PMID- 37491791
OWN - NLM
STAT- MEDLINE
DCOM- 20231116
LR  - 20231127
IS  - 2366-9608 (Electronic)
IS  - 2366-9608 (Linking)
VI  - 7
IP  - 11
DP  - 2023 Nov
TI  - Designing Selenium Nanoadjuvant as Universal Agent for Live-Killed Virus-Based 
      Vaccine.
PG  - e2300293
LID - 10.1002/smtd.202300293 [doi]
AB  - Inactivated virus vaccines with whole antigen spectra and good safety are the 
      commonly used modality for preventing infections. However, the poor 
      immunogenicity greatly limits its clinical applications. Herein, by taking 
      advantages of the crucial roles of Se in the functions of immune cells and its 
      biomineralization property, it successfully in-situ synthesized Se nanoadjuvant 
      on inactivated viruses such as porcine epidemic diarrhea virus (PEDV), 
      pseudorabies virus (PRV), and porcine reproductive and respiratory syndrome virus 
      (PRRSV) in a facile method, which is universal to construct other inactivated 
      virus vaccines. The nanovaccine can highly effectively enhance the uptake of 
      PEDV/PRV/PRRSV into dendritic cells (DCs) and activate DCs via triggering TLR4 
      signaling pathways and regulating selenoproteins expressions. Furthermore, it 
      exhibited better activities in triggering macrophages and natural killer 
      cells-mediated innate immunity and T cells-mediated cellular immunity compared to 
      PEDV and the commercial inactivated PEDV vaccine on both mice and swine models. 
      This study provides a universal Se nanoadjuvant for developing inactivated 
      viruses-based nanovaccines for preventing virus infections.
CI  - (c) 2023 Wiley-VCH GmbH.
FAU - Deng, Bo
AU  - Deng B
AD  - Department of Chemistry, Guangdong Provincial Key Laboratory of Functional 
      Supramolecular Coordination Materials and Applications, Jinan University, 
      Guangzhou, Guangdong, 510632, China.
FAU - He, Xiaoming
AU  - He X
AD  - Wens Foodstuff Group Co. Ltd, Yunfu, Guangdong, 527400, China.
FAU - Wang, Dongdong
AU  - Wang D
AD  - Wens Foodstuff Group Co. Ltd, Yunfu, Guangdong, 527400, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Chemistry, Guangdong Provincial Key Laboratory of Functional 
      Supramolecular Coordination Materials and Applications, Jinan University, 
      Guangzhou, Guangdong, 510632, China.
FAU - Jiang, Yalin
AU  - Jiang Y
AD  - Department of Chemistry, Guangdong Provincial Key Laboratory of Functional 
      Supramolecular Coordination Materials and Applications, Jinan University, 
      Guangzhou, Guangdong, 510632, China.
FAU - Chen, Tianfeng
AU  - Chen T
AUID- ORCID: 0000-0001-6953-1342
AD  - Department of Chemistry, Guangdong Provincial Key Laboratory of Functional 
      Supramolecular Coordination Materials and Applications, Jinan University, 
      Guangzhou, Guangdong, 510632, China.
FAU - Xu, Ligeng
AU  - Xu L
AUID- ORCID: 0000-0003-4946-2567
AD  - Department of Chemistry, Guangdong Provincial Key Laboratory of Functional 
      Supramolecular Coordination Materials and Applications, Jinan University, 
      Guangzhou, Guangdong, 510632, China.
LA  - eng
GR  - 32171296-T.C./Natural Science Foundation of China/
GR  - 82225025-T.C./National Science Fund for Distinguished Young Scholars/
GR  - 2019KZDXM029/Natural Science Major Project of Guangdong Province/
GR  - 2021B1515020018-L.X./Guangdong Basic and Applied Basic Research Foundation/
GR  - 2020B1515120043-T.C./Guangdong Basic and Applied Basic Research Foundation/
GR  - 2021B09-L.X./Open Fund of the Guangdong Provincial Key Laboratory of Functional 
      Supramolecular Coordination Materials and Applications/
GR  - JCYJ20200109142019319/Shenzhen Fundamental Research Program/
PT  - Journal Article
DEP - 20230725
PL  - Germany
TA  - Small Methods
JT  - Small methods
JID - 101724536
RN  - H6241UJ22B (Selenium)
RN  - 0 (Viral Vaccines)
RN  - 0 (Vaccines, Inactivated)
SB  - IM
MH  - Swine
MH  - Animals
MH  - Mice
MH  - *Selenium
MH  - *Swine Diseases/prevention & control
MH  - *Viral Vaccines
MH  - Vaccines, Inactivated
MH  - *Porcine Reproductive and Respiratory Syndrome
MH  - *Porcine respiratory and reproductive syndrome virus
OTO - NOTNLM
OT  - antigen delivery
OT  - nanoadjuvant
OT  - nanovaccines
OT  - virus infection
EDAT- 2023/07/26 06:42
MHDA- 2023/11/16 06:45
CRDT- 2023/07/26 01:04
PHST- 2023/06/01 00:00 [revised]
PHST- 2023/03/07 00:00 [received]
PHST- 2023/11/16 06:45 [medline]
PHST- 2023/07/26 06:42 [pubmed]
PHST- 2023/07/26 01:04 [entrez]
AID - 10.1002/smtd.202300293 [doi]
PST - ppublish
SO  - Small Methods. 2023 Nov;7(11):e2300293. doi: 10.1002/smtd.202300293. Epub 2023 
      Jul 25.