PMID- 37502767
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230729
IS  - 2186-2494 (Electronic)
IS  - 1882-4072 (Print)
IS  - 1882-4072 (Linking)
VI  - 15
IP  - 8
DP  - 2021
TI  - Periprocedural Variability of Platelet Functions in Carotid Artery Stenting: An 
      Analysis Using VerifyNow.
PG  - 505-516
LID - 10.5797/jnet.oa.2020-0170 [doi]
AB  - OBJECTIVE: The assessment of platelet functions is necessary to prevent both 
      thromboembolic and hemorrhagic complications under dual antiplatelet therapy 
      (DAPT). Using the VerifyNow (Accumetrics, Inc., San Diego, CA, USA) assay, this 
      study aimed to reveal time-dependent changes in platelet functions after carotid 
      artery stenting (CAS). METHODS: We enrolled retrospectively 43 patients who 
      underwent CAS under DAPT. Aspirin reaction unit (ARU) and P2Y12 reaction unit 
      (PRU) values were determined on the day before and on days 1, 3, and 7 after the 
      procedure. Multiple comparison tests (MCTs) were performed among ARU and PRU 
      measurement points, and the proportions of hypo- and hyper-responses were 
      compared. RESULTS: The median ARU values were 408 (interquartile range: 392-497) 
      before CAS and 418 (405-470) on day 1, 405 (393.0-460.5) on day 3, and 402 
      (388.5-477.5) on day 7 (not significant in MCTs). The percentages of 
      hypo-responses were 16.3%, 7.0%, 2.3%, and 7.0%, respectively (p = 0.11). The 
      significantly different median PRU values were 173 (116.5-209.5), 233 
      (166.5-273.5), 139 (70.5-205.5), and 51 (9.0-79.5), respectively. The median PRU 
      was before the procedure within the therapeutic range but exceeded the upper 
      cutoff on day 1 and was below the lower cutoff on day 7. The percentages of 
      hypo-responses were 14.0%, 51.2%, 18.6%, and 11.6%, respectively (p <0.001) and 
      the percentages of hyper-responses were 9.3%, 2.3%, 23.3%, and 62.8%, 
      respectively (p <0.001). CONCLUSION: In the periprocedural CAS period, ARU values 
      were stable, but PRU values showed time-dependent changes. PRU values were above 
      the therapeutic range the day after CAS but decreased below this range on day 7.
CI  - (c)2021 The Japanese Society for Neuroendovascular Therapy.
FAU - Yoshimura, Masataka
AU  - Yoshimura M
AD  - Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan.
AD  - Department of Neurosurgery, Tsuchiura Kyodo General Hospital, Tsuchiura, Ibaraki, 
      Japan.
FAU - Sumita, Kazutaka
AU  - Sumita K
AD  - Department of Endovascular Surgery, Tokyo Medical and Dental University, Tokyo, 
      Japan.
FAU - Fujii, Shoko
AU  - Fujii S
AD  - Department of Endovascular Surgery, Tokyo Medical and Dental University, Tokyo, 
      Japan.
FAU - Miki, Kazunori
AU  - Miki K
AD  - Department of Endovascular Surgery, Tokyo Medical and Dental University, Tokyo, 
      Japan.
FAU - Aizawa, Yuki
AU  - Aizawa Y
AD  - Department of Endovascular Surgery, Tokyo Medical and Dental University, Tokyo, 
      Japan.
FAU - Fujita, Kyohei
AU  - Fujita K
AD  - Department of Endovascular Surgery, Tokyo Medical and Dental University, Tokyo, 
      Japan.
FAU - Yamamoto, Shinji
AU  - Yamamoto S
AD  - Department of Neurosurgery, Tsuchiura Kyodo General Hospital, Tsuchiura, Ibaraki, 
      Japan.
FAU - Nemoto, Shigeru
AU  - Nemoto S
AD  - Department of Endovascular Surgery, Tokyo Medical and Dental University, Tokyo, 
      Japan.
FAU - Maehara, Taketoshi
AU  - Maehara T
AD  - Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210106
PL  - Japan
TA  - J Neuroendovasc Ther
JT  - Journal of neuroendovascular therapy
JID - 101488164
PMC - PMC10370580
OTO - NOTNLM
OT  - VerifyNow
OT  - carotid artery stenting
OT  - platelet function
COIS- The authors report no conflicts of interest concerning the materials or methods 
      used in this study or the findings specified in this paper.
EDAT- 2021/01/01 00:00
MHDA- 2021/01/01 00:01
PMCR- 2021/01/01
CRDT- 2023/07/28 04:21
PHST- 2020/09/03 00:00 [received]
PHST- 2020/10/31 00:00 [accepted]
PHST- 2021/01/01 00:01 [medline]
PHST- 2021/01/01 00:00 [pubmed]
PHST- 2023/07/28 04:21 [entrez]
PHST- 2021/01/01 00:00 [pmc-release]
AID - jnet.oa.2020-0170 [pii]
AID - 10.5797/jnet.oa.2020-0170 [doi]
PST - ppublish
SO  - J Neuroendovasc Ther. 2021;15(8):505-516. doi: 10.5797/jnet.oa.2020-0170. Epub 
      2021 Jan 6.