PMID- 37496412
OWN - NLM
STAT- MEDLINE
DCOM- 20230728
LR  - 20230728
IS  - 1735-5249 (Electronic)
IS  - 1735-1502 (Linking)
VI  - 22
IP  - 2
DP  - 2023 Apr 30
TI  - Insights into Overlappings of Fibrosis and Cancer: Exploring the Tumor-related 
      Cardinal Genes in Idiopathic Pulmonary Fibrosis.
PG  - 190-199
LID - 10.18502/ijaai.v22i2.12680 [doi]
AB  - The pathogenesis of idiopathic pulmonary fibrosis (IPF) is quite similar to that 
      of cancer pathogenesis, and several pathways appear to be involved in both 
      disorders. The mammalian target of the rapamycin (mTOR) pathway harbors several 
      established oncogenes and tumor suppressors. The same signaling molecules and 
      growth factors, such as vascular endothelial growth factor (VEGF), contributing 
      to cancer development and progression play a part in fibroblast proliferation, 
      myofibroblast differentiation, and the production of extracellular matrix in IPF 
      development as well. The expression of candidate genes acting upstream and 
      downstream of mTORC1, as well as Vegf and low-density lipoprotein receptor 
      related protein 1(Lrp1), was assessed using specific primers and quantitative 
      polymerase chain reaction (qPCR) within the lung tissues of bleomycin 
      (BLM)-induced IPF mouse models. Lung fibrosis was evaluated by histological 
      examinations and hydroxyproline colorimetric assay. BLM-exposed mice developed 
      lung injuries characterized by inflammatory manifestations and fibrotic features, 
      along with higher levels of collagen and hydroxyproline. Gene expression analyses 
      indicated a significant elevation of regulatory associated protein of mTOR 
      (Raptor), Ras homolog enriched in brain (Rheb), S6 kinase 1, and Eukaryotic 
      translation initiation factor 4E-binding protein 1 (4Ebp1), as well as a 
      significant reduction of Vegfa, Tuberous sclerosis complex (Tsc2), and Lrp1; no 
      changes were observed in the Tsc1 mRNA level. Our findings support the elevation 
      of S6K1 and 4EBP1 in response to the TSC/RHEB/mTORC1 axis, which profoundly 
      encourages the development and establishment of IPF and cancer. In addition, this 
      study suggests a possible preventive role for VEGF-A and LRP1 in the development 
      of IPF.
FAU - Taherian, Marjan
AU  - Taherian M
AD  - Department of Immunology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran AND Immunology Research Center, Institute of Immunology 
      and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran. 
      marjan.taherian@gmail.com.
FAU - Bayati, Paria
AU  - Bayati P
AD  - Department of Immunology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran AND Immunology Research Center, Institute of Immunology 
      and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran. 
      bayatee.p@gmail.com.
FAU - Assarehzadegan, Mohammad-Ali
AU  - Assarehzadegan MA
AD  - Department of Immunology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran AND Immunology Research Center, Institute of Immunology 
      and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran. 
      assareh.ma@iums.ac.ir.
FAU - Soleimani, Mansoureh
AU  - Soleimani M
AD  - The Cellular and Molecular Research Center, Iran University of Medical Sciences, 
      Tehran, Iran. soleimani.m@iums.ac.ir.
FAU - Poormoghim, Hadi
AU  - Poormoghim H
AD  - Department of Immunology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran AND Immunology Research Center, Institute of Immunology 
      and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran. 
      hadipoormoghim@yahoo.com.
FAU - Mojtabavi, Nazanin
AU  - Mojtabavi N
AD  - Department of Immunology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran AND Immunology Research Center, Institute of Immunology 
      and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran. 
      MOJTABAVI.N@IUMS.AC.IR.
LA  - eng
PT  - Journal Article
DEP - 20230430
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - RMB44WO89X (Hydroxyproline)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - 0 (Carrier Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Vascular Endothelial Growth Factor A/metabolism
MH  - Hydroxyproline
MH  - *Neoplasms
MH  - Mechanistic Target of Rapamycin Complex 1/metabolism
MH  - Carrier Proteins
MH  - Transcription Factors
MH  - *Idiopathic Pulmonary Fibrosis/genetics
MH  - Fibrosis
MH  - Mammals/metabolism
OTO - NOTNLM
OT  - 4E-bp1
OT  - Cancer
OT  - Idiopathic pulmonary fibrosis
OT  - Lrp1
OT  - Rheb1
OT  - Rptor
OT  - S6k1
OT  - Tsc1
OT  - Tsc2
OT  - Vegf
OT  - mTOR
EDAT- 2023/07/27 06:43
MHDA- 2023/07/28 06:42
CRDT- 2023/07/27 02:55
PHST- 2022/09/26 00:00 [received]
PHST- 2023/01/03 00:00 [accepted]
PHST- 2023/07/28 06:42 [medline]
PHST- 2023/07/27 06:43 [pubmed]
PHST- 2023/07/27 02:55 [entrez]
AID - 10.18502/ijaai.v22i2.12680 [doi]
PST - epublish
SO  - Iran J Allergy Asthma Immunol. 2023 Apr 30;22(2):190-199. doi: 
      10.18502/ijaai.v22i2.12680.