PMID- 37497112
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230728
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 14
DP  - 2023
TI  - Polysaccharides from natural resource: ameliorate type 2 diabetes mellitus via 
      regulation of oxidative stress network.
PG  - 1184572
LID - 10.3389/fphar.2023.1184572 [doi]
LID - 1184572
AB  - Diabetes mellitus (DM) is a group of metabolic diseases characterized by 
      hyperglycemia that can occur in children, adults, elderly people, and pregnant 
      women. Oxidative stress is a significant adverse factor in the pathogenesis of 
      DM, especially type 2 diabetes mellitus (T2DM), and metabolic syndrome. Natural 
      polysaccharides are macromolecular compounds widely distributed in nature. Some 
      polysaccharides derived from edible plants and microorganisms were reported as 
      early as 10 years ago. However, the structural characterization of 
      polysaccharides and their therapeutic mechanisms in diabetes are relatively 
      shallow, limiting the application of polysaccharides. With further research, more 
      natural polysaccharides have been reported to have antioxidant activity and 
      therapeutic effects in diabetes, including plant polysaccharides, microbial 
      polysaccharides, and polysaccharides from marine organisms and animals. 
      Therefore, this paper summarizes the natural polysaccharides that have 
      therapeutic potential for diabetes in the past 5 years, elucidating their 
      pharmacological mechanisms and identified primary structures. It is expected to 
      provide some reference for the application of polysaccharides, and provide a 
      valuable resource for the development of new diabetic drugs.
CI  - Copyright (c) 2023 He, Li, Niu, Bai, Liu and Guo.
FAU - He, Li-Ying
AU  - He LY
AD  - Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, 
      College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      China.
FAU - Li, Yong
AU  - Li Y
AD  - Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, 
      College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      China.
FAU - Niu, Shu-Qi
AU  - Niu SQ
AD  - College of Medical Technology, Chengdu University of Traditional Chinese 
      Medicine, Chengdu, China.
AD  - Chongqing Key Laboratory of Sichuan-Chongqing Co Construction for Diagnosis and 
      Treatment of Infectious Diseases Integrated Traditional Chinese and Western 
      Medicine, Chongqing, China.
FAU - Bai, Jing
AU  - Bai J
AD  - College of Medical Technology, Chengdu University of Traditional Chinese 
      Medicine, Chengdu, China.
FAU - Liu, Si-Jing
AU  - Liu SJ
AD  - College of Medical Technology, Chengdu University of Traditional Chinese 
      Medicine, Chengdu, China.
AD  - Chongqing Key Laboratory of Sichuan-Chongqing Co Construction for Diagnosis and 
      Treatment of Infectious Diseases Integrated Traditional Chinese and Western 
      Medicine, Chongqing, China.
FAU - Guo, Jin-Lin
AU  - Guo JL
AD  - Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, 
      College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 
      China.
AD  - College of Medical Technology, Chengdu University of Traditional Chinese 
      Medicine, Chengdu, China.
AD  - Chongqing Key Laboratory of Sichuan-Chongqing Co Construction for Diagnosis and 
      Treatment of Infectious Diseases Integrated Traditional Chinese and Western 
      Medicine, Chongqing, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230711
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC10367013
OTO - NOTNLM
OT  - diabetes mellitus
OT  - mechanism
OT  - metabolism
OT  - natural polysaccharide
OT  - oxidative stress
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/07/27 06:43
MHDA- 2023/07/27 06:44
PMCR- 2023/07/11
CRDT- 2023/07/27 04:21
PHST- 2023/03/12 00:00 [received]
PHST- 2023/07/04 00:00 [accepted]
PHST- 2023/07/27 06:44 [medline]
PHST- 2023/07/27 06:43 [pubmed]
PHST- 2023/07/27 04:21 [entrez]
PHST- 2023/07/11 00:00 [pmc-release]
AID - 1184572 [pii]
AID - 10.3389/fphar.2023.1184572 [doi]
PST - epublish
SO  - Front Pharmacol. 2023 Jul 11;14:1184572. doi: 10.3389/fphar.2023.1184572. 
      eCollection 2023.