PMID- 37501897 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230729 IS - 2186-2494 (Electronic) IS - 1882-4072 (Print) IS - 1882-4072 (Linking) VI - 16 IP - 6 DP - 2022 TI - Bleb Embolization of Ruptured Cerebral Aneurysms with Coils and n-Butyl Cyanoacrylate Following Proximal Flow Control: Two Case Reports. PG - 313-319 LID - 10.5797/jnet.cr.2021-0082 [doi] AB - OBJECTIVE: Morphologically challenging cerebral aneurysms cannot be treated through standard endovascular procedures. We report two cases of ruptured aneurysms treated using coils and n-butyl cyanoacrylate (NBCA). CASE PRESENTATIONS: Case 1 was an 80-year-old woman diagnosed with a subarachnoid hemorrhage (SAH). An angiogram revealed a large and wide-necked basilar artery bifurcation aneurysm. Bilateral superior cerebellar and posterior cerebral arteries (PCAs) originated from the aneurysmal wall. A 3-mm-diameter bleb was detected on the aneurysmal fundus. The bleb enlarged 1 month following coil insertion. During the second treatment, we infused a small volume of 33% NBCA into the coil-framed bleb following proximal flow control of the bilateral vertebral arteries (VAs). The complete bleb obliteration was confirmed by the angiogram at 6 months later. The coil shape was followed up via plane X-ray for 5 years. No rebleeding occurred. Case 2 was a 41-year-old woman diagnosed with SAH. An angiogram revealed a dissecting aneurysm of the left PCA (P1 and P2 segments) accompanying a bleb on the P1 segment. Endovascular treatment was performed, and a coil was inserted into the bleb, infusing 33% NBCA into the coil frame following proximal flow control of bilateral VAs and the right internal carotid artery. Angiograms conducted at 3 months, 1 year, and 9 years and an MRA conducted 12 years later revealed a lack of bleb recanalization. CONCLUSION: We developed a Coil and NBCA technique to obliterate ruptured blebs following proximal flow control. This technique can be considered an effective alternative for treating morphologically challenging cerebral aneurysms. CI - (c)2022 The Japanese Society for Neuroendovascular Therapy. FAU - Tone, Osamu AU - Tone O AD - Stroke Center, Ome Municipal General Hospital, Ome, Tokyo, Japan. FAU - Sato, Yohei AU - Sato Y AD - Department of Neurosurgery, Japanese Red Cross Musashino Hospital, Musashino, Tokyo, Japan. FAU - Tamaki, Masashi AU - Tamaki M AD - Department of Neurosurgery, Japanese Red Cross Musashino Hospital, Musashino, Tokyo, Japan. FAU - Takada, Yoshiaki AU - Takada Y AD - Department of Neurosurgery, Ome Municipal General Hospital, Ome, Tokyo, Japan. LA - eng PT - Case Reports DEP - 20211001 PL - Japan TA - J Neuroendovasc Ther JT - Journal of neuroendovascular therapy JID - 101488164 PMC - PMC10370545 OTO - NOTNLM OT - balloon occlusion OT - basilar artery OT - endovascular technique OT - posterior cerebral artery OT - subarachnoid hemorrhage COIS- The authors declare that they have no conflicts of interest. EDAT- 2022/01/01 00:00 MHDA- 2022/01/01 00:01 PMCR- 2022/01/01 CRDT- 2023/07/28 04:07 PHST- 2021/07/02 00:00 [received] PHST- 2021/08/14 00:00 [accepted] PHST- 2022/01/01 00:01 [medline] PHST- 2022/01/01 00:00 [pubmed] PHST- 2023/07/28 04:07 [entrez] PHST- 2022/01/01 00:00 [pmc-release] AID - jnet.cr.2021-0082 [pii] AID - 10.5797/jnet.cr.2021-0082 [doi] PST - ppublish SO - J Neuroendovasc Ther. 2022;16(6):313-319. doi: 10.5797/jnet.cr.2021-0082. Epub 2021 Oct 1.