PMID- 37488801
OWN - NLM
STAT- MEDLINE
DCOM- 20230726
LR  - 20230727
IS  - 1673-4254 (Print)
IS  - 2663-0842 (Electronic)
IS  - 1673-4254 (Linking)
VI  - 43
IP  - 7
DP  - 2023 Jul 20
TI  - [STIP1 correlates with tumor immune infiltration and prognosis as a potential 
      immunotherapy target: a pan-cancer bioinformatics analysis].
PG  - 1179-1193
LID - 10.12122/j.issn.1673-4254.2023.07.15 [doi]
AB  - OBJECTIVE: To investigate the correlation of stress-inducible phosphoprotein 1 
      (STIP1) expression level with prognosis of different cancers and its potential 
      role in immunotherapy. METHODS: TCGA, TARGET and GTEx databases were used for 
      bioinformatic analysis of STIP1 expression level and its prognostic value in 
      different cancers. We also detected STIP1 expression immunohistochemically in 10 
      pairs of colorectal cancer and adjacent tissues. We further analyzed the 
      correlation of STIP1 expression level with tumor mutational burden, 
      microsatellite instability, immune cell infiltration, immune regulators and 
      outcomes of different cancers. STIP1- related proteins were identified using 
      protein- protein interaction (PPI) network analysis, and functional enrichment 
      analysis was performed to analyze the regulatory pathways involving STIP1. 
      RESULTS: Bioinformatics analysis showed that STIP1 was highly expressed in most 
      tumors compared with the normal tissues (P < 0.05), which was confirmed by 
      immunohistochemistry of the 10 pairs of colorectal cancer tissues. STIP1 
      expression level was correlated with clinical stages of multiple cancers (P < 
      0.05), and in some cancer types, an upregulated STIP1 expression was correlated 
      with a poor prognosis of the patients in terms of overall survival, 
      disease-specific survival, disease-free survival and progression-free survival (P 
      < 0.05). STIP1 expression was significantly correlated with tumor mutational 
      burden, microsatellite instability, immune cell infiltration and immunomodulatory 
      factors in most tumors (P < 0.05). PPI network analysis indicated that 
      STIP1-related proteins included HSPA4, HSPA8, and HSP90AA1. KEGG enrichment 
      analysis suggested that the high expression of STIP1 in liver cancer was related 
      mainly with valerate metabolism, tryptophan metabolism, and butyrate metabolism 
      pathways; HALLMARK enrichment analysis suggested high STIP1 expression in liver 
      cancer was involved in bile acid and fatty acid metabolism. CONCLUSION: STIP1 is 
      up-regulated in multiple cancer types and its expression level is correlated with 
      clinical tumor stage, tumor mutational burden, microsatellite instability, immune 
      cell infiltration and immunomodulatory factors.
FAU - Guan, S
AU  - Guan S
AD  - Department of General Surgery, Nanfang Hospital, Southern Medical University, 
      Guangzhou 510515, China.
FAU - Shen, Z
AU  - Shen Z
AD  - Department of General Surgery, Nanfang Hospital, Southern Medical University, 
      Guangzhou 510515, China.
FAU - Lin, M
AU  - Lin M
AD  - Department of General Surgery, Nanfang Hospital, Southern Medical University, 
      Guangzhou 510515, China.
FAU - Deng, H
AU  - Deng H
AD  - Department of General Surgery, Nanfang Hospital, Southern Medical University, 
      Guangzhou 510515, China.
FAU - Fang, Y
AU  - Fang Y
AD  - Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 
      Guangzhou 510515, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (STIP1 protein, human)
SB  - IM
MH  - Humans
MH  - Microsatellite Instability
MH  - *Liver Neoplasms
MH  - Immunotherapy
MH  - Prognosis
MH  - Computational Biology
MH  - Heat-Shock Proteins
MH  - *Colorectal Neoplasms
PMC - PMC10366520
OTO - NOTNLM
OT  - immune-related gene
OT  - pan-cancer analysis
OT  - stress induced phosphoprotein 1
OT  - stress-inducible phosphoprotein 1
EDAT- 2023/07/25 06:43
MHDA- 2023/07/26 06:42
PMCR- 2023/07/20
CRDT- 2023/07/25 01:05
PHST- 2023/07/26 06:42 [medline]
PHST- 2023/07/25 06:43 [pubmed]
PHST- 2023/07/25 01:05 [entrez]
PHST- 2023/07/20 00:00 [pmc-release]
AID - nfykdxxb-43-7-1179 [pii]
AID - 10.12122/j.issn.1673-4254.2023.07.15 [doi]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2023 Jul 20;43(7):1179-1193. doi: 
      10.12122/j.issn.1673-4254.2023.07.15.