PMID- 37510125
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230731
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 13
IP  - 14
DP  - 2023 Jul 15
TI  - Paediatric Spitzoid Neoplasms: 10-Year Retrospective Study Characterizing 
      Histological, Clinical, Dermoscopic Presentation and FISH Test Results.
LID - 10.3390/diagnostics13142380 [doi]
LID - 2380
AB  - INTRODUCTION: Spitzoid lesions are a wide tumour class comprising Spitz nevus 
      (SN), atypical Spitz tumour (AST) and Spitz melanoma (SM). MATERIALS AND METHODS: 
      We conducted a single-centre-based retrospective survey on all histologically 
      diagnosed spitzoid lesions of paediatric patients (1-18 years) of the last 10 
      years (2012-2022). Histopathological reports and electronic records of patients 
      were used to retrieve relevant data regarding patients' features, clinical and 
      dermatoscopical aspects of lesions when recorded, and FISH tests when present. 
      RESULTS: Of 255 lesions, 82% were histologically benign, 17% atypical, 1% 
      malignant. Clinically, 100% of SM were large (>/=6 mm) and raised; AST were mainly 
      large (63%), raised (98%), pink (95%). Small (</=5 mm), pigmented, flat lesions 
      correlated with benign histology (respectively 90%, 97%, 98% SN) (p < 0.0001). 
      Dermatoscopical patterns were analysed in 100 patients: starburst pattern 
      correlated with benign histology (26% SN (p = 0.004)), while multicomponent 
      pattern correlated with atypical/malignant lesions (56% AST, 50% SM (p = 
      0.0052)). Eighty-five lesions were subjected to fluorescence in situ 
      hybridization (FISH): 34 (71% AST; 29% SN) were FISH-positive; 51 (63% SN; 37% 
      AST) were FISH-negative (p = 0.0038). DISCUSSION: This study confirmed 
      predominant benign histology (82%) of paediatric spitzoid lesions, thus detecting 
      17% AST and 1% SM, highlighting the need for caution in handling spitzoid 
      lesions. CONCLUSION: Until AST are considered potentially malignant 
      proliferations and no reliable criteria are identified to distinguish them, the 
      authors suggest a prudent approach, especially in children.
FAU - Herzum, Astrid
AU  - Herzum A
AUID- ORCID: 0000-0001-6373-8801
AD  - Dermatology Unit, U.O.C. Dermatologia e Centro Angiomi, IRCCS Istituto Giannina 
      Gaslini, Via Gerolamo Gaslini, 5-16147 Genova, Italy.
FAU - Occella, Corrado
AU  - Occella C
AD  - Dermatology Unit, U.O.C. Dermatologia e Centro Angiomi, IRCCS Istituto Giannina 
      Gaslini, Via Gerolamo Gaslini, 5-16147 Genova, Italy.
FAU - Vellone, Valerio Gaetano
AU  - Vellone VG
AUID- ORCID: 0000-0002-5107-1584
AD  - Pathology Unit, U.O.C. Anatomia Patologica, IRCCS Istituto Giannina Gaslini, Via 
      Gerolamo Gaslini, 5-16147 Genova, Italy.
FAU - Gariazzo, Lodovica
AU  - Gariazzo L
AD  - Dermatology Unit, U.O.C. Dermatologia e Centro Angiomi, IRCCS Istituto Giannina 
      Gaslini, Via Gerolamo Gaslini, 5-16147 Genova, Italy.
FAU - Pastorino, Carlotta
AU  - Pastorino C
AD  - Dermatology Unit, U.O.C. Dermatologia e Centro Angiomi, IRCCS Istituto Giannina 
      Gaslini, Via Gerolamo Gaslini, 5-16147 Genova, Italy.
FAU - Ferro, Jacopo
AU  - Ferro J
AUID- ORCID: 0000-0002-1670-178X
AD  - Dermatology Unit, U.O.C. Dermatologia e Centro Angiomi, IRCCS Istituto Giannina 
      Gaslini, Via Gerolamo Gaslini, 5-16147 Genova, Italy.
FAU - Sementa, Angela
AU  - Sementa A
AD  - Pathology Unit, U.O.C. Anatomia Patologica, IRCCS Istituto Giannina Gaslini, Via 
      Gerolamo Gaslini, 5-16147 Genova, Italy.
FAU - Mazzocco, Katia
AU  - Mazzocco K
AUID- ORCID: 0000-0002-6599-5681
AD  - Pathology Unit, U.O.C. Anatomia Patologica, IRCCS Istituto Giannina Gaslini, Via 
      Gerolamo Gaslini, 5-16147 Genova, Italy.
FAU - Vercellino, Nadia
AU  - Vercellino N
AD  - Dermatology Unit, U.O.C. Dermatologia e Centro Angiomi, IRCCS Istituto Giannina 
      Gaslini, Via Gerolamo Gaslini, 5-16147 Genova, Italy.
FAU - Viglizzo, Gianmaria
AU  - Viglizzo G
AD  - Dermatology Unit, U.O.C. Dermatologia e Centro Angiomi, IRCCS Istituto Giannina 
      Gaslini, Via Gerolamo Gaslini, 5-16147 Genova, Italy.
LA  - eng
PT  - Journal Article
DEP - 20230715
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC10378405
OTO - NOTNLM
OT  - FISH
OT  - multicomponent pattern
OT  - paediatric
OT  - spitz dermoscopy
OT  - spitz nevus
COIS- The authors declare no conflict of interest.
EDAT- 2023/07/29 11:52
MHDA- 2023/07/29 11:53
PMCR- 2023/07/15
CRDT- 2023/07/29 01:16
PHST- 2023/06/12 00:00 [received]
PHST- 2023/07/13 00:00 [revised]
PHST- 2023/07/13 00:00 [accepted]
PHST- 2023/07/29 11:53 [medline]
PHST- 2023/07/29 11:52 [pubmed]
PHST- 2023/07/29 01:16 [entrez]
PHST- 2023/07/15 00:00 [pmc-release]
AID - diagnostics13142380 [pii]
AID - diagnostics-13-02380 [pii]
AID - 10.3390/diagnostics13142380 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2023 Jul 15;13(14):2380. doi: 10.3390/diagnostics13142380.