PMID- 37498425
OWN - NLM
STAT- MEDLINE
DCOM- 20230825
LR  - 20240327
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 30
IP  - 40
DP  - 2023 Aug
TI  - Combined exposure to multiple metals on hypertension in NHANES under four 
      statistical models.
PG  - 92937-92949
LID - 10.1007/s11356-023-28902-1 [doi]
AB  - Metals exposure has gained increasing attention in the hypertension prevention. 
      However, previous studies have focused on the impacts of single or separated 
      metals on hypertension, and the critical metals contributing to the prevalence of 
      hypertension are still under discussion. We collected data from 5092 participants 
      across three consecutive National Health and Nutrition Examination Survey 
      (NHANES) circles (2011-2016). Weighted logistic regression, weighted quantile sum 
      (WQS) regression, quantile-based g-computation (QGC), and Bayesian kernel machine 
      regression (BKMR) analyses were conducted to evaluate the combined and individual 
      effects of 15 urinary metals, as well as to identify the critical metals on the 
      development of hypertension. In our study, the weighted prevalence of 
      hypertension was 37.9%, and the average age was 47.42 years. Manganese, uranium 
      and tin were found as the independent risk factors for hypertension, while 
      barium, lead, and thallium were found to have protective effects against 
      hypertension. Lead, barium, tungsten, uranium, and tin were determined as 
      critical elements for the prediction of hypertension. No significant interaction 
      relationship was detected between multiple metals. There might be potential 
      positive combined effects of urinary metal mixture on hypertension. Tungsten, 
      uranium, and tin were positively associated with hypertension while lead and 
      barium were negatively associated with hypertension. The underlying mechanisms of 
      urinary metal exposure on the risk of hypertension deserve further 
      investigations.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Zhao, Songfeng
AU  - Zhao S
AD  - Department of Neurosurgery, the Third Xiangya Hospital, Central South University, 
      Hunan, China.
FAU - Fan, Liqiaona
AU  - Fan L
AD  - Department of General Medicine, Beijing Tsinghua Changgung Hospital, School of 
      Clinical Medicine, Tsinghua University, Beijing, China.
FAU - Wang, Yutong
AU  - Wang Y
AD  - Department of Neurosurgery, the Third Xiangya Hospital, Central South University, 
      Hunan, China.
FAU - Dong, Siyuan
AU  - Dong S
AD  - Department of Neurosurgery, the Third Xiangya Hospital, Central South University, 
      Hunan, China.
FAU - Han, Mingyang
AU  - Han M
AD  - Department of Neurosurgery, the Third Xiangya Hospital, Central South University, 
      Hunan, China.
FAU - Qin, Yongkai
AU  - Qin Y
AD  - Department of Neurosurgery, the Third Xiangya Hospital, Central South University, 
      Hunan, China.
FAU - Chen, Jigang
AU  - Chen J
AD  - Department of Burn and Plastic Surgery, National Center for Children's Health, 
      Beijing Children's Hospital, Capital Medical University, Beijing, China.
FAU - Liu, Aihua
AU  - Liu A
AUID- ORCID: 0000-0002-6391-805X
AD  - Department of Neurosurgery, the Third Xiangya Hospital, Central South University, 
      Hunan, China. liuaihuadoctor@163.com.
AD  - Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical 
      University, Beijing, 100070, China. liuaihuadoctor@163.com.
LA  - eng
GR  - 81771233，82171290/Natural Science Foundation of China/
GR  - GN-2020R0007/Research and Promotion Program of Appropriate Techniques for 
      Intervention of Chinese High-risk Stroke People/
GR  - Z181100009618035/BTH Coordinated Development- Beijing Science and Technology 
      Planning Project/
GR  - DFL20190501/Beijing Municipal Administration of Hospitals' Ascent Plan/
GR  - 19L2013/Beijing Natural Science Foundation/
GR  - 22G10396/Beijing Natural Science Foundation/
PT  - Journal Article
DEP - 20230727
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 24GP945V5T (Barium)
RN  - V9306CXO6G (Tungsten)
RN  - 4OC371KSTK (Uranium)
RN  - 7440-31-5 (Tin)
SB  - IM
MH  - Humans
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Environmental Exposure/analysis
MH  - Barium
MH  - Tungsten
MH  - *Uranium
MH  - Bayes Theorem
MH  - Tin
MH  - Models, Statistical
MH  - *Hypertension/chemically induced/epidemiology
OTO - NOTNLM
OT  - Bayesian kernel machine regression (BKMR)
OT  - Metals
OT  - National Health and Nutrition Examination Survey (NHANES)
OT  - Quantile-based g-computation (QGC)
OT  - Restricted cubic splines (RCS)
OT  - Weighted quantile sum (WQS)
EDAT- 2023/07/27 13:10
MHDA- 2023/08/25 06:42
CRDT- 2023/07/27 11:09
PHST- 2023/03/01 00:00 [received]
PHST- 2023/07/17 00:00 [accepted]
PHST- 2023/08/25 06:42 [medline]
PHST- 2023/07/27 13:10 [pubmed]
PHST- 2023/07/27 11:09 [entrez]
AID - 10.1007/s11356-023-28902-1 [pii]
AID - 10.1007/s11356-023-28902-1 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2023 Aug;30(40):92937-92949. doi: 
      10.1007/s11356-023-28902-1. Epub 2023 Jul 27.