PMID- 37498994
OWN - NLM
STAT- MEDLINE
DCOM- 20240208
LR  - 20240208
IS  - 2169-5202 (Electronic)
IS  - 1550-0594 (Linking)
VI  - 55
IP  - 2
DP  - 2024 Mar
TI  - Ictal EEG: Etiology and Mortality in Older Adults With Nonconvulsive Status 
      Epilepticus.
PG  - 278-282
LID - 10.1177/15500594231183554 [doi]
AB  - Clinical-electroencephalogram (EEG), as well as etiological and prognostic data 
      on subtypes of nonconvulsive status epilepticus (NCSE) are yet to be established. 
      Objective: Evaluate the clinical semiology and EEG findings and prognostic data 
      of older adults with NCSE. Methodology: Characterize the clinical-EEG and 
      prognostic data in the subtypes of NCSE in older adults consecutively admitted to 
      the emergency room of the Pontificia Universidade Catolica de Campinas 
      (PUC-Campinas) University Hospital. Results: When evaluating 105 older adults 
      with altered consciousness, it was possible to diagnose NCSE in 50 (47.6%) older 
      adults, with a mean age of 72.8 +/- 8.8 years. NCSE-coma occurred in 6 cases, with 
      NCSE-without coma in 44 cases. The etiology was structural in 41(82%) cases, 
      metabolic in 5 cases, and unknown etiology in 4 cases. Twelve cases had a history 
      of epileptic seizures. On the EEG, epileptiform discharges (EDs > 2.5 Hz) were 
      present in 34(68%) cases and rhythmic delta activity /lateralized periodic 
      patterns occurred in 35(70%) cases. There was clinical improvement after the 
      initial pharmacological treatment in 36 cases and, within 30 days, 18 cases died. 
      The better prognosis was associated with a good response to initial 
      pharmacological treatment (n = 14) and with EDs > 2.5 Hz on EEG (Fisher's exact 
      test; 26 vs 8; P = .012). Conclusion: Focal NCSE with impaired consciousness was 
      the most frequent subtype. The most frequent finding on the EEG was the recording 
      of focal/regional seizures. A high number of cases showed initial clinical 
      improvement, but mortality was high. The favorable prognosis was associated with 
      initial clinical improvement and the presence of EDs > 2.5 Hz. There was no 
      relationship between EEG patterns and the etiology and subtypes of NCSE in older 
      adults.
FAU - Tedrus, Gloria M A S
AU  - Tedrus GMAS
AUID- ORCID: 0000-0002-3994-2113
AD  - Postgraduate Program in Health Sciences, Pontificia Universidade Catolica de 
      Campinas, Campinas, SP, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20230727
PL  - United States
TA  - Clin EEG Neurosci
JT  - Clinical EEG and neuroscience
JID - 101213033
SB  - IM
MH  - Humans
MH  - Aged
MH  - Middle Aged
MH  - Aged, 80 and over
MH  - Electroencephalography/adverse effects
MH  - Coma/diagnosis
MH  - *Status Epilepticus/diagnosis
MH  - Seizures/complications
MH  - *Epilepsy/complications
OTO - NOTNLM
OT  - EEG
OT  - nonconvulsive status epilepticus
OT  - older adults
COIS- Declaration of Conflicting InterestsThe author declared no potential conflicts of 
      interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2023/07/27 19:10
MHDA- 2024/02/08 06:42
CRDT- 2023/07/27 14:03
PHST- 2024/02/08 06:42 [medline]
PHST- 2023/07/27 19:10 [pubmed]
PHST- 2023/07/27 14:03 [entrez]
AID - 10.1177/15500594231183554 [doi]
PST - ppublish
SO  - Clin EEG Neurosci. 2024 Mar;55(2):278-282. doi: 10.1177/15500594231183554. Epub 
      2023 Jul 27.