PMID- 3749300
OWN - NLM
STAT- MEDLINE
DCOM- 19861001
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 37
IP  - 3
DP  - 1986
TI  - Distinct substrates influence the acquisition of self-stimulation of the 
      hippocampus and the prefrontal cortex.
PG  - 409-18
AB  - Self-stimulation (SS) of both the medial prefrontal cortex (MPFC) and the 
      dorsolateral hippocampus (HPC) is known to develop slowly, over a period of days. 
      In both cases, the acquisition of bar-pressing can be markedly hastened by 
      delivery of noncontingent electrical stimulation for several days prior to SS 
      training. The similarity of these effects suggests that there might be a common 
      substrate mediating the acquisition process. However, in the present experiment, 
      pre-training noncontingent electrical stimulation of the MPFC had no effect on 
      how rapidly rats acquired the bar-pressing response for HPC stimulation, or vice 
      versa. A further dissociation of the elements governing the acquisition process 
      for these two SS sites was suggested by the observation that pre-training 
      noncontingent stimulation of the entorhinal cortex facilitated the speed of 
      acquisition of SS of the HPC but not of the MPFC. It seems that the HPC and 
      entorhinal cortex can be excluded from the subset of neural structures which are 
      known to influence the acquisition process governing MPFC SS. These and other 
      data suggest that the development of SS of the MPFC and HPC can be regarded, at 
      least in part, as involving a process rooted in distinct substrates.
FAU - Robertson, A
AU  - Robertson A
FAU - Laferriere, A
AU  - Laferriere A
FAU - Milner, P M
AU  - Milner PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
SB  - IM
MH  - Animals
MH  - Brain Mapping
MH  - Conditioning, Operant/physiology
MH  - Electric Stimulation
MH  - Frontal Lobe/*physiology
MH  - Hippocampus/*physiology
MH  - Limbic System/*physiology
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Self Stimulation/*physiology
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 0031-9384(86)90198-8 [pii]
AID - 10.1016/0031-9384(86)90198-8 [doi]
PST - ppublish
SO  - Physiol Behav. 1986;37(3):409-18. doi: 10.1016/0031-9384(86)90198-8.