PMID- 37504282
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230731
IS  - 1467-3045 (Electronic)
IS  - 1467-3037 (Print)
IS  - 1467-3037 (Linking)
VI  - 45
IP  - 7
DP  - 2023 Jul 12
TI  - HLA-G Alleles Impact the Perinatal Father-Child HPV Transmission.
PG  - 5798-5810
LID - 10.3390/cimb45070366 [doi]
AB  - The host factors that influence father-to-child human papillomavirus (HPV) 
      transmission remain unknown. This study evaluated whether human leukocyte antigen 
      (HLA)-G alleles are important in father-to-child HPV transmission during the 
      perinatal period. Altogether, 134 father-newborn pairs from the Finnish Family 
      HPV Study were included. Oral, semen and urethral samples from the fathers were 
      collected before the delivery, and oral samples were collected from their 
      offspring at delivery and postpartum on day 3 and during 1-, 2- and 6-month 
      follow-up visits. HLA-G alleles were tested by direct sequencing. Unconditional 
      logistic regression was used to determine the association of the father-child 
      HLA-G allele and genotype concordance with the father-child HPV prevalence and 
      concordance at birth and during follow-up. HLA-G allele G*01:01:03 concordance 
      was associated with the father's urethral and child's oral high-risk (HR)-HPV 
      concordance at birth (OR 17.00, 95% CI: 1.24-232.22). HLA-G allele G*01:04:01 
      concordance increased the father's oral and child's postpartum oral any- and 
      HR-HPV concordance with an OR value of 7.50 (95% CI: 1.47-38.16) and OR value of 
      7.78 (95% CI: 1.38-43.85), respectively. There was no association between 
      different HLA-G genotypes and HPV concordance among the father-child pairs at 
      birth or postpartum. To conclude, the HLA-G allele concordance appears to impact 
      the HPV transmission between the father and his offspring.
FAU - Suominen, Nelli T
AU  - Suominen NT
AD  - Department of Obstetrics and Gynecology, Turku University Hospital, University of 
      Turku, 20520 Turku, Finland.
AD  - Department of Obstetrics and Gynecology, Vaasa Central Hospital, 65130 Vaasa, 
      Finland.
FAU - Roger, Michel
AU  - Roger M
AD  - Departement de Microbiologie et d'Immunologie et Centre de Recherche du Centre 
      Hospitalier de l'Universite de Montreal (CHUM), Montreal, QC H2X 0A9, Canada.
AD  - Department of Microbiology, Infectious Diseases and Immunology, University of 
      Montreal, Montreal, QC H3T 1J4, Canada.
FAU - Faucher, Marie-Claude
AU  - Faucher MC
AD  - Departement de Microbiologie et d'Immunologie et Centre de Recherche du Centre 
      Hospitalier de l'Universite de Montreal (CHUM), Montreal, QC H2X 0A9, Canada.
FAU - Syrjanen, Kari J
AU  - Syrjanen KJ
AD  - Department of Clinical Research, Biohit Oyj, 00880 Helsinki, Finland.
FAU - Grenman, Seija E
AU  - Grenman SE
AD  - Department of Obstetrics and Gynecology, Turku University Hospital, University of 
      Turku, 20520 Turku, Finland.
FAU - Syrjanen, Stina M
AU  - Syrjanen SM
AD  - Department of Oral Pathology and Radiology, University of Turku, 20520 Turku, 
      Finland.
AD  - Department of Pathology, Turku University Hospital, 20520 Turku, Finland.
FAU - Louvanto, Karolina
AU  - Louvanto K
AUID- ORCID: 0000-0002-1172-363X
AD  - Department of Oral Pathology and Radiology, University of Turku, 20520 Turku, 
      Finland.
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine and Health 
      Technology, Tampere University, 33100 Tampere, Finland.
AD  - Department of Obstetrics and Gynecology, Tampere University Hospital, 33520 
      Tampere, Finland.
LA  - eng
GR  - Sigrid Juselius Foundation/
GR  - Finnish Medical Foundation/
GR  - Academy of Finland/
GR  - Finnish Cancer Foundation/
GR  - Paivikki and Sakari Sohlberg Foundation/
GR  - The Goverment Special Foundation (EVO) to Turku University Hospital/
PT  - Journal Article
DEP - 20230712
PL  - Switzerland
TA  - Curr Issues Mol Biol
JT  - Current issues in molecular biology
JID - 100931761
PMC - PMC10378566
OTO - NOTNLM
OT  - HLA-G
OT  - HPV
OT  - father
OT  - human papillomavirus
OT  - transmission
OT  - vertical
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/28 13:11
MHDA- 2023/07/28 13:12
PMCR- 2023/07/12
CRDT- 2023/07/28 08:34
PHST- 2023/06/10 00:00 [received]
PHST- 2023/07/09 00:00 [revised]
PHST- 2023/07/11 00:00 [accepted]
PHST- 2023/07/28 13:12 [medline]
PHST- 2023/07/28 13:11 [pubmed]
PHST- 2023/07/28 08:34 [entrez]
PHST- 2023/07/12 00:00 [pmc-release]
AID - cimb45070366 [pii]
AID - cimb-45-00366 [pii]
AID - 10.3390/cimb45070366 [doi]
PST - epublish
SO  - Curr Issues Mol Biol. 2023 Jul 12;45(7):5798-5810. doi: 10.3390/cimb45070366.