PMID- 37508630
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230731
IS  - 2227-9067 (Print)
IS  - 2227-9067 (Electronic)
IS  - 2227-9067 (Linking)
VI  - 10
IP  - 7
DP  - 2023 Jun 29
TI  - Fetal Congenital Complete Heart Block: A Rare Case with an Extremely Low 
      Ventricular Rate and Review of Current Management Strategies.
LID - 10.3390/children10071132 [doi]
LID - 1132
AB  - Congenital complete heart block (CCHB) is associated with high intrauterine and 
      post-natal mortality. Prenatal detection and management, as well as appropriate 
      delivery planning, may improve the outcomes in CCHB. We describe a rare case of 
      CCHB that initially presented with fetal ascites and high-grade second-degree 
      heart block noted on fetal echocardiography. The mother was noted to be positive 
      for anti-SSA antibodies, and treatment with maternal steroids was started in an 
      effort to reverse the fetal cardiac conduction abnormality. However, the fetal 
      cardiac rhythm progressed to complete heart block by the follow up evaluation and 
      the fetus had a continual declination of heart rate throughout the pregnancy to a 
      low fetal heart rate of 25 beats per minute (bpm). This case demonstrates the 
      lowest fetal ventricular rate documented in the literature and illustrates a 
      severe presentation of a rare disease process. An overview of the existing 
      knowledge related to etiology, prenatal evaluation with fetal echocardiography 
      and fetal magnetocardiography, prenatal management, and delivery planning in 
      fetuses with prenatally detected CCHB is included.
FAU - Samples, Stefani
AU  - Samples S
AUID- ORCID: 0000-0002-2906-0651
AD  - Pediatric Cardiology, Ann & Robert Lurie Children's Hospital of Chicago, Chicago, 
      IL 60611, USA.
FAU - Fitt, Catherine
AU  - Fitt C
AD  - Pediatric Cardiology, Ann & Robert Lurie Children's Hospital of Chicago, Chicago, 
      IL 60611, USA.
FAU - Satzer, Michael
AU  - Satzer M
AD  - Pediatric Cardiology, Ann & Robert Lurie Children's Hospital of Chicago, Chicago, 
      IL 60611, USA.
FAU - Wakai, Ronald
AU  - Wakai R
AUID- ORCID: 0000-0002-9894-0484
AD  - Department of Medical Physics, University of Wisconsin, Madison, WI 53705, USA.
FAU - Strasburger, Janette
AU  - Strasburger J
AUID- ORCID: 0000-0002-6986-2544
AD  - Pediatric Cardiology, Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA.
FAU - Patel, Sheetal
AU  - Patel S
AUID- ORCID: 0000-0003-4257-1103
AD  - Pediatric Cardiology, Ann & Robert Lurie Children's Hospital of Chicago, Chicago, 
      IL 60611, USA.
LA  - eng
PT  - Case Reports
DEP - 20230629
PL  - Switzerland
TA  - Children (Basel)
JT  - Children (Basel, Switzerland)
JID - 101648936
PMC - PMC10378391
OTO - NOTNLM
OT  - autoimmune-mediated heart block
OT  - congenital complete heart block
OT  - fetal bradycardia
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/29 11:44
MHDA- 2023/07/29 11:45
PMCR- 2023/06/29
CRDT- 2023/07/29 01:07
PHST- 2023/05/15 00:00 [received]
PHST- 2023/06/22 00:00 [revised]
PHST- 2023/06/27 00:00 [accepted]
PHST- 2023/07/29 11:45 [medline]
PHST- 2023/07/29 11:44 [pubmed]
PHST- 2023/07/29 01:07 [entrez]
PHST- 2023/06/29 00:00 [pmc-release]
AID - children10071132 [pii]
AID - children-10-01132 [pii]
AID - 10.3390/children10071132 [doi]
PST - epublish
SO  - Children (Basel). 2023 Jun 29;10(7):1132. doi: 10.3390/children10071132.