PMID- 37508929
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230731
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 13
IP  - 7
DP  - 2023 Jun 27
TI  - Common and Distinct Functional Connectivity of the Orbitofrontal Cortex in 
      Depression and Schizophrenia.
LID - 10.3390/brainsci13070997 [doi]
LID - 997
AB  - Schizophrenia and depression are psychiatric disorders with overlapping clinical 
      and biological features. This study aimed to identify common and distinct 
      neuropathological mechanisms in schizophrenia and depression patients using 
      resting-state functional magnetic resonance imaging (fMRI). The study included 28 
      patients with depression (DEP), 29 patients with schizophrenia (SCH), and 30 
      healthy control subjects (HC). Intrinsic connectivity contrast (ICC) was used to 
      identify functional connectivity (FC) changes at the whole-brain level, and 
      significant ICC differences were found in the bilateral orbitofrontal cortex 
      (OFC) across all three groups. Further seed-based FC analysis indicated that 
      compared to the DEP and HC groups, the FC between bilateral OFC and medial 
      prefrontal cortex (MPFC), right anterior insula, and right middle frontal gyrus 
      were significantly lower in the SCH group. Additionally, the FC between right OFC 
      and left thalamus was decreased in both patient groups compared to the HC group. 
      Correlation analysis showed that the FC between OFC and MPFC was positively 
      correlated with cognitive function in the SCH group. These findings suggest that 
      OFC connectivity plays a critical role in the pathophysiology of schizophrenia 
      and depression and may provide new insights into the potential neural mechanisms 
      underlying these two disorders.
FAU - Huang, Huan
AU  - Huang H
AUID- ORCID: 0000-0003-2071-5954
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, 
      China.
FAU - Rong, Bei
AU  - Rong B
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, 
      China.
FAU - Chen, Cheng
AU  - Chen C
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, 
      China.
FAU - Wan, Qirong
AU  - Wan Q
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, 
      China.
FAU - Liu, Zhongchun
AU  - Liu Z
AUID- ORCID: 0000-0001-5410-0312
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, 
      China.
FAU - Zhou, Yuan
AU  - Zhou Y
AD  - Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
FAU - Wang, Gaohua
AU  - Wang G
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, 
      China.
AD  - Hubei Institute of Neurology and Psychiatry Research, Wuhan 430060, China.
FAU - Wang, Huiling
AU  - Wang H
AD  - Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, 
      China.
AD  - Department of Psychiatry, Zhongxiang Hospital of Renmin Hospital of Wuhan 
      University, Zhongxiang 431900, China.
AD  - Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 
      430071, China.
LA  - eng
GR  - 2042020kf0128/Fundamental Research Funds for the Central Universities/
GR  - WJ2021M142/Health Commission of Hubei Province scientific research project/
GR  - TFLC2018001/Medical Science Advancement Program of Wuhan University/
PT  - Journal Article
DEP - 20230627
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC10377532
OTO - NOTNLM
OT  - depression
OT  - functional connectivity
OT  - intrinsic connectivity contrast
OT  - resting-state functional magnetic resonance imaging
OT  - schizophrenia
COIS- All authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as potential 
      conflicts of interest.
EDAT- 2023/07/29 11:43
MHDA- 2023/07/29 11:44
PMCR- 2023/06/27
CRDT- 2023/07/29 01:09
PHST- 2023/04/27 00:00 [received]
PHST- 2023/06/12 00:00 [revised]
PHST- 2023/06/22 00:00 [accepted]
PHST- 2023/07/29 11:44 [medline]
PHST- 2023/07/29 11:43 [pubmed]
PHST- 2023/07/29 01:09 [entrez]
PHST- 2023/06/27 00:00 [pmc-release]
AID - brainsci13070997 [pii]
AID - brainsci-13-00997 [pii]
AID - 10.3390/brainsci13070997 [doi]
PST - epublish
SO  - Brain Sci. 2023 Jun 27;13(7):997. doi: 10.3390/brainsci13070997.