PMID- 37498817
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230801
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 18
IP  - 7
DP  - 2023
TI  - Prescription of oral antidiabetics in Mexico. A cross-sectional study.
PG  - e0288699
LID - 10.1371/journal.pone.0288699 [doi]
LID - e0288699
AB  - In 2016 diabetes was declared an epidemic and a health emergency in Mexico. As 
      the rationale of the treatment is to achieve target glycemia levels, the 
      appropriateness of the medications used is important. The aim of this study is to 
      learn the pattern of antidiabetic drug prescription and factors associated with 
      inappropriate prescription in Mexico. A retrospective cross-sectional drug 
      utilization study has been conducted. A randomly selected sample was carefully 
      examined. Out of 3600 clinical records of patients diagnosed with type 2 diabetes 
      mellitus (T2DM), 196 records were revised. As far as control is concerned, 36.7% 
      had their glycemia values in the recommended range. A combination of different 
      antidiabetics was the most common pattern observed (60.7%); the most frequent was 
      that of the association of metformin with whatever oral antidiabetics. 
      Prescriptions were considered as inappropriate in 149 cases (76.0%); younger age 
      and lack of nutritional assessment was significantly related to inappropriate 
      prescription. A trend to use more drugs for treating T2DM has been consistently 
      observed. Despite using so many drugs, most of the patients are not controlled. 
      Avoiding inappropriate prescription by following current guidelines may 
      contribute to a better control and, in turn, decrease morbidity and mortality for 
      this cause.
CI  - Copyright: (c) 2023 Fierro et al. This is an open access article distributed under 
      the terms of the Creative Commons Attribution License, which permits unrestricted 
      use, distribution, and reproduction in any medium, provided the original author 
      and source are credited.
FAU - Fierro, Inmaculada
AU  - Fierro I
AUID- ORCID: 0000-0003-4423-4493
AD  - Departamento de Ciencias de la Salud, Universidad Europea Miguel de Cervantes, 
      Valladolid, Spain.
FAU - Gallardo-Mora, Osiel
AU  - Gallardo-Mora O
AD  - Programa de Maestria y Doctorado en Ciencias Medicas, Odontologicas y de la 
      Salud, Universidad Nacional Autonoma de Mexico (UNAM), Mexico, Mexico.
FAU - Alba-Leonel, Adela
AU  - Alba-Leonel A
AD  - Escuela Nacional de Enfermeria y Obstetricia, Universidad Nacional Autonoma de 
      Mexico (UNAM), Mexico, Mexico.
FAU - Carvajal, Alfonso
AU  - Carvajal A
AD  - Universidad de Valladolid, Valladolid, Spain.
FAU - Molina-Guarneros, Juan Arcadio
AU  - Molina-Guarneros JA
AD  - Departamento de Farmacologia, Facultad de Medicina, Universidad Nacional Autonoma 
      de Mexico (UNAM), Mexico, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20230727
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Humans
MH  - *Hypoglycemic Agents/therapeutic use
MH  - *Diabetes Mellitus, Type 2/drug therapy/epidemiology/complications
MH  - Cross-Sectional Studies
MH  - Retrospective Studies
MH  - Mexico/epidemiology
MH  - Drug Prescriptions
PMC - PMC10373993
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/07/27 19:10
MHDA- 2023/07/31 06:43
PMCR- 2023/07/27
CRDT- 2023/07/27 13:33
PHST- 2023/02/04 00:00 [received]
PHST- 2023/07/03 00:00 [accepted]
PHST- 2023/07/31 06:43 [medline]
PHST- 2023/07/27 19:10 [pubmed]
PHST- 2023/07/27 13:33 [entrez]
PHST- 2023/07/27 00:00 [pmc-release]
AID - PONE-D-23-03248 [pii]
AID - 10.1371/journal.pone.0288699 [doi]
PST - epublish
SO  - PLoS One. 2023 Jul 27;18(7):e0288699. doi: 10.1371/journal.pone.0288699. 
      eCollection 2023.