PMID- 37486190 OWN - NLM STAT- MEDLINE DCOM- 20231211 LR - 20231211 IS - 2724-5438 (Electronic) IS - 2724-5691 (Linking) VI - 78 IP - 6 DP - 2023 Dec TI - Long-term patient-reported outcomes after anti-reflux surgery for gastroesophageal reflux disease and hiatal hernia repair: a single-center experience. PG - 638-643 LID - 10.23736/S2724-5691.23.09930-6 [doi] AB - BACKGROUND: Patients with gastroesophageal reflux disease (GERD) and hiatal hernia who are candidates for surgery should be treated with minimally invasive partial or total fundoplication. As data on long-term clinical and functional outcomes after laparoscopic surgery for GERD are limited, the aim of this study was to evaluate the long-term effectiveness of fundoplication in terms of patient-reported symptoms and proton pump inhibitor (PPI) use. METHODS: The data of 88 patients who underwent laparoscopic anti-reflux surgery for GERD between January 2007 and September 2020 were retrospectively reviewed. Preoperative and postoperative patient-reported outcomes were investigated after surgery using a 13-items Likert-Scale questionnaire based on the frequency (events/week) and severity of typical and atypical symptoms, dysphagia, and dyspepsia. Furthermore, variations in the use of PPIs were investigated as a secondary endpoint. RESULTS: A total of 76 patients participated in the questionnaire survey. The median follow-up duration was 77 (2-165) months. The postoperative rate of mild and severe typical symptoms was significantly lower than the preoperative rate (P<0.01). Similarly, the atypical symptom rates decreased after surgery (P<0.05). Dysphagia was more frequent after fundoplication (P<0.01). Before the anti-reflux surgery, 94.7% of the patients were prescribed a PPI. At the time of follow-up, this proportion had decreased to 73.7% (P<0.01). However, the PPI intake rate was 90.9% in the group of patients interviewed >10 years after surgery. CONCLUSIONS: In this cohort of patients, laparoscopic anti-reflux fundoplication reduced the rate typical and atypical symptoms of GERD. However, surgery appeared to have no impact on PPI intake over time. FAU - Peltrini, Roberto AU - Peltrini R AD - Department of Public Health, Federico II University Hospital, Naples, Italy. FAU - Carannante, Filippo AU - Carannante F AD - Unit of Colorectal Surgery, Department of Surgery, Campus Bio-Medico University Hospital, Rome, Italy - f.carannante@policlinicocampus.it. FAU - Giovine, Gennaro AU - Giovine G AD - Department of Public Health, Federico II University Hospital, Naples, Italy. FAU - Petitti, Tommasangelo AU - Petitti T AD - Department of Hygiene, Public Health and Statistics, Campus Bio-Medico University, Rome, Italy. FAU - LA Vaccara, Vincenzo AU - LA Vaccara V AD - Unit of General Surgery, Campus Bio-Medico University Hospital, Rome, Italy. FAU - Caricato, Marco AU - Caricato M AD - Unit of Colorectal Surgery, Department of Surgery, Campus Bio-Medico University Hospital, Rome, Italy. FAU - Capolupo, Gabriella T AU - Capolupo GT AD - Unit of Colorectal Surgery, Department of Surgery, Campus Bio-Medico University Hospital, Rome, Italy. FAU - Borzomati, Domenico AU - Borzomati D AD - Unit of Colorectal Surgery, Department of Surgery, Campus Bio-Medico University Hospital, Rome, Italy. LA - eng PT - Journal Article DEP - 20230724 PL - Italy TA - Minerva Surg JT - Minerva surgery JID - 101777295 RN - 0 (Proton Pump Inhibitors) SB - IM MH - Humans MH - *Deglutition Disorders/complications/drug therapy MH - Retrospective Studies MH - Herniorrhaphy MH - Treatment Outcome MH - *Gastroesophageal Reflux/drug therapy/surgery/complications MH - Proton Pump Inhibitors/therapeutic use EDAT- 2023/07/24 13:08 MHDA- 2023/12/11 12:42 CRDT- 2023/07/24 09:40 PHST- 2023/12/11 12:42 [medline] PHST- 2023/07/24 13:08 [pubmed] PHST- 2023/07/24 09:40 [entrez] AID - S2724-5691.23.09930-6 [pii] AID - 10.23736/S2724-5691.23.09930-6 [doi] PST - ppublish SO - Minerva Surg. 2023 Dec;78(6):638-643. doi: 10.23736/S2724-5691.23.09930-6. Epub 2023 Jul 24.