PMID- 37509142
OWN - NLM
STAT- MEDLINE
DCOM- 20230731
LR  - 20230801
IS  - 2218-273X (Electronic)
IS  - 2218-273X (Linking)
VI  - 13
IP  - 7
DP  - 2023 Jul 12
TI  - An Integrated Glycosylation Signature of Rheumatoid Arthritis.
LID - 10.3390/biom13071106 [doi]
LID - 1106
AB  - Rheumatoid arthritis (RA) Is a highly prevalent autoimmune disease that affects 
      the joints but also various other organs. The disease is characterized by 
      autoantibodies that are often already observed pre-disease. Since the 1980s, it 
      has been known that antibody glycosylation is different in RA as compared to 
      control individuals. While the literature on glycosylation changes in RA is 
      dominated by reports on serum or plasma immunoglobulin G (IgG), our recent 
      studies have indicated that the glycosylation changes observed for immunoglobulin 
      A (IgA) and total serum N-glycome (TSNG) may be similarly prominent, and useful 
      in differentiating between the RA patients and controls, or as a proxy of the 
      disease activity. In this study, we integrated and compared the RA glycosylation 
      signatures of IgG, IgA and TSNG, all determined in the pregnancy-induced 
      amelioration of rheumatoid arthritis (PARA) cohort. We assessed the association 
      of the altered glycosylation patterns with the disease, autoantibody positivity 
      and disease activity. Our analyses indicated a common, composite glycosylation 
      signature of RA that was independent of the autoantibody status.
FAU - Mayboroda, Oleg A
AU  - Mayboroda OA
AUID- ORCID: 0000-0001-8739-9875
AD  - Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA 
      Leiden, The Netherlands.
FAU - Lageveen-Kammeijer, Guinevere S M
AU  - Lageveen-Kammeijer GSM
AUID- ORCID: 0000-0001-7670-1151
AD  - Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA 
      Leiden, The Netherlands.
AD  - Analytical Biochemistry, University of Groningen, 9700 RB Groningen, The 
      Netherlands.
FAU - Wuhrer, Manfred
AU  - Wuhrer M
AUID- ORCID: 0000-0002-0814-4995
AD  - Center for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA 
      Leiden, The Netherlands.
FAU - Dolhain, Radboud J E M
AU  - Dolhain RJEM
AD  - Department of Rheumatology, Erasmus Medical Center, 3015 CN Rotterdam, The 
      Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230712
PL  - Switzerland
TA  - Biomolecules
JT  - Biomolecules
JID - 101596414
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin A)
SB  - IM
MH  - Female
MH  - Pregnancy
MH  - Humans
MH  - Glycosylation
MH  - *Arthritis, Rheumatoid
MH  - Autoantibodies
MH  - Immunoglobulin G
MH  - Immunoglobulin A
PMC - PMC10377307
OTO - NOTNLM
OT  - antibody
OT  - glycosylation
OT  - rheumatoid arthritis
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/29 11:54
MHDA- 2023/07/31 11:42
PMCR- 2023/07/12
CRDT- 2023/07/29 01:10
PHST- 2023/05/24 00:00 [received]
PHST- 2023/06/27 00:00 [revised]
PHST- 2023/06/29 00:00 [accepted]
PHST- 2023/07/31 11:42 [medline]
PHST- 2023/07/29 11:54 [pubmed]
PHST- 2023/07/29 01:10 [entrez]
PHST- 2023/07/12 00:00 [pmc-release]
AID - biom13071106 [pii]
AID - biomolecules-13-01106 [pii]
AID - 10.3390/biom13071106 [doi]
PST - epublish
SO  - Biomolecules. 2023 Jul 12;13(7):1106. doi: 10.3390/biom13071106.