PMID- 37503638
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240408
IS  - 1557-7716 (Electronic)
IS  - 1523-0864 (Linking)
VI  - 40
IP  - 10-12
DP  - 2024 Apr
TI  - NRF2: New Mechanistic Insights and Therapeutic Perspectives.
PG  - 632-635
LID - 10.1089/ars.2023.0398 [doi]
AB  - Targeted modulation of a dynamic interplay between transcription factor nuclear 
      factor erythroid 2-related factor 2 (NRF2) and its negative regulator, Kelch-like 
      ECH-associated protein 1 (KEAP1), is of paramount importance in maintaining 
      redox, metabolic, and protein homeostasis and regulating inflammation responses. 
      Indeed, inducible NRF2 activation promotes cytoprotective mechanisms against many 
      immune, neurodegenerative, and metabolic disorders with oxidative stress and 
      inflammation as underlying pathological features. In this ARS Forum, five 
      state-of-the-art reviews and two original research communications report on 
      canonical and newly discovered molecular mechanisms by which the NRF2-KEAP1 axis 
      controls fundamental cell life or death decisions and exerts biological functions 
      under environmental and endogenous stress conditions. Although the use of NRF2 
      activators represents a promising pharmacological strategy to regain and maintain 
      homeostasis, challenges regarding their double-edged character, target 
      specificity, pharmacodynamic properties, efficacy, and safety must be critically 
      considered. More translational studies are warranted before NRF2 agonists 
      (inducers or enhancers) become an integral part of our therapeutic armamentarium. 
      Antioxid. Redox Signal. 40, 632-635.
FAU - Kupiec-Weglinski, Jerzy W
AU  - Kupiec-Weglinski JW
AUID- ORCID: 0000-0001-8976-4872
AD  - The Dumont-UCLA Transplantation Center, Division of Liver and Pancreas 
      Transplantation, Department of Surgery, David Geffen School of Medicine at UCLA, 
      Los Angeles, California, USA.
LA  - eng
PT  - Editorial
DEP - 20230905
PL  - United States
TA  - Antioxid Redox Signal
JT  - Antioxidants & redox signaling
JID - 100888899
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Kelch-Like ECH-Associated Protein 1)
SB  - IM
MH  - Humans
MH  - *NF-E2-Related Factor 2/metabolism
MH  - Kelch-Like ECH-Associated Protein 1/metabolism
MH  - *Oxidative Stress
MH  - Inflammation/metabolism
MH  - Oxidation-Reduction
OTO - NOTNLM
OT  - HO-1
OT  - KEAP1
OT  - NRF2
EDAT- 2023/07/28 06:42
MHDA- 2024/04/08 06:43
CRDT- 2023/07/28 05:28
PHST- 2024/04/08 06:43 [medline]
PHST- 2023/07/28 06:42 [pubmed]
PHST- 2023/07/28 05:28 [entrez]
AID - 10.1089/ars.2023.0398 [doi]
PST - ppublish
SO  - Antioxid Redox Signal. 2024 Apr;40(10-12):632-635. doi: 10.1089/ars.2023.0398. 
      Epub 2023 Sep 5.