PMID- 37500824 OWN - NLM STAT- MEDLINE DCOM- 20240425 LR - 20240425 IS - 1476-5578 (Electronic) IS - 1359-4184 (Linking) VI - 28 IP - 12 DP - 2023 Dec TI - Magnetic resonance texture analysis reveals stagewise nonlinear alterations of the frontal gray matter in patients with early psychosis. PG - 5309-5318 LID - 10.1038/s41380-023-02163-3 [doi] AB - Although gray matter (GM) abnormalities are present from the early stages of psychosis, subtle/miniscule changes may not be detected by conventional volumetry. Texture analysis (TA), which permits quantification of the complex interrelationship between contrasts at the individual voxel level, may capture subtle GM changes with more sensitivity than does volume or cortical thickness (CTh). We performed three-dimensional TA in nine GM regions of interest (ROIs) using T1 magnetic resonance images from 101 patients with first-episode psychosis (FEP), 85 patients at clinical high risk (CHR) for psychosis, and 147 controls. Via principal component analysis, three features of gray-level cooccurrence matrix - informational measure of correlation 1 (IMC1), autocorrelation (AC), and inverse difference (ID) - were selected to analyze cortical texture in the ROIs that showed a significant change in volume or CTh in the study groups. Significant reductions in GM volume and CTh of various frontotemporal regions were found in the FEP compared with the controls. Increased frontal AC was found in the FEP group compared to the controls after adjusting for volume and CTh changes. While volume and CTh were preserved in the CHR group, a stagewise nonlinear increase in frontal IMC1 was found, which exceeded both the controls and FEP group. Increased frontal IMC1 was also associated with a lesser severity of attenuated positive symptoms in the CHR group, while neither volume nor CTh was. The results of the current study suggest that frontal IMC1 may reflect subtle, dynamic GM changes and the symptomatology of the CHR stage with greater sensitivity, even in the absence of gross GM abnormalities. Some structural mechanisms that may contribute to texture changes (e.g., macrostructural cortical lamina, neuropil/myelination, cortical reorganization) and their possible implications are explored and discussed. Texture may be a useful tool to investigate subtle and dynamic GM abnormalities, especially during the CHR period. CI - (c) 2023. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Moon, Sun Young AU - Moon SY AUID- ORCID: 0000-0001-7319-4131 AD - Department of Public Health Service, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. AD - Institute of Human Behavioral Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea. FAU - Park, Hyungyou AU - Park H AD - Department of Brain and Cognitive Science, Seoul National University College of Natural Science, Seoul, Republic of Korea. FAU - Lee, Won AU - Lee W AD - Department of Brain and Cognitive Science, Seoul National University College of Natural Science, Seoul, Republic of Korea. FAU - Lee, Subin AU - Lee S AD - Department of Brain and Cognitive Science, Seoul National University College of Natural Science, Seoul, Republic of Korea. FAU - Lho, Silvia Kyungjin AU - Lho SK AD - Research and Development Division, 40FY Inc., Seongnam, Republic of Korea. FAU - Kim, Minah AU - Kim M AUID- ORCID: 0000-0001-8668-0817 AD - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. AD - Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. FAU - Kim, Ki Woong AU - Kim KW AD - Institute of Human Behavioral Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea. AD - Department of Brain and Cognitive Science, Seoul National University College of Natural Science, Seoul, Republic of Korea. AD - Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. AD - Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. FAU - Kwon, Jun Soo AU - Kwon JS AUID- ORCID: 0000-0002-1060-1462 AD - Institute of Human Behavioral Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea. kwonjs@snu.ac.kr. AD - Department of Brain and Cognitive Science, Seoul National University College of Natural Science, Seoul, Republic of Korea. kwonjs@snu.ac.kr. AD - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. kwonjs@snu.ac.kr. AD - Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea. kwonjs@snu.ac.kr. LA - eng GR - 2020M3E5D9079910/Ministry of Science, ICT and Future Planning (MSIP)/ GR - 21-BR-03-01/Ministry of Science, ICT and Future Planning (MSIP)/ GR - 2019R1C1C100245/Seoul National University Hospital (SNUH)/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230727 PL - England TA - Mol Psychiatry JT - Molecular psychiatry JID - 9607835 SB - IM MH - Humans MH - *Gray Matter/pathology/diagnostic imaging MH - *Psychotic Disorders/pathology/diagnostic imaging MH - Female MH - Male MH - *Magnetic Resonance Imaging/methods MH - Adult MH - Young Adult MH - Adolescent MH - Frontal Lobe/pathology/diagnostic imaging MH - Image Processing, Computer-Assisted/methods MH - Principal Component Analysis/methods EDAT- 2023/07/28 01:08 MHDA- 2024/04/25 06:49 CRDT- 2023/07/27 23:28 PHST- 2022/12/15 00:00 [received] PHST- 2023/06/23 00:00 [accepted] PHST- 2023/06/13 00:00 [revised] PHST- 2024/04/25 06:49 [medline] PHST- 2023/07/28 01:08 [pubmed] PHST- 2023/07/27 23:28 [entrez] AID - 10.1038/s41380-023-02163-3 [pii] AID - 10.1038/s41380-023-02163-3 [doi] PST - ppublish SO - Mol Psychiatry. 2023 Dec;28(12):5309-5318. doi: 10.1038/s41380-023-02163-3. Epub 2023 Jul 27.