PMID- 37489315
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230727
IS  - 2411-5142 (Electronic)
IS  - 2411-5142 (Linking)
VI  - 8
IP  - 3
DP  - 2023 Jul 24
TI  - Whole Body Substrate Metabolism during Different Exercise Intensities with 
      Special Emphasis on Blood Protein Changes in Trained Subjects-A Pilot Study.
LID - 10.3390/jfmk8030102 [doi]
LID - 102
AB  - Contrary to carbohydrate and fat metabolism, the influence of a single exercise 
      dose on protein metabolism has not been adequately explored yet. We assessed the 
      effects of different exercise intensities and durations on blood protein changes 
      and their association with carbohydrate (CHO) and fat metabolism in six eligible 
      trained subjects. Subjects performed maximal incremental (IE(100): at 
      100%VO(2max)) and submaximal continuous exercise (CE) at 75%VO(2max) for 30 min 
      (CE(75)) and at 50%VO(2max) for 90 min (CE(50)). Blood samples were collected at 
      rest (R), end of exercise (EE), and 1 h after recovery to assess blood urea 
      nitrogen (BUN), plasma amino acids (AA), glucose, lactate, FFA, and glycerol. In 
      IE(100) blood lactate, CHO-oxidation (g/min), energy expenditure (kcal/min), and 
      RER were significantly increased during rest (p < 0.05). CE(50) induced 
      significantly higher BUN, FFA, glycerol, and fat oxidation (g/min) (p < 0.05). At 
      recovery, the mean sum of the free AA pool (micromol/L) reduced by 8% (p < 0.03) 
      during CE(50). Values for CE(75) were between IE(100) and CE(50). Beside 
      lipolysis, also proteolysis (BUN) was an important source of fuel for 
      low-to-moderate intensity CE(50). An increased uptake of AA from the plasma bed 
      during CE(50) suggests the importance for oxidation and synthesis of other 
      metabolic sources such as gluconeogenesis necessary for recovery. Therefore, one 
      needs to be cautious of protein diet following prolonged cycle exercise training.
FAU - Mekonen, Wondyefraw
AU  - Mekonen W
AD  - Department of Physiology, College of Health Sciences, Tikur-Anbessa Medical 
      School, Addis Ababa University, P.O. Box 5657, Addis Ababa 1165, Ethiopia.
FAU - Schwaberger, Gunther
AU  - Schwaberger G
AD  - Institute of Physiology & Pathophysiology, Medical University Graz, Neue 
      Stiftingtalstrasse 6, 8010 Graz, Austria.
FAU - Lamprecht, Manfred
AU  - Lamprecht M
AD  - Institute of Nutrient Research, Petersbergenstrasse 95b, 8042 Graz, Austria.
AD  - Division of Medicinal Chemistry, Neue Stiftingtalstrasse 6, 8010 Graz, Austria.
FAU - Hofmann, Peter
AU  - Hofmann P
AUID- ORCID: 0000-0003-4836-1238
AD  - Institute of Human Movement Science, Sport and Health, Exercise Physiology, 
      Training Therapy Research Group, University of Graz, Aigner-Rollett-Allee 11, 
      8010 Graz, Austria.
LA  - eng
PT  - Journal Article
DEP - 20230724
PL  - Switzerland
TA  - J Funct Morphol Kinesiol
JT  - Journal of functional morphology and kinesiology
JID - 101712257
PMC - PMC10366854
OTO - NOTNLM
OT  - FFA
OT  - amino acids
OT  - exercise
OT  - glucose
OT  - glycerol
OT  - urea
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/25 06:43
MHDA- 2023/07/25 06:44
PMCR- 2023/07/24
CRDT- 2023/07/25 04:42
PHST- 2023/04/20 00:00 [received]
PHST- 2023/07/12 00:00 [revised]
PHST- 2023/07/20 00:00 [accepted]
PHST- 2023/07/25 06:44 [medline]
PHST- 2023/07/25 06:43 [pubmed]
PHST- 2023/07/25 04:42 [entrez]
PHST- 2023/07/24 00:00 [pmc-release]
AID - jfmk8030102 [pii]
AID - jfmk-08-00102 [pii]
AID - 10.3390/jfmk8030102 [doi]
PST - epublish
SO  - J Funct Morphol Kinesiol. 2023 Jul 24;8(3):102. doi: 10.3390/jfmk8030102.