PMID- 37509545
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230731
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 11
IP  - 7
DP  - 2023 Jul 5
TI  - Validating Prediction Tools for Autoimmune Encephalitis in Adult Taiwanese 
      Patients: A Retrospective Study.
LID - 10.3390/biomedicines11071906 [doi]
LID - 1906
AB  - Autoimmune encephalitis (AE) is a neurological emergency. We aimed to analyze the 
      application and effectiveness of the currently available prediction tools for AE 
      patients in Taiwan. We retrospectively collected 27 AE patients between January 
      2008 and December 2019. Antibody Prevalence in Epilepsy (APE) score, Response to 
      Immunotherapy in Epilepsy (RITE) score, and anti-NMDAR Encephalitis One Year 
      Functional Status (NEOS) score were applied to validate their usability. Based on 
      the defined cutoff values, the sensitivity and specificity of each score were 
      calculated. A receiver operating characteristic (ROC) curve and the area under 
      the curve (AUC) were generated for each scoring system. The AUC value of APE was 
      0.571. The AUC value of RITE was 0.550. The AUC values for the NEOS score at 
      discharge and long-term follow-up were 0.645 and 0.796, respectively. The 
      performance of APE and RITE scores was suboptimal in the Taiwanese cohort, 
      probably due to the limitations of the small sample size and single ethnicity. On 
      the other hand, the NEOS score performed better on long-term follow-up than at 
      discharge.
FAU - Lu, Yan-Ting
AU  - Lu YT
AUID- ORCID: 0000-0002-4075-6983
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, College of 
      Medicine, Chang Gung University, Kaohsiung 833401, Taiwan.
FAU - Lin, Chih-Hsiang
AU  - Lin CH
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, College of 
      Medicine, Chang Gung University, Kaohsiung 833401, Taiwan.
FAU - Ho, Chen-Jui
AU  - Ho CJ
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, College of 
      Medicine, Chang Gung University, Kaohsiung 833401, Taiwan.
FAU - Chen, Shih-Ying
AU  - Chen SY
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, College of 
      Medicine, Chang Gung University, Kaohsiung 833401, Taiwan.
FAU - Tsai, Meng-Han
AU  - Tsai MH
AUID- ORCID: 0000-0002-4570-5712
AD  - Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, College of 
      Medicine, Chang Gung University, Kaohsiung 833401, Taiwan.
AD  - College of Medicine, Medical School, Chang Gung University, Taoyuan 333323, 
      Taiwan.
AD  - Genomics and Proteomics Core Laboratory, Department of Medical Research, 
      Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833401, Taiwan.
LA  - eng
GR  - EX111-11022NI/National Health Research Institutes/
GR  - 110-2314-B-182A-076-MY3/Ministry of Science and Technology/
GR  - CMRPG8L1331/Chang Gung Medical Foundation/
GR  - CMRPG8M1091/Chang Gung Medical Foundation/
PT  - Journal Article
DEP - 20230705
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC10377279
OTO - NOTNLM
OT  - anti-N-methyl-D-aspartate receptor encephalitis
OT  - anti-NMDAR encephalitis one-year functional status score
OT  - antibody prevalence in epilepsy score
OT  - autoimmune diseases of the nervous system
OT  - autoimmune encephalitis
OT  - response to immunotherapy in epilepsy score
OT  - validation
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/29 11:45
MHDA- 2023/07/29 11:46
PMCR- 2023/07/05
CRDT- 2023/07/29 01:12
PHST- 2023/05/05 00:00 [received]
PHST- 2023/06/28 00:00 [revised]
PHST- 2023/06/29 00:00 [accepted]
PHST- 2023/07/29 11:46 [medline]
PHST- 2023/07/29 11:45 [pubmed]
PHST- 2023/07/29 01:12 [entrez]
PHST- 2023/07/05 00:00 [pmc-release]
AID - biomedicines11071906 [pii]
AID - biomedicines-11-01906 [pii]
AID - 10.3390/biomedicines11071906 [doi]
PST - epublish
SO  - Biomedicines. 2023 Jul 5;11(7):1906. doi: 10.3390/biomedicines11071906.