PMID- 37489049 OWN - NLM STAT- MEDLINE DCOM- 20231204 LR - 20231217 IS - 1398-9995 (Electronic) IS - 0105-4538 (Linking) VI - 78 IP - 12 DP - 2023 Dec TI - Immunoglobulin E autoantibodies in atopic dermatitis associate with Type-2 comorbidities and the atopic march. PG - 3178-3192 LID - 10.1111/all.15822 [doi] AB - BACKGROUND: Autoreactive immunoglobulin E (IgE) antibodies to self-peptides within the epidermis have been identified in patients with atopic dermatitis (AD). Prevalence, concomitant diseases, patient characteristics, and risk factors of IgE autoantibody development remain elusive. We aimed to determine IgE autoantibodies in serum samples (n = 672) from well-characterized patients with AD and controls (1.2-88.9 years). METHODS: Atopic dermatitis patients were sub-grouped in AD with comorbid Type-2 diseases ("AD + Type 2"; asthma, allergic rhinitis, food allergy, n = 431) or "solely AD" (n = 115). Also, subjects without AD but with Type-2 diseases ("atopic controls," n = 52) and non-atopic "healthy controls" (n = 74) were included. Total proteins from primary human keratinocytes were used for the immunoassay to detect IgE autoantibodies. Values were compared to already known positive and negative serum samples. RESULTS: Immunoglobulin E autoantibodies were found in 15.0% (82/546) of all analyzed AD-patients. "AD + Type 2" showed a higher prevalence (16.4%) than "solely AD" (9.6%). "Atopic controls" (9.6%) were comparable with "solely AD" patients, while 2.7% of healthy controls showed IgE autoantibodies. Of those with high levels of IgE autoantibodies, 15 out of 16 were patients with "AD + Type 2". AD patients with IgE autoantibodies were younger than those without. Patients with IgE autoreactivity also displayed higher total serum IgE levels. Factors that affected IgE autoantibody development were as follows: birth between January and June, cesarean-section and diversity of domestic pets. CONCLUSIONS: Immunoglobulin E autoantibodies in AD seem to associate with the presence of atopic comorbidities and environmental factors. The potential value of IgE autoantibodies as a predictive biomarker for the course of AD, including the atopic march, needs further exploration. CI - (c) 2023 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. FAU - Kortekaas Krohn, Inge AU - Kortekaas Krohn I AUID- ORCID: 0000-0003-3649-1131 AD - Skin Immunology & Immune Tolerance (SKIN) Research Group, Vrije Universiteit Brussel (VUB), Brussels, Belgium. AD - Department of Dermatology, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium. FAU - Badloe, Fariza Mishaal Saiema AU - Badloe FMS AUID- ORCID: 0000-0002-4881-6450 AD - Skin Immunology & Immune Tolerance (SKIN) Research Group, Vrije Universiteit Brussel (VUB), Brussels, Belgium. AD - Department of Dermatology, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium. FAU - Herrmann, Nadine AU - Herrmann N AUID- ORCID: 0000-0003-4924-2281 AD - Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany. AD - Christine Kuhne-Center for Allergy Research and Education, Davos, Switzerland. FAU - Maintz, Laura AU - Maintz L AUID- ORCID: 0000-0001-6053-1530 AD - Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany. AD - Christine Kuhne-Center for Allergy Research and Education, Davos, Switzerland. FAU - De Vriese, Shauni AU - De Vriese S AUID- ORCID: 0000-0003-2666-238X AD - Skin Immunology & Immune Tolerance (SKIN) Research Group, Vrije Universiteit Brussel (VUB), Brussels, Belgium. AD - Department of Dermatology, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium. FAU - Ring, Johannes AU - Ring J AUID- ORCID: 0000-0001-8236-3152 AD - Department Dermatology and Allergy Biederstein, Technical University Munich, Munich, Germany. CN - CK-CARE Study Group FAU - Bieber, Thomas AU - Bieber T AUID- ORCID: 0000-0002-8800-3817 AD - Department of Dermatology and Allergy, University Hospital Bonn, Bonn, Germany. AD - Christine Kuhne-Center for Allergy Research and Education, Davos, Switzerland. AD - Davos Biosciences, Davos, Switzerland. FAU - Gutermuth, Jan AU - Gutermuth J AUID- ORCID: 0000-0002-5805-3784 AD - Skin Immunology & Immune Tolerance (SKIN) Research Group, Vrije Universiteit Brussel (VUB), Brussels, Belgium. AD - Department of Dermatology, Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussels, Belgium. LA - eng GR - 12W2219N/Fonds Wetenschappelijk Onderzoek/ GR - 0000000122/Sanofi Genzyme/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230724 PL - Denmark TA - Allergy JT - Allergy JID - 7804028 RN - 0 (Autoantibodies) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - *Dermatitis, Atopic/diagnosis/epidemiology MH - Autoantibodies MH - Immunoglobulin E MH - *Asthma MH - Keratinocytes OTO - NOTNLM OT - IgE-mediated autoreactivity OT - Type-2 diseases OT - atopic dermatitis OT - autoantibodies OT - autoreactive IgE FIR - Schmid-Grendelmeier, Peter IR - Schmid-Grendelmeier P FIR - Traidl-Hoffmann, Claudia IR - Traidl-Hoffmann C FIR - Akdis, Cezmi IR - Akdis C FIR - Lauener, Roger IR - Lauener R FIR - Bruggen, Marie-Charlotte IR - Bruggen MC FIR - Rhyner, Claudio IR - Rhyner C FIR - Bersuch, Eugen IR - Bersuch E FIR - Dreher, Anita IR - Dreher A FIR - Hammel, Gertrud IR - Hammel G FIR - Luschkova, Daria IR - Luschkova D FIR - Lang, Claudia IR - Lang C FIR - Reiger, Matthias IR - Reiger M EDAT- 2023/07/25 06:43 MHDA- 2023/12/04 12:42 CRDT- 2023/07/25 02:53 PHST- 2023/05/24 00:00 [revised] PHST- 2022/11/19 00:00 [received] PHST- 2023/06/12 00:00 [accepted] PHST- 2023/12/04 12:42 [medline] PHST- 2023/07/25 06:43 [pubmed] PHST- 2023/07/25 02:53 [entrez] AID - 10.1111/all.15822 [doi] PST - ppublish SO - Allergy. 2023 Dec;78(12):3178-3192. doi: 10.1111/all.15822. Epub 2023 Jul 24.