PMID- 37492546
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230727
IS  - 2038-9922 (Print)
IS  - 2038-9930 (Electronic)
IS  - 2038-9922 (Linking)
VI  - 14
IP  - Suppl 1
DP  - 2023 Mar 30
TI  - The dissolution of p-methoxycinnamic acid-beta-cyclodextrin inclusion complex 
      produced with microwave irradiation.
PG  - 2500
LID - 10.4081/jphia.2023.2500 [doi]
LID - 2500
AB  - BACKGROUND: p-methoxycinnamic acid (pMCA) is an ethyl pmethoxycinnamic 
      derivative, which is the largest active ingredient in the rhizome of the kencur 
      (Kaempferia galanga L) plant. Several studies reported that the compound has 
      anti-inflammatory activity but has low solubility in water. The formation of a 
      pMCA-beta- cyclodextrin (betaCD) inclusion complex with a molar ratio of 1:1 can 
      increase its solubility. The formation of inclusion complexes with conventional 
      methods requires a long time and the yield value is not optimal. OBJECTIVE: This 
      study aims to evaluate the dissolution of the pMCA-betaCD inclusion complex produced 
      using the microwave irradiation method. METHODS: The product was manufactured 
      with chloroform solvent and a power of 400 watts (power 80%). It was then 
      evaluated using the Differential Thermal Analysis (DTA) every 2 minutes until the 
      8th minute. The reaction was complete after 4 minutes of treatment with a yield 
      of 96.5%. The obtained inclusion complexes were evaluated using DTA, FTIR, and 
      PXRD. Subsequently, a dissolution test was carried out using a type 2 apparatus 
      in distilled water medium of pH 6.8+/-0.05 at 37+/-0.5 degrees C. RESULTS: The results showed 
      that there was a change in the melting temperature profile, infrared spectra, and 
      crystallinity of the product. An 89.18% dissolution was also obtained within 60 
      minutes, which was twice that of pMCA compounds. CONCLUSION: From the results of 
      the study, it can be concluded that the formation of pMCA-betaCD inclusion complexes 
      using the microwave irradiation method is capable of providing high-yield values 
      in a short time.
CI  - (c)Copyright: the Author(s).
FAU - Isadiartuti, Dewi
AU  - Isadiartuti D
AD  - Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas 
      Airlangga, Surabaya, Indonesia.
FAU - Ekowati, Juni
AU  - Ekowati J
AD  - Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas 
      Airlangga, Surabaya, Indonesia.
FAU - Noorma
AU  - Noorma
AD  - Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas 
      Airlangga, Surabaya, Indonesia.
FAU - Rosita
AU  - Rosita
AD  - Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas 
      Airlangga, Surabaya, Indonesia.
FAU - Amalia, Nabella Rizki
AU  - Amalia NR
AD  - Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas 
      Airlangga, Surabaya, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20230316
PL  - Italy
TA  - J Public Health Afr
JT  - Journal of public health in Africa
JID - 101586943
PMC - PMC10365669
OTO - NOTNLM
OT  - Dissolution
OT  - Drug
OT  - Microwave irradiation
OT  - p-methoxycinnamic acid
OT  - beta-cyclodextrin
COIS- Conflict of interest: The authors have no other relevant affiliations or 
      financial involvement with any organization or entity with a financial interest 
      in or financial conflict with the subject matter or materials discussed in the 
      manuscript apart from those disclosed.
EDAT- 2023/07/26 06:43
MHDA- 2023/07/26 06:44
PMCR- 2023/03/16
CRDT- 2023/07/26 03:53
PHST- 2022/10/26 00:00 [received]
PHST- 2022/12/30 00:00 [accepted]
PHST- 2023/07/26 06:44 [medline]
PHST- 2023/07/26 06:43 [pubmed]
PHST- 2023/07/26 03:53 [entrez]
PHST- 2023/03/16 00:00 [pmc-release]
AID - 10.4081/jphia.2023.2500 [doi]
PST - epublish
SO  - J Public Health Afr. 2023 Mar 16;14(Suppl 1):2500. doi: 10.4081/jphia.2023.2500. 
      eCollection 2023 Mar 30.