PMID- 37501703
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230801
IS  - 2772-963X (Electronic)
IS  - 2772-963X (Linking)
VI  - 2
IP  - 3
DP  - 2023 May
TI  - Refined Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary 
      Hypertension: Initial Results of U.S. Regional Program.
LID - 100291 [pii]
LID - 10.1016/j.jacadv.2023.100291 [doi]
AB  - OBJECTIVES: We sought to evaluate the efficacy and safety of refined balloon 
      pulmonary angioplasty (BPA) in the treatment of patients with chronic 
      thromboembolic pulmonary hypertension (CTEPH). BACKGROUND: BPA is rapidly 
      evolving therapeutic option for patients with nonsurgical CTEPH. There are few US 
      studies that have reported on the outcomes of this novel therapeutic option. 
      METHODS: This is a retrospective study of CTEPH patients that underwent BPA at 
      Temple University Hospital. The primary efficacy endpoint was the change in 
      pulmonary vascular resistance (PVR) after BPA as compared to baseline and the 
      primary safety endpoint was the rate of hemoptysis within 24 hours. Secondary 
      endpoints included death, WHO functional class, and 6-minute walk distance 
      (6MWD). We used logistic regression to evaluate factors associated with a 
      hemodynamic and functional response. RESULTS: A total of 211 BPA sessions were 
      performed on 77 patients (average 2.7 +/- 1.7 sessions/patient). After BPA the mean 
      PVR improved by 26% (P<0.001) while the mean 6MWD improved by 71.7 meters (P 
      <0.001) and WHO functional class improved by one functional class (P <0.001). Ten 
      sessions (4.7%) were complicated by hemoptysis. The independent factors 
      associated with a improved functional and hemodynamic response included the 
      pre-procedural use of riociguat, reduce baseline PA compliance and > 3 BPA 
      sessions per patient. CONCLUSION: This single center study from the US showed 
      that BPA with refined techniques in patients with CTEPH was safe and was 
      associated with significant improvements in pulmonary hemodynamics and functional 
      capacity.
FAU - Bashir, Riyaz
AU  - Bashir R
AD  - Division of Cardiovascular Disease, Lewis Katz School of Medicine at Temple 
      University, Philadelphia, PA.
FAU - Noory, Ali
AU  - Noory A
AD  - Cardiovascular Institute at Allegheny Health Network, Pittsburg, PA.
FAU - Oliveros, Estefania
AU  - Oliveros E
AD  - Division of Cardiovascular Disease, Lewis Katz School of Medicine at Temple 
      University, Philadelphia, PA.
FAU - Romero, Carlos
AU  - Romero C
AD  - Department of Medicine, Lewis Katz School of Medicine Temple University, 
      Philadelphia, PA.
FAU - Maruthi, Rohit
AU  - Maruthi R
AD  - Department of Medicine, Lewis Katz School of Medicine Temple University, 
      Philadelphia, PA.
FAU - Mirza, Arslan
AU  - Mirza A
AD  - Prairie Heart Institute of Illinois, Springfield IL.
FAU - Lakhter, Vladimir
AU  - Lakhter V
AD  - Division of Cardiovascular Disease, Lewis Katz School of Medicine at Temple 
      University, Philadelphia, PA.
FAU - Zhao, Huaqing
AU  - Zhao H
AD  - Department of Biomedical Education and Data Science, Temple University, 
      Philadelphia, PA.
FAU - Brisco-Bacik, Meredith
AU  - Brisco-Bacik M
AD  - Division of Cardiovascular Disease, Lewis Katz School of Medicine at Temple 
      University, Philadelphia, PA.
FAU - Vaidya, Anjali
AU  - Vaidya A
AD  - Division of Cardiovascular Disease, Lewis Katz School of Medicine at Temple 
      University, Philadelphia, PA.
FAU - Auger, William R
AU  - Auger WR
AD  - Professor Emeritus, University of California, San Diego, CA.
FAU - Forfia, Paul
AU  - Forfia P
AD  - Division of Cardiovascular Disease, Lewis Katz School of Medicine at Temple 
      University, Philadelphia, PA.
LA  - eng
GR  - R44 HL151032/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20230412
PL  - United States
TA  - JACC Adv
JT  - JACC. Advances
JID - 9918419284106676
PMC - PMC10373249
MID - NIHMS1909594
OTO - NOTNLM
OT  - Balloon pulmonary angioplasty
OT  - Chronic thromboembolic pulmonary disease
OT  - Chronic thromboembolic pulmonary hypertension
COIS- The other authors report no conflicts.
EDAT- 2023/07/28 06:43
MHDA- 2023/07/28 06:44
PMCR- 2023/07/27
CRDT- 2023/07/28 04:04
PHST- 2023/07/28 06:44 [medline]
PHST- 2023/07/28 06:43 [pubmed]
PHST- 2023/07/28 04:04 [entrez]
PHST- 2023/07/27 00:00 [pmc-release]
AID - 100291 [pii]
AID - 10.1016/j.jacadv.2023.100291 [doi]
PST - ppublish
SO  - JACC Adv. 2023 May;2(3):100291. doi: 10.1016/j.jacadv.2023.100291. Epub 2023 Apr 
      12.