PMID- 37507456
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230801
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Jul 28
TI  - Mid-lumbar (L3) epidural stimulation effects on bladder and external urethral 
      sphincter in non-injured and chronically transected urethane-anesthetized rats.
PG  - 12258
LID - 10.1038/s41598-023-39388-9 [doi]
LID - 12258
AB  - Recent pre-clinical and clinical spinal cord epidural stimulation (scES) 
      experiments specifically targeting the thoracolumbar and lumbosacral circuitries 
      mediating lower urinary tract (LUT) function have shown improvements in storage, 
      detrusor pressure, and emptying. With the existence of a lumbar spinal 
      coordinating center in rats that is involved with external urethral sphincter 
      (EUS) functionality during micturition, the mid-lumbar spinal cord (specifically 
      L3) was targeted in the current study with scES to determine if the EUS and thus 
      the void pattern could be modulated, using both intact and chronic complete 
      spinal cord injured female rats under urethane anesthesia. L3 scES at select 
      frequencies and intensities of stimulation produced a reduction in void volumes 
      and EUS burst duration in intact rats. After chronic transection, three different 
      subgroups of LUT dysfunction were identified and the response to L3 scES promoted 
      different cystometry outcomes, including changes in EUS bursting. The current 
      findings suggest that scES at the L3 level can generate functional 
      neuromodulation of both the urinary bladder and the EUS in intact and SCI rats to 
      enhance voiding in a variety of clinical scenarios.
CI  - (c) 2023. The Author(s).
FAU - Medina-Aguinaga, Daniel
AU  - Medina-Aguinaga D
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville 
      School of Medicine, 511 S. Floyd St., MDR, Room 111, Louisville, KY, 40202, USA.
FAU - Hoey, Robert F
AU  - Hoey RF
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville 
      School of Medicine, 511 S. Floyd St., MDR, Room 111, Louisville, KY, 40202, USA.
AD  - Physical Medicine and Rehabilitation Department, MetroHealth Rehabilitation 
      Institute of Ohio, Cleveland, OH, USA.
AD  - Physical Medicine and Rehabilitiation Department, Case Western Reserve University 
      School of Medicine, Cleveland, OH, USA.
FAU - Wilkins, Natasha L
AU  - Wilkins NL
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville 
      School of Medicine, 511 S. Floyd St., MDR, Room 111, Louisville, KY, 40202, USA.
FAU - Ugiliweneza, Beatrice
AU  - Ugiliweneza B
AD  - Department of Neurological Surgery, University of Louisville School of Medicine, 
      Louisville, KY, USA.
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA.
AD  - Department of Health Management and Systems Science, School of Public Health and 
      Information Science, University of Louisville, Louisville, KY, USA.
FAU - Fell, Jason
AU  - Fell J
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville 
      School of Medicine, 511 S. Floyd St., MDR, Room 111, Louisville, KY, 40202, USA.
FAU - Harkema, Susan J
AU  - Harkema SJ
AD  - Department of Neurological Surgery, University of Louisville School of Medicine, 
      Louisville, KY, USA.
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA.
FAU - Hubscher, Charles H
AU  - Hubscher CH
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville 
      School of Medicine, 511 S. Floyd St., MDR, Room 111, Louisville, KY, 40202, USA. 
      chhubs01@louisville.edu.
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA. chhubs01@louisville.edu.
LA  - eng
GR  - OT2 OD024898/OD/NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20230728
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 3IN71E75Z5 (Urethane)
RN  - 0 (Carbamates)
RN  - 0 (Carcinogens)
SB  - IM
MH  - Rats
MH  - Female
MH  - Animals
MH  - *Urinary Bladder
MH  - Urethra
MH  - Urethane/pharmacology
MH  - Rats, Sprague-Dawley
MH  - *Spinal Cord Injuries/therapy
MH  - Electromyography
MH  - Urination/physiology
MH  - Carbamates/pharmacology
MH  - Carcinogens/pharmacology
PMC - PMC10382500
COIS- The authors declare no competing interests.
EDAT- 2023/07/29 06:41
MHDA- 2023/07/31 06:43
PMCR- 2023/07/28
CRDT- 2023/07/28 23:21
PHST- 2023/05/10 00:00 [received]
PHST- 2023/07/25 00:00 [accepted]
PHST- 2023/07/31 06:43 [medline]
PHST- 2023/07/29 06:41 [pubmed]
PHST- 2023/07/28 23:21 [entrez]
PHST- 2023/07/28 00:00 [pmc-release]
AID - 10.1038/s41598-023-39388-9 [pii]
AID - 39388 [pii]
AID - 10.1038/s41598-023-39388-9 [doi]
PST - epublish
SO  - Sci Rep. 2023 Jul 28;13(1):12258. doi: 10.1038/s41598-023-39388-9.