PMID- 37489301
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230727
IS  - 2411-5142 (Electronic)
IS  - 2411-5142 (Linking)
VI  - 8
IP  - 3
DP  - 2023 Jun 22
TI  - Acute Effect of L-Citrulline Supplementation on Resistance Exercise Performance 
      and Muscle Oxygenation in Recreationally Resistance Trained Men and Women.
LID - 10.3390/jfmk8030088 [doi]
LID - 88
AB  - L-citrulline serves as a nitric oxide precursor with the potential to increase 
      blood flow and improve resistance exercise performance, yet more research is 
      needed to examine its ergogenic potential. To examine the effect of L-citrulline 
      supplementation on resistance exercise performance, muscle oxygenation, and the 
      subjective perception of effort, energy, focus, fatigue, and muscle pump, 
      eighteen resistance-trained men (n = 11) and women (n = 7) (21.4 +/- 1.8 years; 
      172.3 +/- 7.5 cm; 76.9 +/- 10.8 kg) were randomly assigned for supplementation with 8 
      g of L-citrulline (CIT) or a placebo (PL) in a cross-over fashion one hour prior 
      to testing. Participants completed an isometric mid-thigh pull test (IMTP), a 
      ballistic bench press protocol [two sets of two repetitions at 75% 1-repetition 
      maximum (1 RM) with maximum ballistic intent], and a strength-endurance bench 
      press protocol [five repetition-maximum sets at 75% 1RM]. Barbell velocity and 
      power were measured via a linear position transducer during the ballistic 
      protocol, while the repetitions completed, volume load and muscle oxygenation 
      were quantified during the strength-endurance protocol. Subjective measures were 
      assessed at the baseline and immediately pre- and post-exercise. Repeated 
      measures of the analysis of variance and Bayesian equivalents revealed no 
      significant interactions, providing evidence favoring the null hypothesis (BF10 < 
      1) for IMTP (PL 497.5 +/- 133.6 vs. CIT 492.5 +/- 129.4 N), barbell velocity, and 
      power, and repetitions completed (PL 36.7 +/- 7.2 vs. CIT 36.9 +/- 8.1 repetitions). 
      There were also no significant interactions for muscle oxygenation parameters or 
      subjective measures except perceived fatigue. Women reported greater fatigue 
      across all time points compared to men (~1.88 au, p = 0.045, BF10 = 0.2). The 
      results indicate that a single 8 g dose of L-citrulline did not enhance isometric 
      force production, muscle endurance, or muscle oxygenation parameters during the 
      protocol implemented in this study.
FAU - Gonzalez, Adam M
AU  - Gonzalez AM
AD  - Department of Allied Health and Kinesiology, Hofstra University, Hempstead, NY 
      11549, USA.
FAU - Yang, Yang
AU  - Yang Y
AUID- ORCID: 0009-0008-3231-7295
AD  - Department of Allied Health and Kinesiology, Hofstra University, Hempstead, NY 
      11549, USA.
FAU - Mangine, Gerald T
AU  - Mangine GT
AUID- ORCID: 0000-0003-2718-2564
AD  - Department of Exercise Science and Sport Management, Kennesaw State University, 
      Kennesaw, GA 30144, USA.
FAU - Pinzone, Anthony G
AU  - Pinzone AG
AUID- ORCID: 0009-0001-1381-0868
AD  - Program in Exercise Science and Exercise Physiology, Kent State University, Kent, 
      OH 44242, USA.
FAU - Ghigiarelli, Jamie J
AU  - Ghigiarelli JJ
AD  - Department of Allied Health and Kinesiology, Hofstra University, Hempstead, NY 
      11549, USA.
FAU - Sell, Katie M
AU  - Sell KM
AD  - Department of Allied Health and Kinesiology, Hofstra University, Hempstead, NY 
      11549, USA.
LA  - eng
PT  - Journal Article
DEP - 20230622
PL  - Switzerland
TA  - J Funct Morphol Kinesiol
JT  - Journal of functional morphology and kinesiology
JID - 101712257
PMC - PMC10366749
OTO - NOTNLM
OT  - arginine
OT  - citrulline malate
OT  - ergogenic aid
OT  - nitric oxide
OT  - resistance training
COIS- A.M.G. declares that he serves as a Scientific Advisor for Shifted LLC: a 
      manufacturer of sports supplements. All other authors report no conflict of 
      interest.
EDAT- 2023/07/25 06:43
MHDA- 2023/07/25 06:44
PMCR- 2023/06/22
CRDT- 2023/07/25 04:42
PHST- 2023/04/27 00:00 [received]
PHST- 2023/06/01 00:00 [revised]
PHST- 2023/06/19 00:00 [accepted]
PHST- 2023/07/25 06:44 [medline]
PHST- 2023/07/25 06:43 [pubmed]
PHST- 2023/07/25 04:42 [entrez]
PHST- 2023/06/22 00:00 [pmc-release]
AID - jfmk8030088 [pii]
AID - jfmk-08-00088 [pii]
AID - 10.3390/jfmk8030088 [doi]
PST - epublish
SO  - J Funct Morphol Kinesiol. 2023 Jun 22;8(3):88. doi: 10.3390/jfmk8030088.