PMID- 37499391 OWN - NLM STAT- MEDLINE DCOM- 20230929 LR - 20230929 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 263 DP - 2023 Sep 15 TI - The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people. PG - 115289 LID - S0147-6513(23)00793-5 [pii] LID - 10.1016/j.ecoenv.2023.115289 [doi] AB - BACKGROUND: Epidemiological studies about the effect of essential metal mixture on fasting plasma glucose (FPG) levels among elderly people are sparse. The object of this study was to examine the associations of single essential metals and essential metal mixture with FPG levels in Chinese community-dwelling elderly people. METHODS: The study recruited 2348 community-dwelling elderly people in total. Inductively coupled plasma-mass spectrometry was adopted to detect the levels of vanadium (V), selenium (Se), magnesium (Mg), cobalt (Co), calcium (Ca), and molybdenum (Mo) in urine. The relationships between single essential metals and essential metal mixture and FPG levels were evaluated by linear regression and Bayesian kernel machine regression (BKMR) models, respectively. RESULTS: In multiple-metal linear regression models, urine V and Mg were negatively related to the FPG levels (beta = - 0.016, 95 % CI: - 0.030 to - 0.003 for V; beta = - 0.021, 95 % CI: - 0.033 to - 0.009 for Mg), and urine Se was positively related to the FPG levels (beta = 0.024, 95 % CI: 0.014-0.034). In BKMR model, the significant relationships of Se and Mg with the FPG levels were also found. The essential metal mixture was negatively associated with FPG levels in a dose-response pattern, and Mg had the maximum posterior inclusion probability (PIP) value (PIP = 1.0000), followed by Se (PIP = 0.9968). Besides, Co showed a significant association with decreased FPG levels in older adults without hyperlipemia and in women. CONCLUSIONS: Both Mg and Se were associated with FPG levels, individually and as a mixture. The essential metal mixture displayed a linear dose-response relationship with reduced FPG levels, with Mg having the largest contribution to FPG levels, followed by Se. Further prospective investigations are necessary to validate these exploratory findings. CI - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Wang, Pan-Pan AU - Wang PP AD - School of Public Health, Department of Health Inspection and Quarantine, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Lei, Jing-Yuan AU - Lei JY AD - School of Public Health, Department of Health Inspection and Quarantine, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Wang, Yuan AU - Wang Y AD - School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Wang, Hong-Li AU - Wang HL AD - School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Sun, Liang AU - Sun L AD - Fuyang Center for Diseases Prevention and Control, Fuyang 236069, Anhui, China. FAU - Hu, Bing AU - Hu B AD - Fuyang Center for Diseases Prevention and Control, Fuyang 236069, Anhui, China. FAU - Wang, Su-Fang AU - Wang SF AD - School of Public Health, Department of Nutrition and Food Hygiene, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Zhang, Dong-Mei AU - Zhang DM AD - School of Health Services Management, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Chen, Gui-Mei AU - Chen GM AD - School of Health Services Management, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Liang, Chun-Mei AU - Liang CM AD - School of Public Health, Department of Health Inspection and Quarantine, Anhui Medical University, Hefei 230032, Anhui, China. FAU - Tao, Fang-Biao AU - Tao FB AD - MOE Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), No. 81 Meishan Road, Hefei 230032, Anhui, China. FAU - Yang, Lin-Sheng AU - Yang LS AD - School of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei 230032, Anhui, China. Electronic address: yanglinsheng@ahmu.edu.cn. FAU - Wu, Qing-Si AU - Wu QS AD - Department of Blood Transfusion, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui, China. Electronic address: wuqingsi@ahmu.edu.cn. LA - eng PT - Journal Article DEP - 20230725 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 RN - 0 (Blood Glucose) RN - 3G0H8C9362 (Cobalt) RN - H6241UJ22B (Selenium) RN - 00J9J9XKDE (Vanadium) RN - SY7Q814VUP (Calcium) RN - I38ZP9992A (Magnesium) RN - 81AH48963U (Molybdenum) RN - 0 (Metals) RN - 0 (Complex Mixtures) SB - IM MH - Aged MH - Female MH - Humans MH - Bayes Theorem MH - *Blood Glucose/analysis MH - Cobalt/urine MH - East Asian People MH - *Fasting/blood/urine MH - Independent Living MH - *Selenium/urine MH - Vanadium/urine MH - Mass Spectrometry MH - Calcium/urine MH - Magnesium/urine MH - Molybdenum/urine MH - *Metals/urine MH - Complex Mixtures/urine OTO - NOTNLM OT - Bayesian kernel machine regression OT - Elderly people OT - Essential metal mixture OT - Fasting blood glucose COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper. EDAT- 2023/07/28 01:08 MHDA- 2023/09/20 06:42 CRDT- 2023/07/27 18:04 PHST- 2023/05/01 00:00 [received] PHST- 2023/07/17 00:00 [revised] PHST- 2023/07/19 00:00 [accepted] PHST- 2023/09/20 06:42 [medline] PHST- 2023/07/28 01:08 [pubmed] PHST- 2023/07/27 18:04 [entrez] AID - S0147-6513(23)00793-5 [pii] AID - 10.1016/j.ecoenv.2023.115289 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2023 Sep 15;263:115289. doi: 10.1016/j.ecoenv.2023.115289. Epub 2023 Jul 25.