PMID- 37486444
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230727
IS  - 2197-1153 (Print)
IS  - 2197-1153 (Electronic)
IS  - 2197-1153 (Linking)
VI  - 10
IP  - 1
DP  - 2023 Jul 24
TI  - Dynamic intermittent compression cryotherapy with intravenous nefopam results in 
      faster pain recovery than static compression cryotherapy with oral nefopam: 
      post-anterior cruciate ligament reconstruction.
PG  - 72
LID - 10.1186/s40634-023-00639-3 [doi]
LID - 72
AB  - PURPOSE: To evaluate the effectiveness of dynamic intermittent compression 
      cryotherapy (DICC) (CryoNov(R)) with an intravenous nefopam-based pain management 
      protocol (DCIVNPP) in reducing post-operative pain following anterior cruciate 
      ligament reconstruction (ACLR) compared to static compression cryotherapy (SCC) 
      (Igloo(R)) and oral Nefopam. METHODS: This was a retrospective analysis of 
      prospectively collected data including 676 patients who underwent primary ACLR in 
      2022. Patients were either in the DCIVNPP group or in the SCC (control group), 
      and were matched for age, sex, and Lysholm and Tegner scores (338 per arm). The 
      primary outcome was pain on the visual analogue scale (VAS), analyzed in relation 
      to the minimal clinically important difference (MCID) and the Patient Acceptable 
      Symptom State (PASS) thresholds for VAS. The secondary outcome was side effects. 
      RESULTS: Postoperative pain in the DCIVNPP group was less severe on the VAS than 
      in the control group (p < 0.05). The maximum difference in the VAS between groups 
      was 0.57, which is less than the MCID threshold for VAS. The DCIVNPP group 
      crossed the PASS threshold for VAS on Day 3, sooner than the control group. The 
      side effect profiles were similar in both groups except for higher rates of 
      dizziness and malaise in the DCIVNPP group, and higher rates of abdominal pain in 
      the control group. Most of the side effects decreased over time in both groups, 
      with no significant side effects after Day 3. CONCLUSION: DCIVNPP effectively 
      allows for faster pain recovery than in the control group. The difference in side 
      effects between the protocols may be due to mode of administration of nefopam. 
      LEVEL OF EVIDENCE: III.
CI  - (c) 2023. The Author(s).
FAU - Moussa, Mohamad K
AU  - Moussa MK
AD  - Department of Sports Surgery, Clinique du Sport, 75005, Paris, France. 
      mhamadmoussa71976798@gmail.com.
FAU - Lefevre, Nicolas
AU  - Lefevre N
AD  - Department of Sports Surgery, Clinique du Sport, 75005, Paris, France.
FAU - Valentin, Eugenie
AU  - Valentin E
AD  - Department of Sports Surgery, Clinique du Sport, 75005, Paris, France.
FAU - Meyer, Alain
AU  - Meyer A
AD  - Department of Sports Surgery, Clinique du Sport, 75005, Paris, France.
FAU - Grimaud, Olivier
AU  - Grimaud O
AD  - Department of Sports Surgery, Clinique du Sport, 75005, Paris, France.
FAU - Bohu, Yoan
AU  - Bohu Y
AD  - Department of Sports Surgery, Clinique du Sport, 75005, Paris, France.
FAU - Gerometta, Antoinne
AU  - Gerometta A
AD  - Department of Sports Surgery, Clinique du Sport, 75005, Paris, France.
FAU - Khiami, Frederic
AU  - Khiami F
AD  - Department of Sports Surgery, Clinique du Sport, 75005, Paris, France.
FAU - Hardy, Alexandre
AU  - Hardy A
AD  - Department of Sports Surgery, Clinique du Sport, 75005, Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20230724
PL  - United States
TA  - J Exp Orthop
JT  - Journal of experimental orthopaedics
JID - 101653750
PMC - PMC10366045
OTO - NOTNLM
OT  - ACL reconstruction
OT  - Cryotherapy
OT  - Dynamic compression cryotherapy
OT  - Early recovery
OT  - Morphine-free analgesia
OT  - PASS
OT  - Static cryotherapy
COIS- NL: Consultant at Websurvey Society, Paris France. AH: Consultant for Arthrex and 
      Depuy.
EDAT- 2023/07/24 13:06
MHDA- 2023/07/24 13:07
PMCR- 2023/07/24
CRDT- 2023/07/24 11:10
PHST- 2023/05/11 00:00 [received]
PHST- 2023/07/18 00:00 [accepted]
PHST- 2023/07/24 13:07 [medline]
PHST- 2023/07/24 13:06 [pubmed]
PHST- 2023/07/24 11:10 [entrez]
PHST- 2023/07/24 00:00 [pmc-release]
AID - 10.1186/s40634-023-00639-3 [pii]
AID - 639 [pii]
AID - 10.1186/s40634-023-00639-3 [doi]
PST - epublish
SO  - J Exp Orthop. 2023 Jul 24;10(1):72. doi: 10.1186/s40634-023-00639-3.