PMID- 37488618
OWN - NLM
STAT- MEDLINE
DCOM- 20230727
LR  - 20230727
IS  - 1756-3305 (Electronic)
IS  - 1756-3305 (Linking)
VI  - 16
IP  - 1
DP  - 2023 Jul 24
TI  - Tick salivary gland components dampen Kasokero virus infection and shedding in 
      its vertebrate reservoir, the Egyptian rousette bat (Rousettus aegyptiacus).
PG  - 249
LID - 10.1186/s13071-023-05853-7 [doi]
LID - 249
AB  - BACKGROUND: The human-pathogenic Kasokero virus (KASV) circulates in an enzootic 
      transmission cycle between Egyptian rousette bats (ERBs; Rousettus aegyptiacus) 
      and their argasid tick ectoparasites, Ornithodoros (Reticulinasus) faini. 
      Although tick salivary gland components have been shown to potentiate virus 
      infection in vertebrate non-reservoirs (i.e. incidental hosts or small animal 
      models of disease), there is a lack of information on the effect of tick salivary 
      gland components on viral infection and shedding in vertebrate reservoirs. 
      METHODS: To determine the impact of tick salivary gland components on KASV 
      infection and shedding in ERBs, KASV loads were quantified in blood, oral swab, 
      rectal swab, and urine specimens collected daily through 18 days post inoculation 
      from groups of ERBs intradermally inoculated with KASV or KASV + O. (R.) faini 
      tick salivary gland extract (SGE). RESULTS: Bats inoculated with KASV + tick SGE 
      had significantly lower peak and cumulative KASV viremias and rectal shedding 
      loads compared to bats inoculated with KASV only. CONCLUSIONS: We report for the 
      first time to our knowledge that tick salivary gland components dampen arbovirus 
      infection and shedding in a vertebrate reservoir. This study advances our 
      understanding of biological factors underlying arbovirus maintenance in nature.
CI  - (c) 2023. This is a U.S. Government work and not under copyright protection in the 
      US; foreign copyright protection may apply.
FAU - Schuh, Amy J
AU  - Schuh AJ
AD  - Viral Special Pathogens Branch, Division of High-Consequence Pathogens and 
      Pathology, National Center for Emerging and Zoonotic Infectious Diseases, United 
      States Centers for Disease Control and Prevention, Atlanta, GA, USA. 
      wuc2@cdc.gov.
AD  - United States Public Health Service Commissioned Corps, Rockville, MD, USA. 
      wuc2@cdc.gov.
FAU - Amman, Brian R
AU  - Amman BR
AD  - Viral Special Pathogens Branch, Division of High-Consequence Pathogens and 
      Pathology, National Center for Emerging and Zoonotic Infectious Diseases, United 
      States Centers for Disease Control and Prevention, Atlanta, GA, USA.
FAU - Guito, Jonathan C
AU  - Guito JC
AD  - Viral Special Pathogens Branch, Division of High-Consequence Pathogens and 
      Pathology, National Center for Emerging and Zoonotic Infectious Diseases, United 
      States Centers for Disease Control and Prevention, Atlanta, GA, USA.
FAU - Graziano, James C
AU  - Graziano JC
AD  - Viral Special Pathogens Branch, Division of High-Consequence Pathogens and 
      Pathology, National Center for Emerging and Zoonotic Infectious Diseases, United 
      States Centers for Disease Control and Prevention, Atlanta, GA, USA.
FAU - Sealy, Tara K
AU  - Sealy TK
AD  - Viral Special Pathogens Branch, Division of High-Consequence Pathogens and 
      Pathology, National Center for Emerging and Zoonotic Infectious Diseases, United 
      States Centers for Disease Control and Prevention, Atlanta, GA, USA.
FAU - Towner, Jonathan S
AU  - Towner JS
AD  - Viral Special Pathogens Branch, Division of High-Consequence Pathogens and 
      Pathology, National Center for Emerging and Zoonotic Infectious Diseases, United 
      States Centers for Disease Control and Prevention, Atlanta, GA, USA. 
      jit8@cdc.gov.
LA  - eng
GR  - HDTRA 1033037/Defense Threat Reduction Agency/
GR  - HDTRA 1033037/Defense Threat Reduction Agency/
GR  - HDTRA 1033037/Defense Threat Reduction Agency/
GR  - HDTRA 1033037/Defense Threat Reduction Agency/
GR  - HDTRA 1033037/Defense Threat Reduction Agency/
GR  - HDTRA 1033037/Defense Threat Reduction Agency/
PT  - Journal Article
DEP - 20230724
PL  - England
TA  - Parasit Vectors
JT  - Parasites & vectors
JID - 101462774
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Chiroptera
MH  - *Marburgvirus
MH  - Salivary Glands
MH  - *Ornithodoros
MH  - Viremia
PMC - PMC10367358
OTO - NOTNLM
OT  - Chiroptera
OT  - Host interactions
OT  - Infection
OT  - Infectious disease reservoir
OT  - Insect vectors
OT  - Saliva
OT  - Ticks
OT  - Vector-borne diseases
OT  - Virus
OT  - Viruses
OT  - Zoonoses
COIS- The authors declare that they have no competing interests.
EDAT- 2023/07/25 01:09
MHDA- 2023/07/27 06:42
PMCR- 2023/07/24
CRDT- 2023/07/24 23:47
PHST- 2023/04/21 00:00 [received]
PHST- 2023/06/27 00:00 [accepted]
PHST- 2023/07/27 06:42 [medline]
PHST- 2023/07/25 01:09 [pubmed]
PHST- 2023/07/24 23:47 [entrez]
PHST- 2023/07/24 00:00 [pmc-release]
AID - 10.1186/s13071-023-05853-7 [pii]
AID - 5853 [pii]
AID - 10.1186/s13071-023-05853-7 [doi]
PST - epublish
SO  - Parasit Vectors. 2023 Jul 24;16(1):249. doi: 10.1186/s13071-023-05853-7.