PMID- 37498101
OWN - NLM
STAT- MEDLINE
DCOM- 20230803
LR  - 20240317
IS  - 1760-4788 (Electronic)
IS  - 1279-7707 (Linking)
VI  - 27
IP  - 7
DP  - 2023
TI  - Association between Intrinsic Capacity and Sarcopenia in Hospitalized Older 
      Patients.
PG  - 542-549
LID - 10.1007/s12603-023-1946-5 [doi]
AB  - OBJECTIVES: This study aimed to clarify the association between intrinsic 
      capacity (IC) and sarcopenia in hospitalized older patients. DESIGN: A 
      cross-sectional study. SETTING: Hospital-based. PARTICIPANTS: This study included 
      381 inpatients aged >/= 60 years (225 men and 156 women). MEASUREMENTS: IC was 
      evaluated in five domains defined by the World Health Organization: cognition 
      (Mini-Mental State Examination), locomotion (Short Physical Performance Battery 
      test), vitality (Short-Form Mini Nutritional Assessment), sensory (self-reported 
      hearing and vision) and psychological (5-item Geriatric Depression Scale) 
      capacities. IC composite score (0-5) was calculated based on five domains, with 
      lower scores representing greater IC. Sarcopenia was defined in accordance with 
      the criteria recommended by the Asian Working Group for Sarcopenia (AWGS) 2019. 
      Multiple linear and logistic regressions were performed to explore the 
      associations between IC composite score and IC domains with sarcopenia and its 
      defining components. RESULTS: The mean age of 381 patients included was 
      81.95+/-8.42 years. Of them, 128 (33.6%) patients had sarcopenia. The median IC 
      composite score was 1 (1, 2). Cognition, locomotion, vitality, sensory and 
      psychological capacities were impaired in 22.6%, 63.5%, 18.9%, 27.3% and 11.3% of 
      patients. Multiple linear regression analyses showed that favorable IC domain 
      scores in cognition, locomotion and vitality were associated with a stronger 
      handgrip strength. A higher vitality score was associated with a greater 
      appendicular skeletal muscle mass index (ASMI), and a higher locomotion score was 
      associated with a greater gait speed. The multiple logistic regression analysis 
      showed that only vitality impairment was associated with sarcopenia. A higher IC 
      composite score was associated with higher risks of sarcopenia, as well as low 
      ASMI, handgrip strength and gait speed. CONCLUSION: This study indicated that a 
      more serious impairment of IC was associated with a greater risk of sarcopenia. 
      Vitality was the domain most strongly associated with sarcopenia. IC may be 
      employed to detect and manage sarcopenia.
FAU - Zhu, L
AU  - Zhu L
AD  - Xiaojun Ouyang, Department of Geriatrics, Geriatric Hospital of Nanjing Medical 
      University, Nanjing, China, E-mail: xiaojun_ouyang@aliyun.com.
FAU - Zong, X
AU  - Zong X
FAU - Shi, X
AU  - Shi X
FAU - Ouyang, X
AU  - Ouyang X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - Aged
MH  - Cross-Sectional Studies
MH  - *Sarcopenia
MH  - Geriatric Assessment
MH  - Cognition
MH  - *Hand Strength/physiology
MH  - Hospitalization
MH  - Aged, 80 and over
MH  - Middle Aged
MH  - Gait
MH  - Walking Speed
OTO - NOTNLM
OT  - Intrinsic capacity
OT  - older adults
OT  - sarcopenia
COIS- None declared.
EDAT- 2023/07/27 13:10
MHDA- 2023/07/28 06:42
CRDT- 2023/07/27 09:13
PHST- 2023/07/28 06:42 [medline]
PHST- 2023/07/27 13:10 [pubmed]
PHST- 2023/07/27 09:13 [entrez]
AID - S1279-7707(23)00256-7 [pii]
AID - 10.1007/s12603-023-1946-5 [doi]
PST - ppublish
SO  - J Nutr Health Aging. 2023;27(7):542-549. doi: 10.1007/s12603-023-1946-5.