PMID- 37496018
OWN - NLM
STAT- MEDLINE
DCOM- 20230728
LR  - 20230729
IS  - 1475-2891 (Electronic)
IS  - 1475-2891 (Linking)
VI  - 22
IP  - 1
DP  - 2023 Jul 26
TI  - Association of major dietary patterns with advanced glycation end products and 
      high-sensitivity C-reactive protein in people with type 1 diabetes mellitus.
PG  - 37
LID - 10.1186/s12937-023-00860-x [doi]
LID - 37
AB  - BACKGROUND: The associations of diet with serum levels of advanced glycation end 
      products (AGEs) and high-sensitivity C-reactive protein (hs-CRP) have been 
      examined in patients with type 2 diabetes mellitus (T2DM). However, data on 
      patients with type 1 diabetes mellitus (T1DM) are limited. Therefore, this study 
      was conducted to investigate the associations of major dietary patterns with 
      serum levels of AGEs and hs-CRP among patients with T1DM. METHODS: A total of 229 
      patients with T1DM participated in this current cross-sectional study. We 
      collected dietary data using a validated food frequency questionnaire (FFQ). The 
      factor analysis approach was used to determine major dietary patterns. A fasting 
      blood sample was collected from each participant to assess serum levels of AGEs 
      and hs-CRP. The associations of dietary patterns with elevated levels of AGEs and 
      hs-CRP were assessed using binary logistic regression. RESULTS: Patients with 
      T1DM in the highest tertile of a Western dietary pattern had 4.32 times higher 
      odds of having elevated AGEs than those in the lowest tertile (OR: 4.32, 95% CI: 
      1.86-10.05). Additionally, adherence to the Western diet was associated with 2.97 
      times greater odds of having elevated hs-CRP (> 3 mg/L) (OR: 2.97, 95% CI: 
      1.22-7.24) in these patients. Such positive associations were not observed for 
      unhealthy and traditional dietary patterns. Moreover, higher adherence to a 
      semi-healthy diet (characterized by high consumption of white meat, whole grains, 
      processed meat, and a low salt intake) was associated with 87% lower odds of 
      having elevated hs-CRP (OR: 0.13, 95% CI: 0.05-0.35). However, we found no 
      significant association between the semi-healthy diet and AGEs levels. 
      CONCLUSION: We found that adherence to a Western dietary pattern was associated 
      with elevated levels of AGEs/hs-CRP in patients with T1DM. Also, we discovered a 
      significant inverse association between adherence to a semi-healthy diet and 
      hs-CRP levels.
CI  - (c) 2023. The Author(s).
FAU - Ebrahimi, Zohreh
AU  - Ebrahimi Z
AD  - Department of Nutrition, School of Public Health, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Shojaeian, Zahra
AU  - Shojaeian Z
AD  - Department of Nutrition, School of Public Health, Iran University of Medical 
      Sciences, Tehran, Iran.
FAU - Amiri, Fatemehsadat
AU  - Amiri F
AD  - Department of Nutrition, School of Public Health, Iran University of Medical 
      Sciences, Tehran, Iran. f.amiri58@yahoo.com.
FAU - Esmaillzadeh, Ahmad
AU  - Esmaillzadeh A
AD  - Department of Community Nutrition, School of Nutritional Sciences & Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Sadeghi, Omid
AU  - Sadeghi O
AD  - Nutrition and Food Security Research Center, Department of Community Nutrition, 
      Student Research Committee, School of Nutrition and Food Science, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Esteghamati, Alireza
AU  - Esteghamati A
AD  - Endocrinology and Metabolism Research Center (EMRC), Internal Medicine 
      Department, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Jahed, Seyed Adel
AU  - Jahed SA
AD  - Gabric Diabetes Education Association, Tehran, Iran.
FAU - Sedaghat, Sara
AU  - Sedaghat S
AD  - Gabric Diabetes Education Association, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230726
PL  - England
TA  - Nutr J
JT  - Nutrition journal
JID - 101152213
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Glycation End Products, Advanced)
SB  - IM
MH  - Humans
MH  - C-Reactive Protein/metabolism
MH  - *Diabetes Mellitus, Type 1
MH  - *Diabetes Mellitus, Type 2
MH  - Cross-Sectional Studies
MH  - Diet
MH  - Diet, Western
MH  - Glycation End Products, Advanced
PMC - PMC10369805
OTO - NOTNLM
OT  - AGEs
OT  - Dietary pattern
OT  - Type 1 diabetes
OT  - hs-CRP
COIS- The authors declare no competing interests.
EDAT- 2023/07/27 01:09
MHDA- 2023/07/28 06:43
PMCR- 2023/07/26
CRDT- 2023/07/26 23:41
PHST- 2022/07/01 00:00 [received]
PHST- 2023/06/22 00:00 [accepted]
PHST- 2023/07/28 06:43 [medline]
PHST- 2023/07/27 01:09 [pubmed]
PHST- 2023/07/26 23:41 [entrez]
PHST- 2023/07/26 00:00 [pmc-release]
AID - 10.1186/s12937-023-00860-x [pii]
AID - 860 [pii]
AID - 10.1186/s12937-023-00860-x [doi]
PST - epublish
SO  - Nutr J. 2023 Jul 26;22(1):37. doi: 10.1186/s12937-023-00860-x.