doi] PST - epublish SO - Front Public Health. 2023 Jul 6;11:1170792. doi: 10.3389/fpubh.2023.1170792. eCollection 2023.