PMID- 37505993 OWN - NLM STAT- MEDLINE DCOM- 20230731 LR - 20230821 IS - 1468-2834 (Electronic) IS - 0002-0729 (Linking) VI - 52 IP - 7 DP - 2023 Jul 1 TI - Investigating three ways of measuring the intrinsic capacity domain of vitality: nutritional status, handgrip strength and ageing biomarkers. LID - afad133 [pii] LID - 10.1093/ageing/afad133 [doi] AB - BACKGROUND: Vitality is conceptually considered as the underlying capacity influencing other intrinsic capacity (IC) domains and being related to nutrition, physiological reserve and biological ageing. However, there is no consensus on its operationalisation. OBJECTIVE: To investigate the structure and magnitude of the association of vitality with other IC domains and functional difficulties using three operational definitions of vitality. METHODS: We included 1,389 older adults from the Multidomain Alzheimer Preventive Trial with data on Mini Nutritional Assessment (MNA), handgrip strength and plasma biomarkers (comprising inflammatory and mitochondrial markers). Using path analysis, we examined the effects of vitality on difficulties in basic and instrumental activities of daily living (ADL and IADL) exerted directly and indirectly through the mediation of other IC domains: cognition, locomotion, psychological, vision and hearing. We further explored the longitudinal association of vitality with IC domains, ADL and IADL over 4 years using linear mixed-effect regression. RESULTS: We observed significant indirect effects of vitality on IADL, mainly through cognitive, locomotor and psychological domains, regardless of the vitality measurement. Participants with higher vitality had fewer IADL difficulties at follow-up (MNA score: beta [95% CI] = -0.020 [-0.037, -0.003]; handgrip strength: -0.011 [-0.023, 0.000]; plasma biomarker-based index: -0.015 [-0.028, -0.002]). Vitality assessed with the plasma biomarker-based index predicted improved locomotion over time. CONCLUSION: Vitality was associated with disability primarily through the mediation of other IC domains. The three indicators examined are acceptable measurements of vitality; biomarkers might be more suitable for the early detection of locomotion decline. CI - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com. FAU - Lu, Wan-Hsuan AU - Lu WH AUID- ORCID: 0000-0001-7824-4214 AD - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), 31000 Toulouse, France. AD - Maintain Aging Research Team, Centre d'Epidemiologie et de Recherche en sante des POPulations (CERPOP), Inserm, Universite Paul Sabatier, Toulouse, France. FAU - Gonzalez-Bautista, Emmanuel AU - Gonzalez-Bautista E AUID- ORCID: 0000-0001-9844-3034 AD - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), 31000 Toulouse, France. AD - Maintain Aging Research Team, Centre d'Epidemiologie et de Recherche en sante des POPulations (CERPOP), Inserm, Universite Paul Sabatier, Toulouse, France. FAU - Guyonnet, Sophie AU - Guyonnet S AD - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), 31000 Toulouse, France. AD - Maintain Aging Research Team, Centre d'Epidemiologie et de Recherche en sante des POPulations (CERPOP), Inserm, Universite Paul Sabatier, Toulouse, France. FAU - Martinez, Laurent O AU - Martinez LO AD - Institut