PMID- 37484678
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230725
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 14
DP  - 2023
TI  - Perceived key change phenomena of MDMA-assisted psychotherapy for the treatment 
      of severe PTSD: an interpretative phenomenological analysis of clinical 
      integration sessions.
PG  - 957824
LID - 10.3389/fpsyt.2023.957824 [doi]
LID - 957824
AB  - Post-traumatic stress disorder (PTSD) is a prevalent psychiatric condition that 
      significantly impacts daily functioning in patients but lacks adequate treatment 
      options. 3,4-methylenedioxymethamphetamine (MDMA) as an adjunct to psychotherapy 
      for the treatment of PTSD has been studied increasingly for the last two decades 
      and has shown promising results through quantitative data. However, few 
      qualitative studies have been conducted to investigate patients' experiences who 
      participate in these trials. This study intends to complement and clarify the 
      quantitative findings resulting from a Phase-II clinical trial for assessing the 
      safety and efficacy of MDMA-assisted psychotherapy for PTSD by using a 
      qualitative approach based on available material of 4 recorded and transcripted 
      integrative sessions per participant. An Interpretative Phenomenological Analysis 
      (IPA) was conducted for 7 participants who met criteria for severe PTSD to 
      develop a deeper understanding of the treatment and its efficacy. Analysis 
      results provided real-life statements from participants that reflect perceived 
      mechanisms of change and showed to what extent their proposed working mechanisms 
      integrate into daily life.
CI  - Copyright (c) 2023 Godes, Lucas and Vermetten.
FAU - Godes, Macha
AU  - Godes M
AD  - Institute of Psychology, Social Science Department, University of Amsterdam, 
      Amsterdam, Netherlands.
FAU - Lucas, Jasper
AU  - Lucas J
AD  - Institute of Psychology, Social Science Department, Leiden University, Leiden, 
      Netherlands.
FAU - Vermetten, Eric
AU  - Vermetten E
AD  - Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20230707
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC10361411
OTO - NOTNLM
OT  - MDMA
OT  - MDMA-assisted psychotherapy
OT  - PTSD
OT  - interpretative phenomenological analyses
OT  - psychedelics
OT  - psychotherapy
OT  - qualitative research
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/07/24 06:43
MHDA- 2023/07/24 06:44
PMCR- 2023/07/07
CRDT- 2023/07/24 04:46
PHST- 2022/05/31 00:00 [received]
PHST- 2023/05/10 00:00 [accepted]
PHST- 2023/07/24 06:44 [medline]
PHST- 2023/07/24 06:43 [pubmed]
PHST- 2023/07/24 04:46 [entrez]
PHST- 2023/07/07 00:00 [pmc-release]
AID - 10.3389/fpsyt.2023.957824 [doi]
PST - epublish
SO  - Front Psychiatry. 2023 Jul 7;14:957824. doi: 10.3389/fpsyt.2023.957824. 
      eCollection 2023.