PMID- 37506151
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230731
IS  - 2050-4527 (Electronic)
IS  - 2050-4527 (Linking)
VI  - 11
IP  - 7
DP  - 2023 Jul
TI  - Expression of circulating angiotensin-converting enzyme 2 in children with asthma 
      and the effects of inhaled corticosteroids.
PG  - e922
LID - 10.1002/iid3.922 [doi]
LID - e922
AB  - BACKGROUND: The global spread of coronavirus disease 2019 (COVID-19) has resulted 
      in a significant disease burden, yet asthma patients do not have the expected 
      high morbidity and mortality rates in the pandemics of COVID-19. OBJECTIVE: To 
      find the difference of angiotensin-converting enzyme 2 (ACE2) in asthma and 
      nonasthma children and evaluate the effect of inhaled corticosteroids (ICS) on 
      its expression. METHODS: The ACE2, immunoglobulin E (IgE), and eosinophils were 
      tested in different children. RESULTS: A total of 157 children aged 3-16 years 
      were enrolled. The expression of ACE2 in asthma children were lower than 
      nonasthma children (T = -2.512, p = .013). Allergic nonasthma children had a 
      significant higher ACE2 expression than children with allergic asthma (p = .013) 
      and nonallergic asthma (p = .029). The expression of ACE2 had no significant 
      difference between first-diagnosed asthma children and that had been treated with 
      ICS for >/=6 months (F = 0.028, p = .598). The allergic asthma children showed a 
      significantly higher eosinophils cells (EC) count than the allergic nonasthma 
      (W = 200, p < .001) and nonallergic nonasthma children (W = 1089, p < .001). 
      Nonallergic asthma children also had a significant higher EC count than the 
      allergic non-asthma (W = 182.5, p < .001) and nonallergic non-asthma (W = 200.5, 
      p < .001) children. There was no significant difference in IgE levels between 
      asthmatic children and non-asthmatic children (W = 2792.5, p = .18). CONCLUSION: 
      Circulating ACE2 levels in asthmatic children were lower than those in 
      non-asthmatic children and ICS treatment for >/=6 months did not affect the 
      expression of ACE2 in peripheral blood in the asthma children.
CI  - (c) 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & 
      Sons Ltd.
FAU - Ma, Xiang
AU  - Ma X
AUID- ORCID: 0000-0001-6139-4355
AD  - Department of Respiratory Diseases, Children's Hospital affiliated to Shandong 
      University, Jinan, China.
AD  - Jinan Key Lab of Respiratory Diseases for Children, Jinan Children's Hospital, 
      Jinan, China.
FAU - Liu, Lesen
AU  - Liu L
AD  - Department of Infectious Diseases, Huaiyin People's Hospital, Jinan, China.
FAU - Sun, Jing
AU  - Sun J
AD  - Department of Respiratory Diseases, Children's Hospital affiliated to Shandong 
      University, Jinan, China.
AD  - Jinan Key Lab of Respiratory Diseases for Children, Jinan Children's Hospital, 
      Jinan, China.
FAU - Zhang, Yun
AU  - Zhang Y
AD  - Department of Respiratory Diseases, Children's Hospital affiliated to Shandong 
      University, Jinan, China.
AD  - Jinan Key Lab of Respiratory Diseases for Children, Jinan Children's Hospital, 
      Jinan, China.
FAU - Liu, Yanqin
AU  - Liu Y
AD  - Department of Respiratory Diseases, Children's Hospital affiliated to Shandong 
      University, Jinan, China.
AD  - Jinan Key Lab of Respiratory Diseases for Children, Jinan Children's Hospital, 
      Jinan, China.
FAU - Liu, Miao
AU  - Liu M
AD  - Department of Respiratory Diseases, Children's Hospital affiliated to Shandong 
      University, Jinan, China.
AD  - Jinan Key Lab of Respiratory Diseases for Children, Jinan Children's Hospital, 
      Jinan, China.
FAU - Wang, Bing
AU  - Wang B
AD  - Department of Respiratory Diseases, Children's Hospital affiliated to Shandong 
      University, Jinan, China.
AD  - Jinan Key Lab of Respiratory Diseases for Children, Jinan Children's Hospital, 
      Jinan, China.
FAU - Chang, Yuna
AU  - Chang Y
AD  - Department of Respiratory Diseases, Children's Hospital affiliated to Shandong 
      University, Jinan, China.
AD  - Jinan Key Lab of Respiratory Diseases for Children, Jinan Children's Hospital, 
      Jinan, China.
FAU - Han, Yuling
AU  - Han Y
AD  - Department of Respiratory Diseases, Children's Hospital affiliated to Shandong 
      University, Jinan, China.
FAU - Gai, Zhongtao
AU  - Gai Z
AD  - Jinan Key Lab of Respiratory Diseases for Children, Jinan Children's Hospital, 
      Jinan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immun Inflamm Dis
JT  - Immunity, inflammation and disease
JID - 101635460
RN  - EC 3.4.17.23 (Angiotensin-Converting Enzyme 2)
RN  - 0 (Adrenal Cortex Hormones)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Humans
MH  - Child
MH  - Angiotensin-Converting Enzyme 2
MH  - *COVID-19
MH  - *Asthma/drug therapy/metabolism
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Immunoglobulin E
PMC - PMC10373566
OTO - NOTNLM
OT  - COVID-19
OT  - angiotensin-converting enzyme 2
OT  - asthma
OT  - children
OT  - inhaled corticosteroids
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/28 19:11
MHDA- 2023/07/31 06:42
PMCR- 2023/07/27
CRDT- 2023/07/28 13:36
PHST- 2023/06/03 00:00 [revised]
PHST- 2023/02/10 00:00 [received]
PHST- 2023/06/07 00:00 [accepted]
PHST- 2023/07/31 06:42 [medline]
PHST- 2023/07/28 19:11 [pubmed]
PHST- 2023/07/28 13:36 [entrez]
PHST- 2023/07/27 00:00 [pmc-release]
AID - IID3922 [pii]
AID - 10.1002/iid3.922 [doi]
PST - ppublish
SO  - Immun Inflamm Dis. 2023 Jul;11(7):e922. doi: 10.1002/iid3.922.