PMID- 37505669 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230801 IS - 2414-6366 (Electronic) IS - 2414-6366 (Linking) VI - 8 IP - 7 DP - 2023 Jul 19 TI - Adherence and Toxicity during the Treatment of Latent Tuberculous Infection in a Referral Center in Spain. LID - 10.3390/tropicalmed8070373 [doi] LID - 373 AB - The screening and treatment of latent tuberculosis infection (LTBI) in countries with a low incidence of TB is a key strategy for the elimination of tuberculosis (TB). However, treatment can result in adverse events (AEs) and have poor adherence. This study aimed to describe treatment outcomes and AEs for LTBI patients at two departments in Vall d'Hebron University Hospital in Barcelona, Spain. A retrospective study was conducted on all persons treated for LTBI between January 2018 and December 2020. Variables collected included demographics, the reason for LTBI screening and treatment initiation, AEs related to treatment, and treatment outcome. Out of 261 persons who initiated LTBI treatment, 145 (55.6%) were men, with a median age of 42.1 years. The indications for LTBI screening were household contact of a TB case in 96 (36.8%) persons, immunosuppressive treatment in 84 (32.2%), and recently arrived migrants from a country with high TB incidence in 81 (31.0%). Sixty-three (24.1%) persons presented at least one AE during treatment, and seven (2.7%) required definitive discontinuation of treatment. In the multivariate analysis, AE development was more frequent in those who started LTBI treatment due to immunosuppression. Overall, 226 (86.6%) completed treatment successfully. We concluded that LTBI screening and treatment groups had different risks for adverse events and treatment outcomes. Persons receiving immunosuppressive treatment were at higher risk of developing AEs, and recently arrived immigrants from countries with a high incidence of TB had greater LTFU. A person-centered adherence and AE management plan is recommended. FAU - Puyana Ortiz, Juan David AU - Puyana Ortiz JD AD - International Health and Cooperation UAB, 08193 Barcelona, Spain. FAU - Garces Rodriguez, Andrea Carolina AU - Garces Rodriguez AC AUID- ORCID: 0000-0002-9393-1220 AD - Morales Meseguer University Hospital, 30008 Murcia, Spain. FAU - Aznar, Maria Luisa AU - Aznar ML AUID- ORCID: 0000-0001-9223-7790 AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Grupo de Estudio de Micobacterias (GEIM), Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC), 28003 Madrid, Spain. FAU - Espinosa Pereiro, Juan AU - Espinosa Pereiro J AUID- ORCID: 0000-0002-7238-8337 AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Grupo de Estudio de Micobacterias (GEIM), Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC), 28003 Madrid, Spain. FAU - Sanchez-Montalva, Adrian AU - Sanchez-Montalva A AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Grupo de Estudio de Micobacterias (GEIM), Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC), 28003 Madrid, Spain. FAU - Martinez-Camprecios, Joan AU - Martinez-Camprecios J AUID- ORCID: 0000-0002-8899-8447 AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Saborit, Nuria AU - Saborit N AUID- ORCID: 0000-0001-5193-3597 AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. FAU - Rodrigo-Pendas, Jose Angel AU - Rodrigo-Pendas JA AD - Preventive Medicine and Epidemiology Department, Vall d'Hebron University Hospital, 08035 Barcelona, Spain. FAU - Garcia Salgado, Guadalupe AU - Garcia Salgado G AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. FAU - Broto Cortes, Claudia AU - Broto Cortes C AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. FAU - Delcor, Nuria Serre AU - Delcor NS AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Oliveira, Ines AU - Oliveira I AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Trevino Maruri, Begona AU - Trevino Maruri B AUID- ORCID: 0000-0003-4633-8288 AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Ciruelo, Diana Pou AU - Ciruelo DP AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Salvador, Fernando AU - Salvador F AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Bosch-Nicolau, Pau AU - Bosch-Nicolau P AUID- ORCID: 0000-0002-7435-1829 AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Torrecilla-Martinez, Irene AU - Torrecilla-Martinez I AUID- ORCID: 0009-0007-6532-8807 AD - Preventive Medicine and Epidemiology Department, Vall d'Hebron University Hospital, 08035 Barcelona, Spain. FAU - Zules-Ona, Ricardo AU - Zules-Ona R AUID- ORCID: 0000-0002-3648-4321 AD - Preventive Medicine and Epidemiology Department, Vall d'Hebron University Hospital, 08035 Barcelona, Spain. FAU - Tortola Fernandez, Maria Teresa AU - Tortola Fernandez MT AUID- ORCID: 0000-0002-9188-298X AD - Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Microbiology Department, Vall d'Hebron University Hospital, 08035 Barcelona, Spain. FAU - Molina, Israel AU - Molina I AD - International Health Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Vall d'Hebron University Hospital, PROSICS Barcelona, 08001 Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain. LA - eng PT - Journal Article DEP - 20230719 PL - Switzerland TA - Trop Med Infect Dis JT - Tropical medicine and infectious disease JID - 101709042 PMC - PMC10383852 OTO - NOTNLM OT - Mycobacterium tuberculosis OT - adherence OT - adverse events OT - latent tuberculosis infection OT - toxicity OT - tuberculosis screening COIS- The authors declare no conflict of interest. EDAT- 2023/07/28 13:10 MHDA- 2023/07/28 13:11 PMCR- 2023/07/19 CRDT- 2023/07/28 11:43 PHST- 2023/05/18 00:00 [received] PHST- 2023/07/12 00:00 [revised] PHST- 2023/07/13 00:00 [accepted] PHST- 2023/07/28 13:11 [medline] PHST- 2023/07/28 13:10 [pubmed] PHST- 2023/07/28 11:43 [entrez] PHST- 2023/07/19 00:00 [pmc-release] AID - tropicalmed8070373 [pii] AID - tropicalmed-08-00373 [pii] AID - 10.3390/tropicalmed8070373 [doi] PST - epublish SO - Trop Med Infect Dis. 2023 Jul 19;8(7):373. doi: 10.3390/tropicalmed8070373.