PMID- 37488041
OWN - NLM
STAT- MEDLINE
DCOM- 20230828
LR  - 20230828
IS  - 1095-9947 (Electronic)
IS  - 1050-4648 (Linking)
VI  - 140
DP  - 2023 Sep
TI  - Identification and characterization of tryptophan-kynurenine pathway-related 
      genes involving lamprey (Lampetra japonica) innate immunity.
PG  - 108967
LID - S1050-4648(23)00453-9 [pii]
LID - 10.1016/j.fsi.2023.108967 [doi]
AB  - The tryptophan-kynurenine (TRP-KYN) pathway is involved in several biological 
      functions, including immunosuppression, inflammatory response, and tumor 
      suppression. Six TRP-KYN pathway-related genes, tryptophan 2,3-dioxygenase (TDO), 
      indoleamine 2,3-dioxygenase 2 (IDO2), aminoadipate aminotransferase (AADAT), 
      glutamate oxaloacetate transaminase 2 (GOT2), kynurenine monooxygenase (KMO), and 
      kynureninase (KYNU) have been identified and cloned from the jawless vertebrate 
      lamprey (Lampetra japonica) to gain insights into their evolution and 
      characterization. Expression distribution showed that the key gene Lj-TDO was 
      highly expressed in the oral gland. Real-time quantitative PCR showed that 
      TRP-KYN pathway-related genes were significantly overexpressed after 
      multi-stimulation. RNA interference showed that Lj-IDO2 knockdown regulated the 
      expression of inflammatory factors. In conclusion, our study successfully 
      clarified the ancestral features and functions of the TRP-KYN pathway, while 
      providing valuable insights into the involvement of this pathway in the immune 
      responses of a jawless vertebrate.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Luan, Yimu
AU  - Luan Y
AD  - College of Life Science, Liaoning Normal University, Dalian, 116081, China; 
      Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China; 
      Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic 
      University, Dalian, 116034, China.
FAU - Wang, Yaocen
AU  - Wang Y
AD  - College of Life Science, Liaoning Normal University, Dalian, 116081, China; 
      Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China; 
      Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic 
      University, Dalian, 116034, China.
FAU - Zhang, Wentong
AU  - Zhang W
AD  - College of Life Science, Liaoning Normal University, Dalian, 116081, China; 
      Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China; 
      Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic 
      University, Dalian, 116034, China.
FAU - Duan, Xuyuan
AU  - Duan X
AD  - College of Life Science, Liaoning Normal University, Dalian, 116081, China; 
      Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China; 
      Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic 
      University, Dalian, 116034, China.
FAU - Su, Peng
AU  - Su P
AD  - College of Life Science, Liaoning Normal University, Dalian, 116081, China; 
      Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China; 
      Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic 
      University, Dalian, 116034, China.
FAU - Li, Qingwei
AU  - Li Q
AD  - College of Life Science, Liaoning Normal University, Dalian, 116081, China; 
      Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China; 
      Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic 
      University, Dalian, 116034, China.
FAU - Pang, Yue
AU  - Pang Y
AD  - College of Life Science, Liaoning Normal University, Dalian, 116081, China; 
      Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China; 
      Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic 
      University, Dalian, 116034, China. Electronic address: pangyue@lnnu.edu.cn.
FAU - Gou, Meng
AU  - Gou M
AD  - College of Life Science, Liaoning Normal University, Dalian, 116081, China; 
      Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China; 
      Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic 
      University, Dalian, 116034, China. Electronic address: gouer602@lnnu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230723
PL  - England
TA  - Fish Shellfish Immunol
JT  - Fish & shellfish immunology
JID - 9505220
RN  - 8DUH1N11BX (Tryptophan)
RN  - 343-65-7 (Kynurenine)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
SB  - IM
MH  - Animals
MH  - *Tryptophan/metabolism
MH  - *Kynurenine/analysis/metabolism
MH  - Lampreys/genetics/metabolism
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/genetics
MH  - Immunity, Innate/genetics
OTO - NOTNLM
OT  - Immune function
OT  - Indoleamine 2,3-dioxygenase (IDO)
OT  - Lampetra japonica
OT  - Tryptophan 2,3-dioxygenase (TDO)
OT  - Tryptophan-kynurenine pathway
COIS- Declaration of competing interest The authors declare no conflict of interest.
EDAT- 2023/07/25 01:09
MHDA- 2023/08/28 06:42
CRDT- 2023/07/24 22:04
PHST- 2023/05/16 00:00 [received]
PHST- 2023/07/17 00:00 [revised]
PHST- 2023/07/20 00:00 [accepted]
PHST- 2023/08/28 06:42 [medline]
PHST- 2023/07/25 01:09 [pubmed]
PHST- 2023/07/24 22:04 [entrez]
AID - S1050-4648(23)00453-9 [pii]
AID - 10.1016/j.fsi.2023.108967 [doi]
PST - ppublish
SO  - Fish Shellfish Immunol. 2023 Sep;140:108967. doi: 10.1016/j.fsi.2023.108967. Epub 
      2023 Jul 23.