National de la Sante et de la Recherche Medicale (INSERM), UMR 1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France. FAU - Lucas, Alexandre AU - Lucas A AD - Institut National de la Sante et de la Recherche Medicale (INSERM), UMR 1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France. FAU - Parini, Angelo AU - Parini A AD - Institut National de la Sante et de la Recherche Medicale (INSERM), UMR 1297, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France. FAU - Rolland, Yves AU - Rolland Y AD - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), 31000 Toulouse, France. AD - Maintain Aging Research Team, Centre d'Epidemiologie et de Recherche en sante des POPulations (CERPOP), Inserm, Universite Paul Sabatier, Toulouse, France. FAU - Vellas, Bruno AU - Vellas B AD - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), 31000 Toulouse, France. AD - Maintain Aging Research Team, Centre d'Epidemiologie et de Recherche en sante des POPulations (CERPOP), Inserm, Universite Paul Sabatier, Toulouse, France. FAU - de Souto Barreto, Philipe AU - de Souto Barreto P AD - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), 31000 Toulouse, France. AD - Maintain Aging Research Team, Centre d'Epidemiologie et de Recherche en sante des POPulations (CERPOP), Inserm, Universite Paul Sabatier, Toulouse, France. CN - MAPT/DSA Group LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Age Ageing JT - Age and ageing JID - 0375655 RN - 0 (Biomarkers) SB - IM CIN - Age Ageing. 2023 Aug 1;52(8):. PMID: 37585591 MH - Humans MH - Aged MH - *Nutritional Status MH - Activities of Daily Living MH - Hand Strength/physiology MH - *Alzheimer Disease MH - Geriatric Assessment MH - Aging MH - Biomarkers OTO - NOTNLM OT - biological ageing OT - disability OT - healthy ageing OT - inflammation OT - older people OT - structural equation modelling FIR - Vellas, Bruno IR - Vellas B FIR - Guyonnet, Sophie IR - Guyonnet S FIR - Carrie, Isabelle IR - Carrie I FIR - Brigitte, Laureane IR - Brigitte L FIR - Faisant, Catherine IR - Faisant C FIR - Lala, Francoise IR - Lala F FIR - Delrieu, Julien IR - Delrieu J FIR - Villars, Helene IR - Villars H FIR - Combrouze, Emeline IR - Combrouze E FIR - Badufle, Carole IR - Badufle C FIR - Zueras, Audrey IR - Zueras A FIR - Andrieu, Sandrine IR - Andrieu S FIR - Cantet, Christelle IR - Cantet C FIR - Morin, Christophe IR - Morin C FIR - Van Kan, Gabor Abellan IR - Van Kan GA FIR - Dupuy, Charlotte IR - Dupuy C FIR - Rolland, Yves IR - Rolland Y FIR - Caillaud, Celine IR - Caillaud C FIR - Ousset, Pierre-Jean IR - Ousset PJ FIR - Lala, Francoise IR - Lala F FIR - Dartigues, Jean-Francois IR - Dartigues JF FIR - Marcet, Isabelle IR - Marcet I FIR - Delva, Fleur IR - Delva F FIR - Foubert, Alexandra IR - Foubert A FIR - Cerda, Sandrine IR - Cerda S FIR - Rouaud, Olivier IR - Rouaud O FIR - Manckoundia, Patrick IR - Manckoundia P FIR - Quipourt, Valerie IR - Quipourt V FIR - Marilier, Sophie IR - Marilier S FIR - Franon, Evelyne IR - Franon E FIR - Bories, Lawrence IR - Bories L FIR - Pader, Marie-Laure IR - Pader ML FIR - Basset, Marie-France IR - Basset MF FIR - Lapoujade, Bruno IR - Lapoujade B FIR - Faure, Valerie IR - Faure V FIR - Li Yung Tong, Michael IR - Li Yung Tong M FIR - Malick-Loiseau, Christine IR - Malick-Loiseau C FIR - Cazaban-Campistron, Evelyne IR - Cazaban-Campistron E FIR - Desclaux, Francoise IR - Desclaux F FIR - Blatge, Colette IR - Blatge C FIR - Dantoine, Thierry IR - Dantoine T FIR - Laubarie-Mouret, Cecile IR - Laubarie-Mouret C FIR - Saulnier, Isabelle IR - Saulnier I FIR - Clement, Jean-Pierre IR - Clement JP FIR - Picat, Marie-Agnes IR - Picat MA FIR - Bernard-Bourzeix, Laurence IR - Bernard-Bourzeix L FIR - Willebois, Stephanie IR - Willebois S FIR - Desormais, Ileana IR - Desormais I FIR - Cardinaud, Noelle IR - Cardinaud N FIR - Bonnefoy, Marc IR - Bonnefoy M FIR - Livet, Pierre IR - Livet P FIR - Rebaudet, Pascale IR - Rebaudet P FIR - Gedeon, Claire IR - Gedeon C FIR - Burdet, Catherine IR - Burdet C FIR - Pesce, Alain IR - Pesce A FIR - Roth, Stephanie IR - Roth S FIR - Chaillou, Sylvie IR - Chaillou S FIR - Sudres, Kristel IR - Sudres K FIR - Lebrun, Nicolas IR - Lebrun N FIR - Touchon, Jacques IR - Touchon J FIR - Bennys, Karim IR - Bennys K FIR - Gabelle, Audrey IR - Gabelle A FIR - Romano, Aurelia IR - Romano A FIR - Touati, Lynda IR - Touati L FIR - Marelli, Cecilia IR - Marelli C FIR - Le Duff, Franck IR - Le Duff F FIR - Gervais, Claire IR - Gervais C FIR - Gonfrier, Sebastien IR - Gonfrier S FIR - Gasnier, Yannick IR - Gasnier Y FIR - Bordes, Serge IR - Bordes S FIR - Begorre, Daniele IR - Begorre D FIR - Carpuat, Christian IR - Carpuat C FIR - Khales, Khaled IR - Khales K FIR - Lefebvre, Jean-Francois IR - Lefebvre JF FIR - El Idrissi, Samira Misbah IR - El Idrissi SM FIR - Skolil, Pierre IR - Skolil P FIR - Salles, Jean-Pierre IR - Salles JP FIR - Dufouil, Carole IR - Dufouil C FIR - Lehericy, Stephane IR - Lehericy S FIR - Chupin, Marie IR - Chupin M FIR - Mangin, Jean-Francois IR - Mangin JF FIR - Bouhayia, Ali IR - Bouhayia A FIR - Allard, Michele IR - Allard M FIR - Ricolfi, Frederic IR - Ricolfi F FIR - Dubois, Dominique IR - Dubois D FIR - Bonceour Martel, Marie Paule IR - Bonceour Martel MP FIR - Cotton, Francois IR - Cotton F FIR - Bonafe, Alain IR - Bonafe A FIR - Chanalet, Stephane IR - Chanalet S FIR - Hugon, Francoise IR - Hugon F FIR - Bonneville, Fabrice IR - Bonneville F FIR - Cognard, Christophe IR - Cognard C FIR - Chollet, Francois IR - Chollet F FIR - Payoux, Pierre IR - Payoux P FIR - Voisin, Thierry IR - Voisin T FIR - Delrieu, Julien IR - Delrieu J FIR - Peiffer, Sophie IR - Peiffer S FIR - Hitzel, Anne IR - Hitzel A FIR - Allard, Michele IR - Allard M FIR - Zanca, Michel IR - Zanca M FIR - Monteil, Jacques IR - Monteil J FIR - Darcourt, Jacques IR - Darcourt J FIR - Perret, Bertrand IR - Perret B FIR - Vinel, Claire IR - Vinel C FIR - Caspar-Bauguil, Sylvie IR - Caspar-Bauguil S FIR - Olivier-Abbal, Pascale IR - Olivier-Abbal P FIR - Andrieu, Sandrine IR - Andrieu S FIR - Cantet, Christelle IR - Cantet C FIR - Coley, Nicola IR - Coley N EDAT- 2023/07/28 19:11 MHDA- 2023/07/31 06:42 CRDT- 2023/07/28 12:43 PHST- 2022/09/09 00:00 [received] PHST- 2023/04/07 00:00 [revised] PHST- 2023/07/31 06:42 [medline] PHST- 2023/07/28 19:11 [pubmed] PHST- 2023/07/28 12:43 [entrez] AID - 7232307 [pii] AID - 10.1093/ageing/afad133 [doi] PST - ppublish SO - Age Ageing. 2023 Jul 1;52(7):afad133. doi: 10.1093/ageing/afad133.