PMID- 37489592
OWN - NLM
STAT- MEDLINE
DCOM- 20230726
LR  - 20230726
IS  - 1365-3083 (Electronic)
IS  - 0300-9475 (Linking)
VI  - 97
IP  - 5
DP  - 2023 May
TI  - Advances in understanding the role of dendritic cells in aplastic anaemia.
PG  - e13265
LID - 10.1111/sji.13265 [doi]
AB  - Aplastic anaemia (AA) is an autoimmune disease characterized by haematopoietic 
      failure in the bone marrow. Abnormal activation and hyperfunction of T 
      lymphocytes are believed to cause bone marrow damage, which plays a major role in 
      AA pathogenesis. Dendritic cells (DCs) play a vital role in the immune system by 
      processing antigens for presentation to T cells and regulating their 
      differentiation and function. DC dysfunction may cause abnormal T-cell 
      activation. Recent studies have associated the occurrence and development of AA 
      with DC function. In this review, we have discussed the role of DCs in AA 
      pathogenesis and their potential as putative therapeutic targets for AA.
CI  - (c) 2023 The Scandinavian Foundation for Immunology.
FAU - Gao, Mingjie
AU  - Gao M
AUID- ORCID: 0000-0002-0666-6036
AD  - Shandong University of Traditional Chinese Medicine, Jinan, China.
FAU - Zhang, Denglu
AU  - Zhang D
AD  - Central Laboratory, Affiliated Hospital of Shandong University of Traditional 
      Chinese Medicine, Jinan, China.
FAU - Xu, Ruirong
AU  - Xu R
AD  - Department of Hematology, Affiliated Hospital of Shandong University of 
      Traditional Chinese Medicine, Jinan, China.
AD  - Institute of Hematology, Shandong University of Traditional Chinese Medicine, 
      Jinan, China.
AD  - Shandong Provincial Health Commission Key Laboratory of Hematology of Integrated 
      Traditional Chinese and Western Medicine, Affiliated Hospital of Shandong 
      University of Traditional Chinese Medicine, Jinan, China.
LA  - eng
GR  - 82074171/National Natural Science Foundation of China/
GR  - ZR2020KH023/Natural Science Foundation of Shandong Province/
PT  - Journal Article
PT  - Review
DEP - 20230326
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
SB  - IM
MH  - Humans
MH  - *Anemia, Aplastic
MH  - *Autoimmune Diseases
MH  - Cell Differentiation
MH  - Dendritic Cells
OTO - NOTNLM
OT  - aplastic anaemia
OT  - autoimmunity
OT  - dendritic cells
OT  - immune tolerance
EDAT- 2023/07/25 13:09
MHDA- 2023/07/26 06:42
CRDT- 2023/07/25 06:40
PHST- 2023/02/12 00:00 [revised]
PHST- 2022/08/07 00:00 [received]
PHST- 2023/03/10 00:00 [accepted]
PHST- 2023/07/26 06:42 [medline]
PHST- 2023/07/25 13:09 [pubmed]
PHST- 2023/07/25 06:40 [entrez]
AID - 10.1111/sji.13265 [doi]
PST - ppublish
SO  - Scand J Immunol. 2023 May;97(5):e13265. doi: 10.1111/sji.13265. Epub 2023 Mar 26.