PMID- 37485025
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230725
IS  - 2234-8646 (Print)
IS  - 2234-8840 (Electronic)
IS  - 2234-8840 (Linking)
VI  - 26
IP  - 4
DP  - 2023 Jul
TI  - Association Between Pediatric Gastroesophageal Reflux Disease Symptom and Quality 
      of Life Questionnaire Score, Endoscopy and Biopsy in Children with Clinical 
      Gastroesophageal Reflux Disease: A Prospective Study.
PG  - 173-180
LID - 10.5223/pghn.2023.26.4.173 [doi]
AB  - PURPOSE: Gastro esophageal reflux disease (GERD) is a burdensome disease 
      affecting many children. A clinical examination is reported to be unreliable to 
      diagnose GERD in children. This study aimed to investigate the relationship 
      between the Pediatric Gastroesophageal Reflux Disease Symptom and Quality of Life 
      Questionnaire (PGSQ) and endoscopic and histopathological findings in children 
      with symptoms suggesting GERD. Changes in the PGSQ score in children with 
      esophagitis as response to one month therapy were recorded as secondary outcome. 
      METHODS: This is a prospective cohort study in the pediatric outpatient clinic in 
      an Indonesian tertiary hospital. Children aged 2-17 years old with clinical 
      symptoms suspected of GERD are included in the study. Blinded endoscopic and 
      histopathological examination was performed in all patients before one month 
      proton pump inhibitors (PPI) therapy. The PGSQ information was collected at 
      inclusion and after one month PPI treatment. RESULTS: Fifty-eight subjects were 
      included. Esophagitis was found in 60.9% of subjects according to endoscopy and 
      58.6% according to histology. There was no significant relationship between the 
      PGSQ score and endoscopic (p=0.781) nor biopsy (p=0.740) examinations. The PGSQ 
      showed a low diagnostic value compared to endoscopy and biopsy (area under the 
      curve [AUC] 0.477, p=0.477, 95% confidence interval [CI] 0.326-0.629 and AUC 
      0.474, p=0.740 (95% CI 0.321-0.627 respectively). The PGSQ improved significantly 
      post one month of PPI treatment. CONCLUSION: The PGSQ cannot be used to diagnose 
      esophagitis in children with clinical symptoms suggesting GERD. However, the PGSQ 
      can be used to monitor the treatment response in children with esophagitis.
CI  - Copyright (c) 2023 by The Korean Society of Pediatric Gastroenterology, Hepatology 
      and Nutrition.
FAU - Alatas, Fatima Safira
AU  - Alatas FS
AUID- ORCID: 0000-0003-1299-7154
AD  - Department of Child Health, Faculty of Medicine, Universitas Indonesia, Cipto 
      Mangunkusomo Hospital, Jakarta, Indonesia.
FAU - Pertiwi, Dian Wulandaru Sukmaning
AU  - Pertiwi DWS
AUID- ORCID: 0000-0002-8476-1696
AD  - Department of Child Health, Faculty of Medicine, Universitas Indonesia, Cipto 
      Mangunkusomo Hospital, Jakarta, Indonesia.
FAU - Kadim, Muzal
AU  - Kadim M
AUID- ORCID: 0000-0003-2512-255X
AD  - Department of Child Health, Faculty of Medicine, Universitas Indonesia, Cipto 
      Mangunkusomo Hospital, Jakarta, Indonesia.
FAU - Dwipoerwantoro, Pramita
AU  - Dwipoerwantoro P
AUID- ORCID: 0000-0003-3755-3808
AD  - Department of Child Health, Faculty of Medicine, Universitas Indonesia, Cipto 
      Mangunkusomo Hospital, Jakarta, Indonesia.
FAU - Oswari, Hanifah
AU  - Oswari H
AUID- ORCID: 0000-0003-4310-5841
AD  - Department of Child Health, Faculty of Medicine, Universitas Indonesia, Cipto 
      Mangunkusomo Hospital, Jakarta, Indonesia.
FAU - Hegar, Badriul
AU  - Hegar B
AUID- ORCID: 0000-0002-5924-1664
AD  - Department of Child Health, Faculty of Medicine, Universitas Indonesia, Cipto 
      Mangunkusomo Hospital, Jakarta, Indonesia.
FAU - Vandenplas, Yvan
AU  - Vandenplas Y
AUID- ORCID: 0000-0002-1862-8651
AD  - Vrije Universiteit Brussel, UZ Brussel, KidZ Health Castle, Brussels, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20230705
PL  - Korea (South)
TA  - Pediatr Gastroenterol Hepatol Nutr
JT  - Pediatric gastroenterology, hepatology & nutrition
JID - 101590471
PMC - PMC10356974
OTO - NOTNLM
OT  - Endoscopy
OT  - Esophagitis
OT  - Gastro-esophageal reflux
OT  - Gastroscopy
OT  - Histology
OT  - Pediatric Gastroesophageal Reflux Disease Symptom and Quality of Life 
      Questionnaire
COIS- Conflict of Interest: The authors have no financial conflicts of interest.
EDAT- 2023/07/24 06:42
MHDA- 2023/07/24 06:43
PMCR- 2023/07/01
CRDT- 2023/07/24 04:52
PHST- 2022/11/09 00:00 [received]
PHST- 2023/02/19 00:00 [revised]
PHST- 2023/05/10 00:00 [accepted]
PHST- 2023/07/24 06:43 [medline]
PHST- 2023/07/24 06:42 [pubmed]
PHST- 2023/07/24 04:52 [entrez]
PHST- 2023/07/01 00:00 [pmc-release]
AID - 10.5223/pghn.2023.26.4.173 [doi]
PST - ppublish
SO  - Pediatr Gastroenterol Hepatol Nutr. 2023 Jul;26(4):173-180. doi: 
      10.5223/pghn.2023.26.4.173. Epub 2023 Jul 5.