PMID- 37491112
OWN - NLM
STAT- MEDLINE
DCOM- 20230727
LR  - 20230727
IS  - 1879-3592 (Electronic)
IS  - 1383-5718 (Linking)
VI  - 889
DP  - 2023 Jul
TI  - Assessment of radiation doses and DNA damage in pediatric patients undergoing 
      interventional procedures for vascular anomalies.
PG  - 503653
LID - S1383-5718(23)00071-2 [pii]
LID - 10.1016/j.mrgentox.2023.503653 [doi]
AB  - Interventional procedures (IPs) have been widely used to treat vascular anomalies 
      (VA) in recent years. However, patients are exposed to low-dose X-ray ionizing 
      radiation (IR) during these fluoroscopy-guided IPs. We collected clinical 
      information and IR doses during IPs and measured biomarkers including gamma-H2AX, 
      chromosome aberrations (CA), and micronuclei (MN), which underpin 
      radiation-induced DNA damage, from 74 pediatric patients before and after IPs. 
      For the 74 children, the range of dose-area product (DAP) values was from 1.2 to 
      1754.6 Gy∙cm(2), with a median value of 27.1 Gy∙cm(2). DAP values were 
      significantly higher in children with lesions in the head and neck than in the 
      limbs and trunk; the age and weight of children revealed a strong positive 
      correlation with DAP values. The treated patients as a group demonstrated an 
      increase in all three endpoints relative to baseline following IPs. Children with 
      vascular tumors have a higher risk of dicentric chromosome + centric ring (dic+r) 
      and cytokinesis-block micronucleus (CBMN) after IPs than children with vascular 
      malformations. The younger the patient, the greater the risk of CA after IPs. 
      Moreover, rogue cells (RCs) were found in five children (approximately 10%) after 
      IPs, and the rates of dic+r and CBMN were significantly higher than those of 
      other children (Z = -3.576, p < 0.001). These results suggest that there may be 
      some children with VA who are particularly sensitive to IR, but more data and 
      more in-depth experiments will be needed to verify this in the future.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Ma, Ya
AU  - Ma Y
AD  - School of Preventive Medicine Sciences (Institute of Radiation Medicine), 
      Shandong First Medical University (Shandong Academy of Medical Sciences), No. 
      6699 Qingdao Road, Jinan 250117, PR China.
FAU - Guo, Lei
AU  - Guo L
AD  - Jinan Children's Hospital, No. 23976 Jingshi Road, Jinan 250022, PR China.
FAU - Fang, Lianying
AU  - Fang L
AD  - School of Preventive Medicine Sciences (Institute of Radiation Medicine), 
      Shandong First Medical University (Shandong Academy of Medical Sciences), No. 
      6699 Qingdao Road, Jinan 250117, PR China.
FAU - Hou, Dianjun
AU  - Hou D
AD  - School of Preventive Medicine Sciences (Institute of Radiation Medicine), 
      Shandong First Medical University (Shandong Academy of Medical Sciences), No. 
      6699 Qingdao Road, Jinan 250117, PR China.
FAU - Chen, Rui
AU  - Chen R
AD  - School of Preventive Medicine Sciences (Institute of Radiation Medicine), 
      Shandong First Medical University (Shandong Academy of Medical Sciences), No. 
      6699 Qingdao Road, Jinan 250117, PR China.
FAU - Wang, Xiaoshan
AU  - Wang X
AD  - School of Preventive Medicine Sciences (Institute of Radiation Medicine), 
      Shandong First Medical University (Shandong Academy of Medical Sciences), No. 
      6699 Qingdao Road, Jinan 250117, PR China.
FAU - Mao, Xuesong
AU  - Mao X
AD  - School of Preventive Medicine Sciences (Institute of Radiation Medicine), 
      Shandong First Medical University (Shandong Academy of Medical Sciences), No. 
      6699 Qingdao Road, Jinan 250117, PR China.
FAU - Zhao, Zihan
AU  - Zhao Z
AD  - High School Attached to Shandong Normal University, No. 3 Shanshi North Street, 
      Jinan 250014, PR China.
FAU - Chen, Yingmin
AU  - Chen Y
AD  - School of Preventive Medicine Sciences (Institute of Radiation Medicine), 
      Shandong First Medical University (Shandong Academy of Medical Sciences), No. 
      6699 Qingdao Road, Jinan 250117, PR China. Electronic address: 
      ymchen@sdfmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230624
PL  - Netherlands
TA  - Mutat Res Genet Toxicol Environ Mutagen
JT  - Mutation research. Genetic toxicology and environmental mutagenesis
JID - 101632149
SB  - IM
MH  - Humans
MH  - Child
MH  - *Chromosome Aberrations
MH  - Cell Nucleus
MH  - DNA Damage
MH  - *Vascular Malformations
MH  - Radiation Dosage
OTO - NOTNLM
OT  - Chromosomal aberrations
OT  - Interventional procedures
OT  - Low dose radiation effects
OT  - Micronuclei
OT  - Vascular anomalies
OT  - gamma-H2AX
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/07/26 01:06
MHDA- 2023/07/27 06:43
CRDT- 2023/07/25 20:53
PHST- 2022/12/16 00:00 [received]
PHST- 2023/06/07 00:00 [revised]
PHST- 2023/06/22 00:00 [accepted]
PHST- 2023/07/27 06:43 [medline]
PHST- 2023/07/26 01:06 [pubmed]
PHST- 2023/07/25 20:53 [entrez]
AID - S1383-5718(23)00071-2 [pii]
AID - 10.1016/j.mrgentox.2023.503653 [doi]
PST - ppublish
SO  - Mutat Res Genet Toxicol Environ Mutagen. 2023 Jul;889:503653. doi: 
      10.1016/j.mrgentox.2023.503653. Epub 2023 Jun 24.