PMID- 37504981
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230801
IS  - 2077-0375 (Print)
IS  - 2077-0375 (Electronic)
IS  - 2077-0375 (Linking)
VI  - 13
IP  - 7
DP  - 2023 Jun 21
TI  - Influence of Nitrosyl Iron Complex with Thiosulfate Ligands on Therapeutically 
      Important Targets Related to Type 2 Diabetes Mellitus.
LID - 10.3390/membranes13070615 [doi]
LID - 615
AB  - The high prevalence of type 2 diabetes mellitus (T2DM), and the lack of effective 
      therapy, determine the need for new treatment options. The present study is 
      focused on the NO-donors drug class as effective antidiabetic agents. Since 
      numerous biological systems are involved in the pathogenesis and progression of 
      T2DM, the most promising approach to the development of effective drugs for the 
      treatment of T2DM is the search for pharmacologically active compounds that are 
      selective for a number of therapeutic targets for T2DM and its complications: 
      oxidative stress, non-enzymatic protein glycation, polyol pathway. The nitrosyl 
      iron complex with thiosulfate ligands was studied in this work. Binuclear iron 
      nitrosyl complexes are synthetic analogues of [2Fe-2S] centers in the regulatory 
      protein natural reservoirs of NO. Due to their ability to release NO without 
      additional activation under physiological conditions, these compounds are of 
      considerable interest for the development of potential drugs. The present study 
      explores the effects of tetranitrosyl iron complex with thiosulfate ligands 
      (TNIC-ThS) on T2DM and its complications regarding therapeutic targets in vitro, 
      as well as its ability to bind liposomal membrane, inhibit lipid peroxidation 
      (LPO), and non-enzymatic glycation of bovine serum albumin (BSA), as well as 
      aldose reductase, the enzyme that catalyzes the reduction in glucose to sorbitol 
      in the polyol pathway. Using the fluorescent probe method, it has been shown that 
      TNIC-ThS molecules interact with both hydrophilic and hydrophobic regions of 
      model membranes. TNIC-ThS inhibits lipid peroxidation, exhibiting antiradical 
      activity due to releasing NO (IC50 = 21.5 +/- 3.7 microM). TNIC-ThS was found to show 
      non-competitive inhibition of aldose reductase with Ki value of 5.25 x 10(-4) M. 
      In addition, TNIC-ThS was shown to be an effective inhibitor of the process of 
      non-enzymatic protein glycation in vitro (IC50 = 47.4 +/- 7.6 microM). Thus, TNIC-ThS 
      may be considered to contribute significantly to the treatment of T2DM and 
      diabetic complications.
FAU - Faingold, Irina I
AU  - Faingold II
AUID- ORCID: 0000-0003-4926-3859
AD  - Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, 
      Russian Academy of Sciences, Academician Semenov Avenue 1, Chernogolovka 142432, 
      Russia.
FAU - Soldatova, Yuliya V
AU  - Soldatova YV
AUID- ORCID: 0000-0002-6929-0638
AD  - Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, 
      Russian Academy of Sciences, Academician Semenov Avenue 1, Chernogolovka 142432, 
      Russia.
FAU - Poletaeva, Darya A
AU  - Poletaeva DA
AUID- ORCID: 0000-0002-4315-9180
AD  - Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, 
      Russian Academy of Sciences, Academician Semenov Avenue 1, Chernogolovka 142432, 
      Russia.
FAU - Klimanova, Elena N
AU  - Klimanova EN
AD  - Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, 
      Russian Academy of Sciences, Academician Semenov Avenue 1, Chernogolovka 142432, 
      Russia.
FAU - Sanina, Nataliya A
AU  - Sanina NA
AUID- ORCID: 0000-0002-5344-6220
AD  - Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, 
      Russian Academy of Sciences, Academician Semenov Avenue 1, Chernogolovka 142432, 
      Russia.
AD  - Medicinal Chemistry Research and Education Center, Moscow Region State 
      University, Mytishchy 142432, Russia.
LA  - eng
GR  - grant No. 22-24-00764./Russian Science Foundation/
GR  - number capital A, Cyrilliccapital A, Cyrilliccapital A, Cyrilliccapital A, Cyrillic-capital A, Cyrillic19-119071890015-6./the Ministry of Science and Education of the 
      Russian Federation, State task/
PT  - Journal Article
DEP - 20230621
PL  - Switzerland
TA  - Membranes (Basel)
JT  - Membranes
JID - 101577807
PMC - PMC10384030
OTO - NOTNLM
OT  - aldose reductase
OT  - anti-glycation activity
OT  - liposomes
OT  - membranotropic properties
OT  - model membrane
OT  - nitric oxide
OT  - nitrosyl iron complexes
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/28 13:10
MHDA- 2023/07/28 13:11
PMCR- 2023/06/21
CRDT- 2023/07/28 09:43
PHST- 2023/05/04 00:00 [received]
PHST- 2023/06/15 00:00 [revised]
PHST- 2023/06/19 00:00 [accepted]
PHST- 2023/07/28 13:11 [medline]
PHST- 2023/07/28 13:10 [pubmed]
PHST- 2023/07/28 09:43 [entrez]
PHST- 2023/06/21 00:00 [pmc-release]
AID - membranes13070615 [pii]
AID - membranes-13-00615 [pii]
AID - 10.3390/membranes13070615 [doi]
PST - epublish
SO  - Membranes (Basel). 2023 Jun 21;13(7):615. doi: 10.3390/membranes13070615.