PMID- 37499807 OWN - NLM STAT- MEDLINE DCOM- 20230824 LR - 20230824 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 339 DP - 2023 Oct TI - Environmental exposure to paraben and its association with blood pressure: A cross-sectional study in China. PG - 139656 LID - S0045-6535(23)01923-9 [pii] LID - 10.1016/j.chemosphere.2023.139656 [doi] AB - Parabens (PBs) are the most widely used preservatives. Recent epidemiological studies have indicated that environmental exposure to parabens has adverse health effects, such as increased metabolic diseases risk. However, limited information is available on the cardiovascular effect of paraben exposure. Hence, we conducted a cross-sectional study investigating the associations between exposure to parabens with high blood pressure risk and blood pressure levels among the general Chinese population. In this study, we enrolled 1405 individuals from a medical center in Wuhan, China. Urinary methylparaben (MeP), ethylparaben (EtP), propylparaben (PrP) and butylparaben (BuP) concentrations were determined. Multivariable logistic and linear regression models were applied to analyze the associations between urinary parabens and high blood pressure risk and blood pressure level changes. Bayesian kernel machine regression (BKMR) models were applied to estimate the combined effect of the four parabens. Compared with the first quartile group, participants with the fourth quartile of EtP, PrP, and summation operatorparabens ( summation operatorPBs) concentrations had a 2.10-fold (95% CI: 1.40, 3.00), 1.83-fold (95% CI: 1.27, 2.62) and 1.84-fold (95% CI: 1.27, 2.65) increased the risk of hypertension, respectively. High urinary EtP, PrP, and summation operatorPBs levels were found to increase the levels of systolic and diastolic blood pressure (SBP and DBP), mean arterial pressure (MAP), and mid-blood pressure (MBP). BKMR models indicated the overall effects of the paraben mixture were significantly associated with high blood pressure risk and blood pressure level changes. Furthermore, after stratification by sex, the associations of EtP exposure and blood pressure levels were more pronounced in males. Our results suggest that environmental exposure to parabens might elevate blood pressure levels and increase the risk of high blood pressure. CI - Copyright (c) 2023 Elsevier Ltd. All rights reserved. FAU - Zhang, Xu AU - Zhang X AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Zhang, Ying AU - Zhang Y AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Lu, Hao AU - Lu H AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Yu, Fan AU - Yu F AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Shi, Xueting AU - Shi X AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Ma, Bingchan AU - Ma B AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Zhou, Shuang AU - Zhou S AD - Hubei Provincial Hospital of Traditional Chinese & Western Medicine, #11 Lingjiaohu Road, Wuhan, Hubei, 430015, China. Electronic address: 1105161481@qq.com. FAU - Wang, Lin AU - Wang L AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Lu, Qing AU - Lu Q AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. Electronic address: qi_weiliao@126.com. LA - eng PT - Journal Article DEP - 20230725 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 14255EXE39 (ethyl-p-hydroxybenzoate) RN - Z8IX2SC1OH (propylparaben) RN - 0 (Parabens) SB - IM MH - Male MH - Humans MH - *Parabens/analysis MH - Cross-Sectional Studies MH - Blood Pressure MH - Bayes Theorem MH - Environmental Exposure/analysis MH - China/epidemiology MH - *Hypertension/chemically induced/epidemiology OTO - NOTNLM OT - Blood pressure OT - Environmental exposure OT - Epidemiology OT - Parabens COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper EDAT- 2023/07/28 01:08 MHDA- 2023/08/24 06:42 CRDT- 2023/07/27 19:14 PHST- 2023/03/01 00:00 [received] PHST- 2023/07/13 00:00 [revised] PHST- 2023/07/24 00:00 [accepted] PHST- 2023/08/24 06:42 [medline] PHST- 2023/07/28 01:08 [pubmed] PHST- 2023/07/27 19:14 [entrez] AID - S0045-6535(23)01923-9 [pii] AID - 10.1016/j.chemosphere.2023.139656 [doi] PST - ppublish SO - Chemosphere. 2023 Oct;339:139656. doi: 10.1016/j.chemosphere.2023.139656. Epub 2023 Jul 25.